Volume 18, Issue 12 (December 2020)                   IJRM 2020, 18(12): 1029-1038 | Back to browse issues page

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Aslfalah H, Jamilian M, Ansarihadipour H, Abdollahi M, Khosrowbeygi A. Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study. IJRM 2020; 18 (12) :1029-1038
URL: http://ijrm.ir/article-1-1473-en.html
Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study
Hadise Aslfalah1 , Mehri Jamilian2 , Hadi Ansarihadipour3 , Mahdi Abdollahi4 , Ali Khosrowbeygi * 5
1- Students Research Committee, Arak University of Medical Sciences, Arak, Iran.
2- Department of Gynecology and Obstetrics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
3- Department of Biochemistry and Genetics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
4- Decorative and Hygienic Products, Control Laboratory of Food, Beverage, Food and Drug Administration, Arak University of Medical Sciences, Arak, Iran.
5- Department of Biochemistry and Genetics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran. , khosrowbeygi@yahoo.com
Abstract:   (2323 Views)
Background: Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases.
Objective: To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM.
Materials and Methods: Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value < 0.05 was considered as statistically significant.
Results: The values of TyG index (p < 0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Conclusion: Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM.
Keywords: Lipoic acid, Gestational diabetes, Lipids, Triglycerides, Cholesterol.
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Type of Study: Original Article | Subject: Pregnancy Health
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