Volume 18, Issue 8 (August 2020)                   IJRM 2020, 18(8): 605-610 | Back to browse issues page

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Mercy Sylus A, Nandeesha H, Thiagaraju C. Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study. IJRM 2020; 18 (8) :605-610
URL: http://ijrm.ir/article-1-1533-en.html
Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study
Angel Mercy Sylus1 , Hanumanthappa Nandeesha * 2, Chitra Thiagaraju3
1- Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
2- Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India. , nandijipmer@gmail.com
3- Obstetrics and Gynecology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
Abstract:   (1931 Views)
Background: Obesity, inflammation and alterations in matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary syndrome (PCOS).
Objective: To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with the increase in body mass index (BMI) in women with PCOS.
Materials and Methods: Sixty two infertile PCOS women were included in the study. Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in BMI.
Results: MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP-9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was also found in the PCOS subjects.
Conclusion: MMP-9 levels are increased in obese PCOS women and it is associated with NO levels and the duration of infertility.
 

 
Keywords: Body mass index, Interleukin-10, Nitric oxide, Matrix metalloproteinase-9.
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Type of Study: Original Article | Subject: Reproductive Biology
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