Volume 19, Issue 1 (January 2021)                   IJRM 2021, 19(1): 5-22 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Raveendran A V, Agarwal A. Premature ejaculation - current concepts in the management: A narrative review. IJRM 2021; 19 (1) :5-22
URL: http://ijrm.ir/article-1-1612-en.html
Premature ejaculation - current concepts in the management: A narrative review
Arkiath Veettil Raveendran * 1, Ankur Agarwal2
1- Govt Medical College, Kozhikode, Kottayam, Manjeri, Kerala, India. , raveendranav@yahoo.co.in
2- Seceratory General for Asia Oceania Federation of Sexology, Hon. Treasurer for CSEPI, Sex Counselors and Therapists, Indore, India.
Abstract:   (2823 Views)
Premature ejaculation (PE; early ejaculation or rapid ejaculation) is a common sexual problem affecting about 20-30% of men in the sexually active age group. PE can be of four types: Primary, secondary, natural variable, and subjective PE. Various non-pharmacological and pharmacological treatment options are available to treat PE including Dapoxetine, which is specifically developed for the treatment of PE. In this review, we discuss the pathophysiology and management aspects of PE.
Keywords: Premature ejaculation, Cognitive behavioral therapy, Serotonin uptake inhibitors, Dapoxetine.
Full-Text [PDF 2238 kb]   (2219 Downloads) |   |   Full-Text (HTML)  (1422 Views)  
Type of Study: Review Article | Subject: Reproductive Andrology
References
1. Masters WH, Johnson VE. Human sexual inadequacy. London; Boston: Churchill; Little Brown, 1970.
2. Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JPW, Lue TF, et al. AUA guideline on the pharmacologic management of premature ejaculation. J Urol 2004; 172: 290-294. [DOI:10.1097/01.ju.0000132159.61156.ea] [PMID]
3. Serefoglu EC, McMahon ChG, Waldinger MD, Althof SE, Shindel A, Adaikan G, et al. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicinead hoc committee for the definition of premature ejaculation. Sex Med 2014; 2: 41-59. [DOI:10.1002/sm2.27] [PMID] [PMCID]
4. Giuliano F, Clement P. Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 2006; 50: 454-466. [DOI:10.1016/j.eururo.2006.05.055] [PMID]
5. Coolen LM, Allard J, Truitt WA, McKenna KE. Central regulation of ejaculation. Physiol Behav 2004; 83: 203-215. [DOI:10.1016/j.physbeh.2004.08.023] [PMID]
6. Alwaal A, Breyer BN, Lue TF. Normal male sexual function: emphasis on orgasm and ejaculation. Fertil Steril 2015; 104: 1051-1060. [DOI:10.1016/j.fertnstert.2015.08.033] [PMID] [PMCID]
7. Gillman N, Gillman M. Premature ejaculation: Aetiology and treatment strategies. Med Sci (Basel) 2019; 7: E102. [DOI:10.3390/medsci7110102] [PMID] [PMCID]
8. Giuliano F, Clèment P. Pharmacology for the treatment of premature ejaculation. Pharmacol Rev 2012; 64: 621-644. [DOI:10.1124/pr.111.004952] [PMID]
9. Giuliano, F, Clement P. Physiology of ejaculation: Emphasis on serotonergic control. Eur Urol 2005; 48: 408-417. [DOI:10.1016/j.eururo.2005.05.017] [PMID]
10. McMahon ChG, Samali R. Pharmacological treatment of premature ejaculation. Curr Opin Urol 1999; 9: 553-561. [DOI:10.1097/00042307-199911000-00011] [PMID]
11. Yehuda I. Pelvic floor involvement in male and female sexual dysfunction and the role of pelvic floor rehabilitationin treatment: a literature review. J Sex Med 2007; 4: 4-13. [DOI:10.1111/j.1743-6109.2006.00393.x] [PMID]
12. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M. Ejaculation disorders: A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2005; 2: 492-497. [DOI:10.1111/j.1743-6109.2005.00070.x] [PMID]
13. Dinsmore WW, Ralph DJ, Kell P, Wylie KR, Dean JP, Novak C, et al. Evaluation of the sexual assessment monitor, a diagnostic device used to electronically quantify ejaculatory latency time: findings from three studies. BJU Int 2006; 98: 613-618. [DOI:10.1111/j.1464-410X.2006.06286.x] [PMID]
14. Grenier G, Byers ES. The relationships among ejaculatory control, ejaculatory latency, and attempts to prolong heterosexual intercourse. Arch Sex Behav 1997; 26: 27-47. [DOI:10.1023/A:1024569319319] [PMID]
15. Giuliano F, Patrick DL, Porst H, La Pera G, Kokoszka A, Merchant S, et al. Premature ejaculation: results from a five-country European observational study. Eur Urol 2008; 53: 1048-1057. [DOI:10.1016/j.eururo.2007.10.015] [PMID]
16. Rowland DL. Psychological impact of premature ejaculation and barriers to its recognition and treatment. Curr Med Res Opin 2011; 27: 1509-1518. [DOI:10.1185/03007995.2011.590968] [PMID]
17. Althof SE, McMahon ChG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An update of the international society of sexual medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014; 2: 60-90. [DOI:10.1002/sm2.28] [PMID] [PMCID]
18. Waldinger MD. Recent advances in the classification, neurobiology and treatmentof premature ejaculation. Adv Psychosom Med 2008; 29: 50-69. [DOI:10.1159/000126624] [PMID]
