International Journal of
Reproductive Biomedicine
Thu, Dec 26, 2024
[Archive]
Volume 18, Issue 2 (February 2020)
IJRM 2020, 18(2): 129-134 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Martínez-Leal B, Ivette Álvarez-Banderas K, Sánchez-Dávila H, Dávila-Rodríguez I, Cortés-Gutiérrez E I. Human papillomavirus as a single infection in pregnant women from Northeastern Mexico: Cross-sectional study. IJRM 2020; 18 (2) :129-134
URL: http://ijrm.ir/article-1-1040-en.html
URL: http://ijrm.ir/article-1-1040-en.html
Bernardo Martínez-Leal1 
, Karla Ivette Álvarez-Banderas2 , Homero Sánchez-Dávila2 , Imelda Dávila-Rodríguez3 , Elva Irene Cortés-Gutiérrez * 4
, Karla Ivette Álvarez-Banderas2 , Homero Sánchez-Dávila2 , Imelda Dávila-Rodríguez3 , Elva Irene Cortés-Gutiérrez * 4
1- Universidad de Monterrey, Vicerrectoría Ciencias de la Salud, San Pedro Garza García, México.
2- Department of Clinical Dysplasia, Gynecology and Obstetrics No.23 Hospital, Mexican Institute of Social Security, Monterrey, Mexico.
3- Universidad Autónoma de Nuevo León, Faculty of Public Health and Nutrition, Monterrey, México.
4- Universidad Autónoma de Nuevo León, Faculty of Biological Sciences, San Nicolás de los Garza, México. ,elvairenecortes@yahoo.com.mx
2- Department of Clinical Dysplasia, Gynecology and Obstetrics No.23 Hospital, Mexican Institute of Social Security, Monterrey, Mexico.
3- Universidad Autónoma de Nuevo León, Faculty of Public Health and Nutrition, Monterrey, México.
4- Universidad Autónoma de Nuevo León, Faculty of Biological Sciences, San Nicolás de los Garza, México. ,
Abstract: (2446 Views)
Background: The role of human papillomavirus (HPV) as single or multiple infections in pregnant women would be relevant to determine the time to progression and/or the time to regression of cervical lesions.
Objective: In this preliminary study, we determined the prevalence of HPV as single or multiple infections in pregnant women from Northeastern Mexico.
Materials and Methods: Samples from 31 pregnant and 62 nonpregnant women were examined between January 2015 and November 2015 at UMAE-23 of the Instituto Mexicano del Seguro Social (IMSS). The samples of cervicovaginal exudate were obtained for HPV DNA detection using the INNO-LiPA test, and HPV infections were analyzed as single or multiple infections. Participants completed a questionnaire on sociodemographic, gynecological, obstetric, and sexual behavior characteristics.
Results: The mean age of the pregnant women was 25.7 ± 4.8 yr, with an average time of pregnancy of 6 ± 1 months at the time of the study. With respect to age, parity, smoking history, or oral contraceptive use no statistically significant differences between the two studied groups was observed. The HPV infection was 2.7 times higher in pregnant women (35%) than in the control group (13%). In total, 78% of the pregnant women who were HPV-positive presented with single infections compared with 28% of the nonpregnant women.
Conclusion: A higher prevalence of HPV as a single infection was found in this sample of pregnant Mexican women. Follow-up is necessary to evaluate the persistence or regression of the infection.
Objective: In this preliminary study, we determined the prevalence of HPV as single or multiple infections in pregnant women from Northeastern Mexico.
Materials and Methods: Samples from 31 pregnant and 62 nonpregnant women were examined between January 2015 and November 2015 at UMAE-23 of the Instituto Mexicano del Seguro Social (IMSS). The samples of cervicovaginal exudate were obtained for HPV DNA detection using the INNO-LiPA test, and HPV infections were analyzed as single or multiple infections. Participants completed a questionnaire on sociodemographic, gynecological, obstetric, and sexual behavior characteristics.
Results: The mean age of the pregnant women was 25.7 ± 4.8 yr, with an average time of pregnancy of 6 ± 1 months at the time of the study. With respect to age, parity, smoking history, or oral contraceptive use no statistically significant differences between the two studied groups was observed. The HPV infection was 2.7 times higher in pregnant women (35%) than in the control group (13%). In total, 78% of the pregnant women who were HPV-positive presented with single infections compared with 28% of the nonpregnant women.
Conclusion: A higher prevalence of HPV as a single infection was found in this sample of pregnant Mexican women. Follow-up is necessary to evaluate the persistence or regression of the infection.
