Volume 18, Issue 1 (January 2020)                   IJRM 2020, 18(1): 57-64 | Back to browse issues page

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Najib F, poordast T, Rezvan Nia M, Dabbaghmanesh M H. Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized controlled trial. IJRM 2020; 18 (1) :57-64
URL: http://ijrm.ir/article-1-1104-en.html
Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized controlled trial
Fatemesadat Najib1 , Tahereh Poordast1 , Mina Rezvan Nia * 2, Mohammad Hossein Dabbaghmanesh3
1- Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. , dr.rezvannia@yahoo.com
3- Endocrin and Metabolic Research center of Internal Medicine Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (2433 Views)
Abstract
Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).
Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.
Materials and Methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100µg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.
Results: The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).
Conclusion: The results of this trial suggest that supplementation with 100µg of selenium does not modulate glucose homeostasis in women with GDM.
Keywords: Diabetes, Gestational, Selenium
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Type of Study: Original Article | Subject: Pregnancy Health
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