Volume 17, Issue 12 (December 2019)                   IJRM 2019, 17(12): 929-934 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Bagchi B, Chatterjee S, Gon Chowdhury R. Role of latent female genital tuberculosis in recurrent early pregnancy loss: A retrospective analysis. IJRM 2019; 17 (12) :929-934
URL: http://ijrm.ir/article-1-1415-en.html
Role of latent female genital tuberculosis in recurrent early pregnancy loss: A retrospective analysis
Bishista Bagchi1 , Siddhartha Chatterjee * 2, Rajib Gon Chowdhury1
1- Department of Reproductive Medicine, Calcutta Fertility Mission, Kolkata, India
2- Department of Reproductive Medicine, Calcutta Fertility Mission, Kolkata, India , sidchat54@gmail.com
Abstract:   (3164 Views)

Background: Latent Female Genital tuberculosis (FGTB) or tubercular infestation is prevalent in Southeast Asia and even the presence of tubercular bacilli in the genital tract is becoming an important factor for reproductive failure. An immature endometrium becomes non-receptive, preventing implantation or rejection of implanted embryo in early months, resulting in recurrent pregnancy loss (RPL) in association with other factors.
Objective: To detect the underlying causes of RPL in addition to the proven causes like uterine cavity defects, thrombophilia, chromosomal abnormalities, etc.
Materials and Methods: 317 women with RPL, enrolled over a period of 60 months (January 2014 to December 2018) conducted at Calcutta Fertility Mission in the present study. They were grouped in A, B, and C and undergone routine tests for the same along with the PCR test with an endometrial aspirate.
Results: Patients with only latent FGTB (Group A), patients with FGTB and associated factors (Group B), and patients with other causes of RPL (other than latent FGTB) (Group C) were34.4%, 42.3%, and 23.3% respectively. About 29.36%, 47.01%, and 21.62%of the patients had achieved pregnancy in Group A, B, and C, respectively. The rate of miscarriage was high in both Groups A and B, affected with latent FGTB, and live-birth was higher (75%) in Group C that did not have tubercular involvement of the genital tract.
Conclusion: The tubercular infestation or latent FGTB as per our study appears to be a very important cause of RPL in patients with recurrent “unexplained” miscarriage. It should be treated adequately at an early stage to prevent permanent damage to pelvic organs and restore reproductive health in women.
 

Keywords: Female genital tuberculosis, Recurrent pregnancy loss, Endometrium, Implantation
Full-Text [PDF 264 kb]   (912 Downloads) |   |   Full-Text (HTML)  (523 Views)  
Type of Study: Original Article | Subject: Reproductive Biology
References
1. Sharma JB, Sharma E, Sharma S, Dharmendra S. Female genital tuberculosis: Revisited. Indian J Med Res 2018; 148 (Suppl.): S71-S83.
2. Mahajan N, Naidu P, Kaur SD. Insight into the diagnosis and management of subclinical genital tuberculosis in women with infertility. J Hum Reprod Sci 2016; 9:135-144. [DOI:10.4103/0974-1208.192043] [PMID] [PMCID]
3. Datta A, Chaudhuri AR, Chatterjee S, Chowdhury RG, Bhattacharya B. Roleof endometrial cytokines of the female genital tract tuberculosis in the context of infertility. BLDE University Journal of Health Sciences 2018; 3: 24-30. [DOI:10.4103/bjhs.bjhs_1_18]
4. Gon Chowdhury R, Paine SK, Bhattacharjee B, Chatterjee S. Infestation of endometrium by Mycobacterium tuberculosis Bacilli cause of reproductive failure. Al Ameen J Med Sci 2010; 3: 322-331.
5. Shahzad S. Investigation of the prevalence of female genital tract tuberculosis and its relation to female infertility: An observational analytical study. Iran J Reprod Med 2012; 10: 581-588.
6. Singh S, Gupta V, Modi S, Rana P, Duhan A, Sen R. Tuberculosis of uterine cervix: a report of two cases with variable clinical presentation. Trop Doct 2010; 40: 125-126. [DOI:10.1258/td.2009.090423] [PMID]
7. Ishrat S, Fatima P. Genital tuberculosis in the infertile women - an update. Mymensingh Med J 2015; 24: 215-220.
8. Yue J, Zhang B, Wang M, Yao J, Zhou Y, Ma D, et al. Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis. Front Med 2019; 13: 121-125. [DOI:10.1007/s11684-018-0615-2] [PMID]
9. Mondal SK, Dutta TK. A ten year clinicopathological study of female genital tuberculosis and impact on fertility. J Nepal Med Assoc 2009; 48: 52-57. [DOI:10.31729/jnma.202]
10. Paine SK, Basu A, Choudhury RG, Bhattacharya B, Chatterjee S, Bhattacharya C. Multiplex PCR from menstrual blood: a non-invasive cost-effective approach toreduce diagnostic dilemma for genital tuberculosis. Mol Diagn Ther 2018; 22: 391-396. [DOI:10.1007/s40291-018-0322-3] [PMID]
11. Al eryani AA, Saleh Abdelrub A, Al Harazi AH. Genital tuberculosis is common among females with tubal factor infertility: Observational study. Alexandria Journal of Medicine 2015; 51: 321-324. [DOI:10.1016/j.ajme.2014.11.004]
12. Jindal UN, Verma S, Bala Y. Favorable infertility outcomes following anti-tubercular treatment prescribed on the sole basis of a positive polymerase chain reaction test for endometrial tuberculosis. Hum Reprod 2012; 27: 1368-1374. [DOI:10.1093/humrep/des076] [PMID]
13. Naredi N, Talwar P, Narayan N, Rai S, Vardhan Sh, Panda S. Spontaneous conception following anti-tubercular treatment for sub-fertile women with multiple imaging markers suggesting genital tuberculosis. Fertility Science and Research 2014; 1: 44-49.
14. Vado-Solís IA, Suárez-Solís V, Jiménez-Delgadillo B, Zavala-Velázquez JE, Segura-Correa JC. Toxoplasma gondii presence in women with spontaneous abortion in Yucatan, Mexico. J Parasitol 2013; 99: 383-385. [DOI:10.1645/GE-3189.1] [PMID]
15. Nasirpour H, Azari Key Y, Kazemipur N, Majidpour M, Mahdavi S, Hajazimian S, et al. Association of rubella, cytomegalovirus, and toxoplasma infections with recurrent miscarriages in bonab-Iran: A case-control study. Gene Cell and Tissue 2017; 4: e60891. [DOI:10.5812/gct.60891]
16. El Hachem H, Crepaux V, May-Panloup P, Descamps P, Legendre G, Bouet PE. Recurrent pregnancy loss: current perspectives. Int J Womens Health 2017; 9: 331-345. [DOI:10.2147/IJWH.S100817] [PMID] [PMCID]
17. Grace GA, Devaleenal DB, Natrajan M. Genital tuberculosis in females. Indian J Med Res 2017; 145: 425-436.
18. Van Niekerk EC, Siebert I, Kruger TF. An evidence-based approach to recurrent pregnancy loss. SAJOG 2013; 19: 61-65. [DOI:10.7196/sajog.670]
19. Cakmak H, Taylor HS. Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update 2011; 17: 242-253. [DOI:10.1093/humupd/dmq037] [PMID] [PMCID]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb