International Journal of
Reproductive Biomedicine
Sat, Apr 27, 2024
[Archive]
Volume 13, Issue 9 (10-2015)
IJRM 2015, 13(9): 571-576 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Irani S, Ahmadi F, Javam M, VosoughTaghi dizaj A, Niknejad F. Outcome of isolated fetal choroid plexus cyst detected in prenatal sonography among infertile patients referred to Royan Institute: A 3-year study. IJRM 2015; 13 (9) :571-576
URL: http://ijrm.ir/article-1-678-en.html
URL: http://ijrm.ir/article-1-678-en.html
1- Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
2- Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , dr.ahmadi1390@gmail.com
2- Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , dr.ahmadi1390@gmail.com
Abstract: (6822 Views)
Background: Several studies have assessed the correlation of fetal choroid plexus cyst (CPC) and the risk of congenital anomalies, but few ones have discussed isolated CPC (with no other abnormal sonographic finding).
Objective: The aim of this study was to determine the outcome of isolated fetal choroid plexus cyst and to specify its clinical significance.
Materials and Methods: This cross sectional study was carried out at Royan Institute in Tehran, Iran, between April 2009 and December 2012. All prenatal sonographies in this period of time were assessed using a computerized database and fetuses who had isolated CPC were recruited in the study. Sonography reports, mother serum screening test results, fetal echocardiography and amniocentesis were evaluated until birth. A follow-up phone call was made to all individuals to learn about the neonatal outcomes.
Results: Overall, 6240 prenatal sonographies were performed in this setting during this period. Isolated CPC was detected in 64 fetuses. The results of double test (N=30), triple test (N=5) and fetal echocardiography (N =24) were normal. Quadruple test result showed 3 abnormal out of 29 cases that all had normal karyotypes. Four samples were dropped out due to premature rupture of membranes (N=3) and intrauterine fetal death (N=1). It was found that the outcomes of all remaining fetuses (N=60) were normal and no anomaly ones were seen until birth.
Conclusion: Isolated CPC is a benign regressive condition with no clinical significance.
Objective: The aim of this study was to determine the outcome of isolated fetal choroid plexus cyst and to specify its clinical significance.
Materials and Methods: This cross sectional study was carried out at Royan Institute in Tehran, Iran, between April 2009 and December 2012. All prenatal sonographies in this period of time were assessed using a computerized database and fetuses who had isolated CPC were recruited in the study. Sonography reports, mother serum screening test results, fetal echocardiography and amniocentesis were evaluated until birth. A follow-up phone call was made to all individuals to learn about the neonatal outcomes.
Results: Overall, 6240 prenatal sonographies were performed in this setting during this period. Isolated CPC was detected in 64 fetuses. The results of double test (N=30), triple test (N=5) and fetal echocardiography (N =24) were normal. Quadruple test result showed 3 abnormal out of 29 cases that all had normal karyotypes. Four samples were dropped out due to premature rupture of membranes (N=3) and intrauterine fetal death (N=1). It was found that the outcomes of all remaining fetuses (N=60) were normal and no anomaly ones were seen until birth.
Conclusion: Isolated CPC is a benign regressive condition with no clinical significance.
Type of Study: Original Article |
References
1. Cheng PJ, Shaw SW, Soong YK. Association of fetal choroid plexus cysts with trisomy 18 in a population previously screened by nuchal translucency thickness measurement. J Soc Gynecol Investig 2006; 13: 280-284. [DOI:10.1016/j.jsgi.2006.02.013]
2. Coco C, Jeanty P. Karyotyping of fetuses with isolated choroid plexus cysts is not justified in an unselected population. J Ultrasound Med 2004; 23: 899-906. [DOI:10.7863/jum.2004.23.7.899]
3. DiPietro J, Costigan K, Cristofalo E, Lu Y, Bird CW, McShane CA, et al. Choroid plexus cysts do not affect fetal neurodevelopment. J Perinatol 2006; 26: 622-627. [DOI:10.1038/sj.jp.7211574]
4. Landy HJ, Bannon P, Zalud I, Collea JV, Lewis KM, Bartholomew ML, et al. Association of sex of the fetus in isolated fetal choroid plexus cysts. J Ultrasound Med 1999; 18: 769-771. [DOI:10.7863/jum.1999.18.11.769]
5. Gupta J, Farrell T, Hau C, Farrell TA, Irving HC, Mason G, et al. Clinical significance of fetal choroid plexus cysts. Lancet 1995; 346: 724-729. [DOI:10.1016/S0140-6736(95)91502-8]
6. Epelman M, Daneman A, Blaser SI, Ortiz-Neira C, Konen O, Jarrín J, et al. Differential Diagnosis of Intracranial Cystic Lesions at Head US: Correlation with CT and MR Imaging1. Radiographics 2006; 26: 173-196. [DOI:10.1148/rg.261055033]
7. DiPietro JA, Cristofalo EA, Voegtline KM, Crino J. Isolated prenatal choroid plexus cysts do not affect child development. Prenatal Diag 2011; 31: 745-749. [DOI:10.1002/pd.2757]
8. Cristofalo E, Dipietro J, Costigan K, Nelson P, Crino J. Women's response to fetal choroid plexus cysts detected by prenatal ultrasound. J Perinatol 2006; 26: 215-223. [DOI:10.1038/sj.jp.7211489]
9. Lopez JA, Reich D. Choroid plexus cysts. J Am Board Fam Med 2006; 19: 422-425. [DOI:10.3122/jabfm.19.4.422]
10. DeRoo T, Harris R, Sargent S, Denholm TA, Crow HC. Fetal choroid plexus cysts: prevalence, clinical significance, and sonographic appearance. Am J Roentgenol 1988; 151: 1179-1181. [DOI:10.2214/ajr.151.6.1179]
11. Chitkara U, Cogswell C, Norton K, Wilkins IA, Mehalek K, Berkowitz RL. Choroid plexus cysts in the fetus: a benign anatomic variant or pathologic entity? Report of 41 cases and review of the literature. Obstet Gynecol 1988; 72: 185-189.
12. Bronsteen R, Lee W, Vettraino IM, Huang R, Comstock CH. Second-trimester sonography and trisomy 18 the significance of isolated choroid plexus cysts after an examination that includes the fetal hands. J Ultrasound Med 2004; 23: 241-245. [DOI:10.7863/jum.2004.23.2.241]
13. Chudleigh P, Pearce JM, Campbell S. The prenatal diagnosis of transient cysts of the fetal choroid plexus. Prenatal Diag 1984; 4: 135-137. [DOI:10.1002/pd.1970040207]
14. Nyberg DA, Kramer D, Resta R, Kapur R, Mahony BS, Luthy DA. Prenatal sonographic findings of trisomy 18: review of 47 cases. J Ultrasound Med 1993; 12: 103-113. [DOI:10.7863/jum.1993.12.2.103]
15. Ostlere S, Irving H, Lilford R. Fetal choroid plexus cysts: a report of 100 cases. Radiology 1990; 175: 753-755. [DOI:10.1148/radiology.175.3.2188298]
16. Sullivan A, Giudice T, Vavelidis F, Thiagarajah S. Choroid plexus cysts: Is biochemical testing a valuable adjunct to targeted ultrasonography? Am J Obestet Gynecol 1999; 181: 260-265. [DOI:10.1016/S0002-9378(99)70545-4]
17. Demasio K, Canterino J, Ananth C, Fernandez C, Smulian J, Vintzileos A. Isolated choroid plexus cyst in low-risk women less than 35 years old. Am J Obestet Gynecol 2002; 187: 1246-1249. [DOI:10.1067/mob.2002.127463]
18. Kupferminc MJ, Tamura RK, Sabbagha RE, Sabbagha RE, Parilla BV, Cohen LS, et al. Isolated choroid plexus cyst (s): an indication for amniocentesis. Am J Obestet Gynecol 1994; 171: 1068-1071. [DOI:10.1016/0002-9378(94)90037-X]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
