Volume 16, Issue 3 (March 2018)                   IJRM 2018, 16(3): 131-148 | Back to browse issues page

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Moghbelinejad S, Mozdarani H, Ghoraeian P, Asadi R. Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review. IJRM 2018; 16 (3) :131-148
URL: http://ijrm.ir/article-1-1023-en.html
Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review
Sahar Moghbelinejad1 , Hossein Mozdarani * 2, Pegah Ghoraeian3 , Reihaneh Asadi4
1- Department of Genetics, School of Sciences, Qazvin University of Medical Sciences, Qazvin, Iran
2- Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , Mozdarah@modares.ac.ir
3- Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
4- Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (4242 Views)
The male factor contributes to 50% of infertility. The cause of male infertility is idiopathic and could be congenital or acquired. Among different factors which are involved in idiopathic male infertility, genetic factors are the most prevalent causes of the disease. Considering, the high prevalence of male infertility in Iran and the importance of genetic factors in the accession of it, in this article we reviewed the various studies which have been published during the last 17 yr on the genetic basis of male infertility in Iran. To do this, the PubMed and Scientific information database (SID) were regarded for the most relevant papers published in the last 17 yr referring to the genetics of male factor infertility using the keywords „„genetics‟‟, “cytogenetic”, „„male infertility”, and “Iranian population”. Literatures showed that among the Iranian infertile men Yq microdeletion and chromosomal aberrations are two main factors that intervene in the genetics of male infertility. Also, protamine deficiency (especially P2) is shown to have an influence on fertilization rate and pregnancy outcomes. The highest rate of sperm DNA damages has been found among the asthenospermia patients. In several papers, the relation between other important factors such as single gene mutations and polymorphisms with male infertility has also been reported. Recognition of the genetic factors that influence the fertility of Iranian men will shed light on the creation of guidelines for the diagnosis, consultation, and treatment of the patients."
Keywords: Iran, Male infertility, Genetics, Cytogenetic, Peripheral blood, Sperm
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Type of Study: Review Article |
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