International Journal of
Reproductive Biomedicine
Mon, Oct 7, 2024
[Archive]
Volume 19, Issue 1 (January 2021)
IJRM 2021, 19(1): 57-62 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mohammad jafari R, Zargar M, Barati M, Ershadian S. The comparison of predictive value of cervical length in singleton spontaneous preterm labor with in vitro fertilization pregnancies: A cohort study. IJRM 2021; 19 (1) :57-62
URL: http://ijrm.ir/article-1-1435-en.html
URL: http://ijrm.ir/article-1-1435-en.html
1- Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,dr.ershadian@gmail.com
2- Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,
Abstract: (1611 Views)
Background: Preterm labor (PTL) is one of the most important factors in neonatal mortality. Some studies have revealed a reverse relationship between cervical length (CL) and PTL, however, further evidence is needed to confirm it.
Objective: To investigate the predictive value of CL in spontaneous and in vitro fertilization (IVF) pregnancies.
Materials and Methods: This prospective cohort study was performed on 154 pregnant women from 16-26 wk of gestation with singleton fetus in spontaneous delivery (n = 77) and IVF pregnancies (n = 77) and followed up until delivery. Women with multiple pregnancy, placenta previa, cerclage, and congenital anomalies were excluded from study. The cut-off determination was done according to the Roc analysis.
Results: The mean CL in term delivery and PTL groups were 37 ± 7 mm and 31 ± 6 mm, respectively (p < 0.001). The frequency of PTL in spontaneous and IVF pregnancies were 7.8% and 23.27%, respectively (p = 0.007). According to the Roc analysis, the best cut-off for normal pregnancy was ≤36 mm with the negative predictive value of 97.9%, the positive predictive value of 11.4%, sensitivity 83.3%, and specificity of 46.5%. While for the IVF group, the cut off was ≤30 mm, with a negative predictive value of 88.4%, positive predictive value of 57.8%, sensitivity of 63.2%, and specificity of 86%.
Conclusion: In this study, IVF had a significant direct correlation with PTL. CL also had a significant indirect relationship with PTL.
Objective: To investigate the predictive value of CL in spontaneous and in vitro fertilization (IVF) pregnancies.
Materials and Methods: This prospective cohort study was performed on 154 pregnant women from 16-26 wk of gestation with singleton fetus in spontaneous delivery (n = 77) and IVF pregnancies (n = 77) and followed up until delivery. Women with multiple pregnancy, placenta previa, cerclage, and congenital anomalies were excluded from study. The cut-off determination was done according to the Roc analysis.
Results: The mean CL in term delivery and PTL groups were 37 ± 7 mm and 31 ± 6 mm, respectively (p < 0.001). The frequency of PTL in spontaneous and IVF pregnancies were 7.8% and 23.27%, respectively (p = 0.007). According to the Roc analysis, the best cut-off for normal pregnancy was ≤36 mm with the negative predictive value of 97.9%, the positive predictive value of 11.4%, sensitivity 83.3%, and specificity of 46.5%. While for the IVF group, the cut off was ≤30 mm, with a negative predictive value of 88.4%, positive predictive value of 57.8%, sensitivity of 63.2%, and specificity of 86%.
Conclusion: In this study, IVF had a significant direct correlation with PTL. CL also had a significant indirect relationship with PTL.
Type of Study: Original Article |
Subject:
Fertility & Infertility
References
1. Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G. Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data. Ultrasound Obstet Gynecol 2017; 49: 322-329. [DOI:10.1002/uog.17388] [PMID]
2. Sharvit M, Weiss R, Ganor Paz Y, Tzadikevitch Geffen K, Danielli Miller N, Biron-Shental T. Vaginal examination vs. cervical length - which is superior in predicting preterm birth?. J Perinat Med 2017; 45: 977-983. [DOI:10.1515/jpm-2016-0273] [PMID]
3. Leitich H, Brunbauer M, Kaider A, Egarter Ch, Husslein P. Cervical length and dilatation of the internal cervical os detected by vaginal ultrasonography as markers for preterm delivery: A systematic review. Am J Obstet Gynecol 1999; 181: 1465-1472. [DOI:10.1016/S0002-9378(99)70407-2]
4. Saccone G, Zullo F, Roman A, Ward A, Maruotti G, Martinelli P, et al. Risk of spontaneous preterm birth in IVF-conceived twin pregnancies. J Matern Fetal Neonatal Med 2017; 32: 369-376. [DOI:10.1080/14767058.2017.1378339] [PMID]
5. Qin J, Liu X, Sheng X, Wang H, Gao Sh. Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies. Fertil Steril 2016; 105: 73-85.
https://doi.org/10.1016/j.fertnstert.2015.12.131 [DOI:10.1016/j.fertnstert.2015.09.007]
6. Kim D, Saada A. The social determinants of infant mortality and birth outcomes in Western developed nations: a cross-country systematic review. Int J Environ Res Public Health 2013; 10: 2296-2335. [DOI:10.3390/ijerph10062296] [PMID] [PMCID]
7. Cavoretto P, Candiani M, Giorgione V, Inversetti A, Abu-Saba MM, Tiberio F, et al. Risk of spontaneous preterm birth in singleton pregnancies conceived after IVF/ICSI treatment: meta-analysis of cohort studies. Ultrasound Obstet Gynecol 2018; 51: 43-53. [DOI:10.1002/uog.18930] [PMID]
8. Mohamadjafari R, Nagafian M, Vahaby E, Gharibzadeh S. [Correlation between cervical length by transvaginal sonography at 16-24wks of pregnancy and preterm labor.] Stud Med Sci 2013; 24: 441-448. (in Persian)
9. Pasquini L, Sisti G, Nasioudis D, Kanninen T, Sorbi F, Fambrini M, et al. Ability of cervical length to predict spontaneous preterm delivery in twin pregnancies using the receiver-operating characteristic curve analysis and an a priori cut-off value. J Obstet Gynaecol 2017; 37: 562-565. [DOI:10.1080/01443615.2016.1258046] [PMID]
10. Szymusik I, Wegrzyn P, Marianowski P, Dziadecki W, Bablok L, Wielgos M. Is mid-gestational cervical length measurement as sensitive prediction factor of preterm delivery in IVF as in spontaneous singleton pregnancies? Neuro Endocrinol Lett 2011; 32: 453-457.
11. Al-Safi ZA, Shavell VI, Roberts RP, Singh M, Puscheck EE, Diamond MP. First trimester cervical length and preterm delivery in pregnancies conceived through in vitro fertilization. Fertil Steril 2011; 96: S13. [DOI:10.1016/j.fertnstert.2011.07.057]
12. Berghella V, Baxter JK, Hendrix NW. Cervical assessment by ultrasound for preventing preterm delivery. Cochrane Database Syst Rev 2009; 2: CD007235. [DOI:10.1002/14651858.CD007235.pub2]
13. O'Hara S, Zelesco M, Sun Z. Cervical length for predicting preterm birth and a comparison of ultrasonic measurement techniques. Aust J Ultrasound Med 2013; 16: 124-134. [DOI:10.1002/j.2205-0140.2013.tb00100.x] [PMID] [PMCID]
14. Iams JD, Goldenberg RL, Meis PJ, Mercer BM, Moawad A, Das A, et al. The length of the cervix and the risk of spontaneous premature delivery. N Engl J Med 1996; 334: 567-572. [DOI:10.1056/NEJM199602293340904] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