19. Hu QB, Zhang D, Ma L, Ng DM, Haleem M, Ma Q. Progresses in pharmaceutical and surgical management of premature ejaculation. Chin Med J 2019; 132: 2362-2372. [DOI:10.1097/CM9.0000000000000433] [PMID] [PMCID]
20. Tsai WK, Chiang PK, Lu ChCh, Jiann BP. The comorbidity between premature ejaculation and erectile dysfunction-A cross-sectional internet survey. Sex Med 2019; 7: 451-458. [DOI:10.1016/j.esxm.2019.06.014] [PMID] [PMCID]
21. Kam SCh, Han DH, Lee SW. The diagnostic value of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. J Sex Med 2011; 8: 865-871. [DOI:10.1111/j.1743-6109.2010.02151.x] [PMID]
22. Melnik T, Althof S, Atallah AN, dos Santos Puga ME, Glina S, Riera R. Psychosocial interventions for premature ejaculation. Cochrane Database of Systematic Reviews 2011: CD008195. [DOI:10.1002/14651858.CD008195.pub2] [PMID]
23. Cooper K, Martyn-St James M, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, et al. Behavioral therapies for management of premature ejaculation: A systematic review. Sex Med 2015; 3: 174-188. [DOI:10.1002/sm2.65] [PMID] [PMCID]
24. Siegel AL. Pelvic floor muscle training in males: practical applications. Urology 2014; 84: 1-7. [DOI:10.1016/j.urology.2014.03.016] [PMID]
25. Pastore AL, Palleschi G, Leto A, Pacini L, Iori F, Leonardo C, et al. A prospective randomizedstudy to compare pelvic floor rehabilitation and dapoxetine for treatment of lifelong premature ejaculation. Int J Androl 2012; 35: 528-533. [DOI:10.1111/j.1365-2605.2011.01243.x] [PMID]
26. Porst H, Burri A. Novel treatment for premature ejaculation in the light of currently used therapies: A review. Sex Med Rev 2019; 7: 129-140. [DOI:10.1016/j.sxmr.2018.05.001] [PMID]
27. Martyn-St James M, Cooper K, Ren K, Kaltenthaler E, Dickinson K, Cantrell A, et al. Topical anaesthetics for premature ejaculation: a systematic review and meta-analysis. Sex Health 2016; 13: 114-123. [DOI:10.1071/SH15042] [PMID]
28. Butcher MJ, Serefoglu EC. Recent advances in the pharmacotherapy of premature ejaculation. EMJ Urol 2017; 5: 91-97.
29. Wong BLK, Malde S. The use of tramadol "on-demand" for premature ejaculation: A systematic review. Urology 2013; 81: 98-103. [DOI:10.1016/j.urology.2012.08.037] [PMID]
30. Gajjala SR, Khalidi A. Premature ejaculation: A review. Indian J Sex Transm Dis AIDS 2014; 35: 92-95. [DOI:10.4103/0253-7184.142391] [PMID]
31. Arafa M, Shamloul R. A randomized study examining the effect of 3 SSRI on premature ejaculation using a validated questionnaire. Ther Clin Risk Manag 2007; 3: 527-531.
32. Li J, Liu D, Wu J, Fan X, Dong Q. Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis. Ann Saudi Med 2018; 38: 366-375. [DOI:10.5144/0256-4947.2018.366] [PMID] [PMCID]
33. Du Y, Jiang Y, Zhang J, Tian G, Zhang N, Wu D, et al. Efficacy and safety of "on-demand" dapoxetine in treatment of patients with premature ejaculation: A meta-analysis. Med Sci Monit 2019; 25: 4225-4232. [DOI:10.12659/MSM.913606] [PMID] [PMCID]
34. Peng J, Fang D, Li H, Tang Y, Yuan Y, Cui W, et al. Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice. BMC Urol 2020; 20: 11-16. [DOI:10.1186/s12894-020-0580-3] [PMID] [PMCID]
35. Balci M, Atan A, Senel C, Guzel O, Aslan Y, Lokman U, et al. Comparison of the treatment efficacies of paroxetine, fluoxetine and dapoxetine in low socioeconomic status patients with lifelong premature ejaculation. Cent European J Urol 2019; 72: 185-190.
36. Krishnappa P, Fernandez-Pascual E, Carballido J, Martinez-Salamanca JI. Sildenafil/viagra in the treatment of premature ejaculation. Int J Impot Res 2019; 31: 65-70. [DOI:10.1038/s41443-018-0099-2] [PMID]
37. Jin K, Deng L, Qiu S, Tu X, Li J, Bao Y, et al. Comparative efficacy and safety of phosphodiesterase-5 inhibitors with selective serotonin reuptake inhibitors in men with premature ejaculation: A systematic review and Bayesian network meta-analysis. Medicine (Baltimore) 2018; 97: e13342. [DOI:10.1097/MD.0000000000013342] [PMID] [PMCID]
38. Sato Y, Tanda H, Nakajima H, Nitta T, Akagashi K, Hanzawa T, et al. Silodosin and its potential for treating premature ejaculation: a preliminary report. Int J Urol 2012; 19: 268-272. [DOI:10.1111/j.1442-2042.2011.02941.x] [PMID]
39. Abdallah H, Abdelnasser T, Hosny H, Selim O, Al-Ahwany A, Shamloul R. Treatment of premature ejaculation by glans penis augmentation using hyaluronic acid gel: A pilot study. Andrologia 2012; 44 (Suppl.): 650-653. [DOI:10.1111/j.1439-0272.2011.01244.x] [PMID]
40. Li ZhT, Li YF, Zhang Y, Luo Y, Zhu T, Li K, et al. [Injection of botulinum-A toxin into bulbospongiosus muscle for primary premature ejaculation: A preliminary clinical study]. Zhonghua Nan Ke Xue 2018; 24: 713-718. (in Chinese)
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb