Volume 7, Issue 4 (7-2009)                   IJRM 2009, 7(4): 153-156 | Back to browse issues page

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Vahid Roudsari F, Ayati S, Ayatollahi H, Esmaeily H, Hasanzadeh M, Shahabian M et al . Comparison of maternal serum Tumor Necrosis Factor-alpha (TNF-α) in severe and mild preeclampsia versus normal pregnancy. IJRM 2009; 7 (4) :153-156
URL: http://ijrm.ir/article-1-158-en.html
Comparison of maternal serum Tumor Necrosis Factor-alpha (TNF-α) in severe and mild preeclampsia versus normal pregnancy
Fatemeh Vahid Roudsari1 , Sedigheh Ayati * 2, Hossein Ayatollahi3 , Habibollah Esmaeily4 , Maliheh Hasanzadeh1 , Masoud Shahabian1 , Leila Pour Ali1
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Obstetrics and Gynecology, Ghaem Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , ayatis@mums.ac.ir
3- Department of Hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Medicosocial, Ghaem Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (2693 Views)
Background: Preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. It is suggested that cytokines such as Tumor Necrosis Factor-alpha (TNF-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction.
Objective: The aim of this study was comparison of maternal serum TNF-α in severe and mild preeclampsia versus normal pregnancy.
Materials and Methods: This study was performed on 37 women with preeclampsia (17 mild and 20 severe preeclampsia) and 41 normotensive pregnant women with similar gestational age at third trimester of pregnancy. All the preeclamptic cases had blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg in a 24-h urine sample. Maternal serum TNF-α concentration was compared in all of them.
Results: The level of TNF-α concentration was not statistically different between the studied groups. No significant correlation was found between preeclampsia and control group as they were compared in the view of maternal serum TNF-α concentration.
Conclusion: These findings suggest that serum TNF-α is not significantly associated with preeclampsia.
Keywords: Tumor Necrosis Factor-alpha (TNF-α), Preeclampsia, Normal pregnancy
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Type of Study: Original Article |
References
1. Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 2005; 193: 860-863. [DOI:10.1016/j.ajog.2005.06.058]
2. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. Williams Obstetrics. 22th ed. Philadelfia: McGraw Hill; 2005: 765-768.
3. Vahid Roudsari F, Ayati S, Torabizadeh A, Ayatollahi H, Esmaeli H, Shahabian M. Serum calcium and magnesium in preeclamptic and normal pregnancies; A comparative study. Journal of Reproduction & Infertility 2008; 9: 256-262.
4. Mirahmadian M, Kalantar F, Heidari G, Safdarian L, Mansouri R, Amirzargar AA. Association of tumor necrosis factor-alpha and interlukine-10 gene polymorphisms in Iranian patients with preeclampsia. Am J Reprod Immunol 2008; 60: 179- 185. [DOI:10.1111/j.1600-0897.2008.00610.x]
5. Gulti R. Raised serum TNF-alpha, blood sugar and uric asid in preeclampsia in third trimester of pregnancy. J Nep Med Assoc 2005; 44: 36-38. [DOI:10.31729/jnma.393]
6. Sibai BM. Immunological aspects of preeclampsia. Clin Obstet Gynaecol 1991; 34: 27-34. [DOI:10.1097/00003081-199103000-00007]
7. Tranchot-Diallo J, Gras G, Parnet-Mathieu f, Benveniste O, Marce D, Roques P, et al. Modulations of cytokine expression in pregnant women. Am J Reprod Immunol 1997; 37: 215-226. [DOI:10.1111/j.1600-0897.1997.tb00218.x]
8. Kaumma S, Matt D, Sytrom S, Eierman D, Turner T. Interlukin-1beta, human leukocyte antigen HLA-DR alpha, and transforming growth factor-beta expression in endometrium, placenta and placental membranes. Am J Obstet Gynecol 1990; 163: 1430-1437. [DOI:10.1016/0002-9378(90)90601-3]
9. Hunt JS. Cytokines network in uteroplacental unit, macrophages as pivotal regulatory cell. J Reprod Immunol 1989; 16: 1-17. [DOI:10.1016/0165-0378(89)90002-8]
