Volume 13, Issue 4 (5-2015)                   IJRM 2015, 13(4): 195-202 | Back to browse issues page

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Borges Cavalcante M, Silva Costa F D, Barini R, Araujo Júnior E. Granulocyte colony-stimulating factor and reproductive medicine: A review. IJRM. 2015; 13 (4) :195-202
URL: http://ijrm.ssu.ac.ir/article-1-640-en.html
1- Department of Gynecology and Obstetrics, University of Fortaleza, Fortaleza-CE, Brazil
2- Department of Perinatal Medicine, Pregnancy Research Centre, University of Melbourne, The Royal Women’s Hospital, Melbourne, Victoria, Australia
3- Department of Obstetrics and Gynecology, State University of Campinas, Campinas-SP, Brazil
4- Department of Obstetrics, Paulista School of Medicine, São Paulo Federal University, São Paulo-SP, Brazil , araujojred@terra.com.br
Abstract:   (2019 Views)
Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine.
Objective: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed.
Materials and Methods: Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium.
Results: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases. Of the remaining 177 publications, seven studies were included in the present review.
Conclusion: Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established.
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Type of Study: Original Article |

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