Type of Study: Original Article |
Subject:
Pregnancy Health
References
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90. [DOI:10.3322/caac.20107] [PMID]
2. Aguilar- Lemarroy A, Vallejo-Ruiz, Cortés Gutiérrez EI, Salgado-Bernabé ME, Ramos-González NP, Ortega-Cervantes, L, et al. Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: type-specific prevalence and HPV coinfections. J Med Virol 2015; 87: 871-884. [DOI:10.1002/jmv.24099] [PMID]
3. Schlecht NF, Kulaga S, Robitaille J, Ferraira S, Santos M, Miyamura RA, et al. Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA 2001; 286: 3106-3114. [DOI:10.1001/jama.286.24.3106] [PMID]
4. Clifford GM, Smith JS, Aguado T, Franceshi S. Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. Br J Cancer 2003; 89: 101-105. [DOI:10.1038/sj.bjc.6601024] [PMID] [PMCID]
5. Snijders PJ, Steenbergen RD, Heideman DA, Meijer CJ. HPV-mediated cervical carciogenesis: concepts and clinical implications. J Pathol 2005; 208: 152-164. [DOI:10.1002/path.1866] [PMID]
6. Torres-Mejia G, Ortega-Olvera C, Angeles-Llerenas A, Villalobos-Hernández AL, Salmerón-Castro J, Lazcano-Ponce E, et al. Utilization patterns of prevention and early diagnosis for cancer in women. Salud Publica Mex 2013; 55 (Suppl.): S241-S248. [DOI:10.21149/spm.v55s2.5121]
7. Sethi S, Mϋller M, Schneider A, Blettner M, Smith E, Turek L, et al. Serologic response to the E4, E6 and E7 proteins of human papillomavirus type 16 in pregnant women. Am J Obstet Gynecol 1998; 178: 360-364. [DOI:10.1016/S0002-9378(98)80026-4]
8. Banura C, Franceschi S, van Doorn LJ, Arsian A, Kleter B, Wabwire-Mangen F, et al. Prevalence, incidence and clearance of human papillomavirus infection among young primiparous pregnant women in Kampala Uganda. Int J Cancer 2008; 123: 2180-2187. [DOI:10.1002/ijc.23762] [PMID]
9. Schiffman M, Clifford G, Buonaguro FM. Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline. Infect Agent Cancer 2009; 4: 1-8. [DOI:10.1186/1750-9378-4-8] [PMID] [PMCID]
10. Hernández-Girón C, Smith JS, Lorincz A, Arreola Cháidez E, Lazcano E, Hernández-Avila M, et al. The prevalence of high-risk HPV infection in pregnant women from Morelos, México. Salud Publica Mex 2005; 47: 423-429. [DOI:10.1590/S0036-36342005000600006] [PMID]
11. Hernández-Girón C, Smith JS, Lorincz A, Lazcano E, Hernández-Avila M, Salmerón J. High-risk human papillomavirus detection and related risk factors among pregnant and nonpregnant women in Mexico. Sex Transm Dis 2005; 32: 613-618. [DOI:10.1097/01.olq.0000179888.47309.db] [PMID]
12. Gajewska M, Marianowski L, Wielgos M, Malejczyk M, Majewski S. The occurrence of genital types of human papillomavirus in normal pregnancy and in pregnant women with pregestational insulin dependent diabetes mellitus. Neuro Endocrinol Lett 2005; 26: 766-770.
13. Fife KH, Katz BP, Roush J, Handy VD, Brown DR, Hansell R. Cancer-associated human papillomavirus types are selectively increased in the cervix of women in the first trimester of pregnancy. Am J Obstet Gynecol 1996; 174: 1487-1493. [DOI:10.1016/S0002-9378(96)70593-8]
14. Morrison EA, Gammon MD, Goldberg GL, Vermund SH, Burk RD. Pregnancy and cervical infection with human papillomaviruses. Int J Gynaecol Obstet 1996; 54: 125-130. [DOI:10.1016/0020-7292(96)02694-X]
15. Liu P, Xu L, Sun Y, Wang Z. The prevalence and risk of human papillomavirus infection in pregnant women. Epidemiol Infect 2014; 142: 1567-1578. [DOI:10.1017/S0950268814000636] [PMID]
16. Nobbenhuis MA, Helmerhorst TJ, van den Brule AJ, Rozendaal L, Bezemer PD, Voorhorst FJ, et al. High-risk human papillomavirus clearance in pregnant women: trends for lower clearance during pregnancy with a catch-up postpartum. Br J Cancer 2002; 87: 75-80. [DOI:10.1038/sj.bjc.6600367] [PMID] [PMCID]
17. Tarney CM, Beltran TA, Klaric J, Han JJ. Tobacco use and prevalence of human papillomavirus in self-collected cervicovaginal swabs between 2009 and 2014. Obstet Gynecol 2018; 132: 45-51. [DOI:10.1097/AOG.0000000000002681] [PMID]
18. Silva KC, Rosa ML, Moyse N, Afonso LA, Oliveira LH, Cavalcanti SM. Risk factors associated with human papillomavirus infection in two populations from Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz 2009; 104: 885-891. [DOI:10.1590/S0074-02762009000600011] [PMID]
19. Lee H, Lee DH, Song YM, Lee K, Sung J, Ko G. Risk factors associated with human papillomavirus infection status in a Korean cohort. Epidemiol Infect 2014; 142: 1579-1589. [DOI:10.1017/S0950268813002549] [PMID]
20. Chan PK, Chang AR, Tam WH, Cheung JL, Cheng AF. Prevalence and genotype distribution of cervical human papillomavirus infection: comparison between pregnant women and non-pregnant controls. J Med Virol 2002; 67: 583-588. [DOI:10.1002/jmv.10142] [PMID]
21. Yamasaki K, Miura K, Shimada T, Miura S, Abe S, Murakami M, et al. Epidemiology of human papillomavirus genotypes in pregnant Japanese women. J Hum Genet 2011; 56: 313-315. [DOI:10.1038/jhg.2011.11] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