10. Ari KI, Lee F, Miyajima A, Miyatake S, Ari N, Yokata T. Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem 1990; 59: 783-836. [DOI:10.1146/annurev.bi.59.070190.004031]
11. Sharma A, Satyam A, Sharma JB. Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women. Am J Reprod Immunol 2007; 58: 21-30. [DOI:10.1111/j.1600-0897.2007.00486.x]
12. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986; 163:740-745. [DOI:10.1084/jem.163.3.740]
13. Kupfermink MJ, Peaceman AM, Wington TR, Tamura RK, Rehnberg KA, Socol ML. Immunoreactive tumor necrosis factor-alpha is elevated in maternal plasma but undetected in amniotic fluid in the second trimester. Am J Obstet Gynecol 1994; 171: 976-979. [DOI:10.1016/0002-9378(94)90017-5]
14. Vallance P, Collier J, Bhagat K. Infection, inflammation and infraction: dose acute endothelial dysfunction provide a link? Lancet 1997; 349: 1391-1392. [DOI:10.1016/S0140-6736(96)09424-X]
15. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Mclaughlin MK, Hubel CA. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200-1204. [DOI:10.1016/0002-9378(89)90665-0]
16. Herrera JA, Chaudhuri G, Lopez-Jaramillo P. Is infection a major risk factor for preeclampsia? Med Hypotheses 2001; 57: 393-397. [DOI:10.1054/mehy.2001.1378]
17. Teran E, Escudero C, Moya W, Flores M, Vallance P, Lopez-Jaramillo P. Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with preeclampsia. Int J Gynecol Obstet 2001; 75: 243-249. [DOI:10.1016/S0020-7292(01)00499-4]
18. Tavakol Afshari J, Ghomian N, Shameli A, Shakeri MT, Fahmidehkar MA, Mahajer E, et al. Determination of interlukin-6 and tumor necrosis factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia. BMC Pregnancy and Childbirth 2005; 5: 14. [DOI:10.1186/1471-2393-5-14]
19. Kocyigity Y, Atamer Y, Atamer A, Tuzcu A, Akkus Z. Changes in serum levels of leptin, cytokines and lipoprotein in preeclamptic and normotensive pregnant women. Gynecol Endocrinol 2004; 19: 267-273. [DOI:10.1080/09513590400018108]
20. Hamai Y, Fujii T, Yamashita T, Nishina H, Kozuma S, Mikami Y et al. Evidence for an elevation in serum interlukine-2 and tumour necrosis factor-alpha levels before the clinical manifestations of preeclampsia. Am J Reprod Immunol 1997; 38: 89-93. [DOI:10.1111/j.1600-0897.1997.tb00281.x]
21. Omu AE, Al-Qattan F, Diejomach ME, Al-Yatama M. Differential levels of T helper cytokines in preeclampsia: pregnancy, labor and puerperium. Acta Obstet Gynecol Scand 1999; 78: 675-680. [DOI:10.1034/j.1600-0412.1999.780803.x]
22. Kupferminc MJ, Peaceman AM, Aderka D, Wallach D, Payser Mr, Lessing JB, Socol ML. Soluble tumor necrosis factor receptors in maternal plasma and second-trimester amniotic fluid. A J Obstet Gynecol 1995; 173: 900-905. [DOI:10.1016/0002-9378(95)90363-1]
23. Teran E, Escudero C, Moya W, Flores M, Vallance P, Lopez-Jaramillo P. Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with preeclampsia. Int J Gynaecol Obstet 2001; 75: 243-249. [DOI:10.1016/S0020-7292(01)00499-4]
24. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interlukin-6 and interlukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol 1994; 84: 937-940.
25. Heyl W, Handt S, Reister F, Gehlen J. Elevated soluble adhesion molecules in women with preeclampsia. Do cytokines like tumor necrosis factor-alpha and interlukin-1 beta cause endothelial activation. Eur J Obstet Gynecol Reprod Biol 1999; 86: 35-41. [DOI:10.1016/S0301-2115(99)00042-1]
26. Ellis J, Wennerholm UB, Bengtsson A, Lilja H, Pettersson A, Sultan B, et al . Levels of dimethyl-arginines and cytokines in mild and severe preeclampsia. Acta Obstet Gynecol Scand 2001; 80: 602-608. [DOI:10.1080/j.1600-0412.2001.800703.x]
27. Hill JA, Devoe LD, Bryans CI Jr. Frequency of asymptomatic bacteriuria in preeclampsia. Obstet Gynecol 1986; 67: 529-532.
28. Hsu CD, Witter FR. Urogenital infection in preeclampsia. Int J Gynecol Obstet 1995; 49: 271-275. [DOI:10.1016/0020-7292(95)02373-K]
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