Volume 18, Issue 5 (May 2020)                   IJRM 2020, 18(5): 367-374 | Back to browse issues page

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Novia D, Putri Lubis H, Halim B, Pustimbara A, Lestari R, Abinawanto A et al . The impact of late follicular progesterone level on in vitro fertilization-intracytoplasmic sperm injection outcome: Case-control study. IJRM 2020; 18 (5) :367-374
URL: http://ijrm.ir/article-1-1419-en.html
The impact of late follicular progesterone level on in vitro fertilization-intracytoplasmic sperm injection outcome: Case-control study
Diana Novia1 , Hilma Putri Lubis2 , Binarwan Halim2 , Anantya Pustimbara3 , Retno Lestari3 , Abinawanto Abinawanto3 , Anom Bowolaksono * 4
1- Department of Biology, Faculty of Mathematics and Science, University of Indonesia, Depok, Indonesia. Halim Fertility Center, Stella Maris Women and Children Hospital, Medan, Indonesia.
2- Halim Fertility Center, Stella Maris Women and Children Hospital, Medan, Indonesia. Faculty of Medicine University of Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia.
3- Department of Biology, Faculty of Mathematics and Science, University of Indonesia, Depok, Indonesia.
4- Department of Biology, Faculty of Mathematics and Science, University of Indonesia, Depok, Indonesia. , alaksono@sci.ui.ac.id
Abstract:   (2420 Views)
Background: Studies have been conducted to improve the pregnancy rate through the in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) program. In recent years, researchers have been focusing on finding impact of high progesterone level on endometrial receptivity. However, data on whether progesterone level also affects the quality of the embryo is still limited.
Objective: The aim is to assess the effect of late follicular progesterone level on the outcome of in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI).
Materials and Methods: This was a case-control of 245 women who underwent in vitro fertilization cycle at Halim Fertility Center, Indonesia. The outcomes assessed were number of oocytes retrieved (OR), maturation rate (MR), fertilization rate (FR), number of good embryos (GE), number of fair embryos (FE), and number of poor embryos (PE). The progesterone (P4) and estradiol (E2) levels were analyzed on the day of human chorionic gonadotropin injection. Serum progesterone level was divided into three groups: 1. low progesterone (≤ 0.50 ng/ml), 2. normal progesterone (0.51-1.50 ng/ml), and 3. high progesterone (> 1.50 ng/ml). All outcomes were compared amongst the groups.
Results: Significant differences occurred between progesterone level on the day of human chorionic gonadotropin administration. The number of OR in group 1, 2, and 3 were 8.41 ± 5.88 vs. 12.99 ± 8.51 vs. 17.58 ± 9.52, respectively.
Conclusion: Progesterone level on the day of human chorionic gonadotropin injection may have an impact on the outcome of IVF-ICSI.
 
Keywords: Intracytoplasmic sperm injection, Embryo, Progesterone, In vitro fertilization.
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Type of Study: Original Article | Subject: Assisted Reproductive Technologies
References
1. Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The international glosarry on infertility and fertility care, 2017. Fertil Steril 2017; 108: 393-406. [DOI:10.1016/j.fertnstert.2017.06.005] [PMID]
2. Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem 2018; 62: 2-10. [DOI:10.1016/j.clinbiochem.2018.03.012] [PMID]
3. Persson J. The ART of assisted reproductive technology. Aust Fam Physician 2005; 34: 119-122.
4. Lestari L, Pratama G, Maidarti M, Harzif AK, B. Wiweko. Characteristic and pregnancy rate of IVF patient: A retrospective analysis from two centres. ASPIRE conference proceedings, the 6th congress of the asia pacific initiative on reproduction, KnE Medicine 2016: 43-48.
5. Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile female: a committee opinion. Fertil Steril 2015; 103: 44-50. [DOI:10.1016/j.fertnstert.2015.03.019]
6. Santos-Ribeiro S, Polyzos NP, Haentjens P, Smitz J, Camus M, Tournaye H, et al. Live birth rates after IVF are reduced by both low and high progesterone levels on the day of human chorionic gonadotrophin administration. Hum Reprod 2014; 29: 1698-1705. [DOI:10.1093/humrep/deu151] [PMID]
7. Lawrenz B, Fatemi HM. Effect of progesterone elevation in follicular phase of IVF-cycles on the endometrial receptivity. Reprod Biomed Online 2017; 34: 422-428. [DOI:10.1016/j.rbmo.2017.01.011] [PMID]
8. Segal S, Glatstein I, McShane P, Hotamisligil S, Ezcurra D, Carson R. Premature luteinization and in vitro fertilization outcome in gonadotropin/gonadotropin-releasing hormone antagonist cycles in women with polycystic ovary syndrome. Fertil Steril 2009; 91: 1755-1759. [DOI:10.1016/j.fertnstert.2008.02.009] [PMID]
9. Huang B, Li Z, Zhu L, Hu D, Liu Q, Zhu G, et al. Progesterone elevation on the day of HCG administration may affect rescue ICSI. Reprod Biomed Online 2014; 29: 88-93. [DOI:10.1016/j.rbmo.2014.03.015] [PMID]
10. M. Choudhary, Sharma S, Swarankar M L, Bhardwaj S L. Risk of premature luteinization in IVF cycles and its impact on clinical pregnancy rate. Int J Res Med Sci 2016; 4: 139-143. [DOI:10.18203/2320-6012.ijrms20160020]
11. Lawrenz B, Labarta E, Fatemi H, Bosch E. Premature progesterone elevation: targets and rescue strategies. Fertil Steril 2018; 109: 577-582. [DOI:10.1016/j.fertnstert.2018.02.128] [PMID]
12. Liu Y, Copeland C, Chapple V, Roberts P, Feenan K, Matson P. The relationship between embryo quality assessed using routine embryology or time-lapse videography and serum progesterone concentration on the day of ovulatory trigger in in vitro fertilization cycles. Asian Pacific Journal of Reproduction 2015; 4: 140-146. [DOI:10.1016/S2305-0500(15)30011-7]
13. Sonigo C, Dray G, Roche C, Cédrin-Durnerin I, Hugues JN. Impact of high serum progesterone during the late follicular phase on IVF outcome. Reprod Biomed Online 2014; 29: 177-186. [DOI:10.1016/j.rbmo.2014.03.027] [PMID]
14. Alpha scientists in reproductive medicine and ESHRE special interest group of embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 2011; 26: 1270-1283. [DOI:10.1093/humrep/der037] [PMID]
15. Trounson A, Gosden R, Eichenlaub-Ritter U. Second edition biology and pathology of the oocyte role in fertility, medicine, and nuclear reprogramming. Cambridge University Press, New York; 2013. [DOI:10.1017/CBO9781139135030]
16. Abbara A, Clarke SA, Dhillo WS. Novel concepts for inducing final oocyte maturation in in vitro fertilization treatment. Endocr Rev 2018; 39: 593-628. [DOI:10.1210/er.2017-00236] [PMID] [PMCID]
17. Rehman R, Khan R, Baig M, Hussain M, Fatima SS. Estradiol progesterone ratio on ovulation induction day: a determinant of successful pregnancy outcome after intra cytoplasmic sperm injection. Iran J Reprod Med 2014; 12: 633-640.
18. Bu Z, Zhao F, Wang K, Guo Y, Su Y, Zhai J, et al. Serum progesterone elevation adversely affects cumulative live birth rate in different ovarian responders during in vitro fertilization and embryo transfer: a large retrospective study. PloS One 2014; 9: e100011. [DOI:10.1371/journal.pone.0100011] [PMID] [PMCID]
19. Hoshino Y. Updating the markers for oocyte quality evaluation: intracellular temperature as a new index. Reprod Med Biol 2018; 17: 434-441. [DOI:10.1002/rmb2.12245] [PMID] [PMCID]
20. Huang B, Ren X, Wu L, Zhu L, Xu B, Li Y, et al. Elevated progesterone levels on the day of oocyte maturation may affect top quality embryo IVF cycles. PLoS One 2016; 11: e0145895. [DOI:10.1371/journal.pone.0145895] [PMID] [PMCID]
21. Huang PC, Chen MJ, Guu HF, Yi YC, Ho JY, Chen YF, et al. Effect of premature serum progesterone rise on embryo transfer outcomes and the role of blastocyst culture and transfer in assisted reproductive technology cycles with premature progesterone rise. Taiwan J Obstet Gynecol 2015; 54: 641-646. [DOI:10.1016/j.tjog.2014.03.014] [PMID]
22. Huang Y, Wang EY, Du QY, Xiong YJ, Guo XY, Yu YP, et al. Progesterone elevation on the day of human chorionic gonadotropin administration adversely affects the outcome of IVF with transferred embryos at different developmental stages. Reprod Biol Endocrinol 2015; 13: 82-91. [DOI:10.1186/s12958-015-0075-3] [PMID] [PMCID]
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