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Reproductive Biomedicine
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Volume 15, Issue 6 (7-2017)
IJRM 2017, 15(6): 345-350 |
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Rahsepar M, Mahjoub S, Esmaeilzadeh S, Kanafchian M, Ghasemi M. Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome. IJRM 2017; 15 (6) :345-350
URL: http://ijrm.ir/article-1-832-en.html
URL: http://ijrm.ir/article-1-832-en.html
Maryam Rahsepar1 
, Soleiman Mahjoub * 2, Sedigheh Esmaeilzadeh3 , Maryam Kanafchian1 , Maryam Ghasemi3
, Soleiman Mahjoub * 2, Sedigheh Esmaeilzadeh3 , Maryam Kanafchian1 , Maryam Ghasemi3
1- Student Research Committee, Babol University of Medical Sciences, Babol, Iran
2- Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran , smahjoub20@gmail.com
3- Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
2- Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran , smahjoub20@gmail.com
3- Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Abstract: (3207 Views)
Background: There is little evidence about antioxidant properties of vitamin D. Recent studies suggest that oxidative stress may play a major role in the pathophysiology of polycystic ovary syndrome (PCOS), but the association of vitamin D with oxidative stress is still not known in PCOS.
Objective: The goal of the present study was to evaluate the correlation between serum 25-hydroxy vitamin D and oxidative stress markers in PCOS group compared to control group.
Materials and Methods: 60 PCOS women (20-40 yr old) and 90 healthy women as control group were participated in this case-control study. Fasting serum level of 25-hydroxy vitamin D 25(OH) D, glucose, insulin, calcium, malondialdehyde (MDA), protein carbonyl (PC), also homeostasis model assessment for insulin resistance (HOMA-IR) and fasting glucose to insulin ratio (FGIR) were measured.
Results: It was found that the mean of serum 25(OH)D was lower in the PCOS group (10.76±4.17) than in the control group (12.07±6.26) but this difference was not statistically significant (p=0.125). Fasting insulin, HOMA-IR and MDA were significantly higher in the PCOS patients as compared to the controls, whereas PC level did not differ for the two groups (p=0.156). No significant correlations were found between 25(OH) D levels and oxidative stress markers (MDA and PC).
Conclusion: The findings indicated no significant differences in the serum 25(OH) D levels between the PCOS patients and the matched controls. Also, no correlation was found between the serum vitamin D levels and oxidative stress markers in both groups.
Objective: The goal of the present study was to evaluate the correlation between serum 25-hydroxy vitamin D and oxidative stress markers in PCOS group compared to control group.
Materials and Methods: 60 PCOS women (20-40 yr old) and 90 healthy women as control group were participated in this case-control study. Fasting serum level of 25-hydroxy vitamin D 25(OH) D, glucose, insulin, calcium, malondialdehyde (MDA), protein carbonyl (PC), also homeostasis model assessment for insulin resistance (HOMA-IR) and fasting glucose to insulin ratio (FGIR) were measured.
Results: It was found that the mean of serum 25(OH)D was lower in the PCOS group (10.76±4.17) than in the control group (12.07±6.26) but this difference was not statistically significant (p=0.125). Fasting insulin, HOMA-IR and MDA were significantly higher in the PCOS patients as compared to the controls, whereas PC level did not differ for the two groups (p=0.156). No significant correlations were found between 25(OH) D levels and oxidative stress markers (MDA and PC).
Conclusion: The findings indicated no significant differences in the serum 25(OH) D levels between the PCOS patients and the matched controls. Also, no correlation was found between the serum vitamin D levels and oxidative stress markers in both groups.
Type of Study: Original Article |
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