Volume 18, Issue 9 (September 2020)                   IJRM 2020, 18(9): 693-700 | Back to browse issues page

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Davar R, Pourmasumi S, Mohammadi B, Mortazavi Lahijani M. The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial. IJRM 2020; 18 (9) :693-700
URL: http://ijrm.ir/article-1-1747-en.html
The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial
Robab Davar1 , Soheila Pourmasumi2 , Banafsheh Mohammadi1 , Maryam Mortazavi Lahijani * 3
1- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Clinical Research Development Unit (CRDU), Moradi Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Obstetrics and Gynecology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , m_mortazavi58@yahoo.com
Abstract:   (4852 Views)
Background: The results of previous studies on the effect of low-dose aspirin in frozen-thawed embryo transfer (FET) cycles are limited and controversial.
Objective: To evaluate the effect of low-dose aspirin on the clinical pregnancy in the FET cycles.
Materials and Methods: This study was performed as a randomized clinical trial from May 2018 to February 2019; 128 women who were candidates for the FET were randomly assigned to two groups receiving either 80 mg oral aspirin (n = 64) or no treatment. The primary outcome was clinical pregnancy rate and secondary outcome measures were the implantation rate, miscarriage rate, and endometrial thickness.
Results: The endometrial thickness was lower in patients who received aspirin in comparison to the control group. There were statistically significant differences between the two groups (p = 0.018). Chemical and clinical pregnancy rates and abortion rate was similar in the two groups and there was no statistically significant difference.
Conclusion: The administration of aspirin in FET cycles had no positive effect on the implantation and the chemical and clinical pregnancy rates, which is in accordance with current Cochrane review that does not recommend aspirin administration as a routine in assisted reproductive technology cycles.
Keywords: Aspirin, Embryo transfer, Pregnancy rates.
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Type of Study: Original Article | Subject: Fertility & Infertility
References
1. de Mola JRL. Principles and practice of assisted reproductive technology. Fertility and Sterility 2014; 102: 610. [DOI:10.1016/j.fertnstert.2014.06.018]
2. Pakkila M, Rasanen J, Heinonen S, Tinkanen H, Tuomivaara L, Makikallio K, et al. Low-dose aspirin does not improve ovarian responsiveness or pregnancy rate in IVF and ICSI patients: a randomized, placebo-controlled double-blind study. Hum Reprod 2005; 20: 2211-2214. [DOI:10.1093/humrep/dei020] [PMID]
3. Dirckx K, Cabri P, Merien A, Galajdova L, Gerris J, Dhont M, et al. Does low-dose aspirin improve pregnancy rate in IVF/ICSI? A randomized double-blind placebo controlled trial. Hum Reprod 2009; 24: 856-860. [DOI:10.1093/humrep/den476] [PMID]
4. Zaidi J, Pittrof R, Shaker A, Kyei-Mensah A, Campbell S, Tan SL. Assessment of uterine artery blood flow on the day of human chorionic gonadotropin administration by transvaginal color Doppler ultrasound in an in vitro fertilization program. Fertil Steril 1996; 65: 377-381. [DOI:10.1016/S0015-0282(16)58103-5]
5. Cacciatore B, Simberg N, Fusaro P, Tiitinen A. Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization-embryo transfer cycles. Fertil Steril 1996; 66: 130-134. [DOI:10.1016/S0015-0282(16)58400-3]
6. Chien LW, Au HK, Chen PL, Xiao J, Tzeng CR. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril 2002; 78: 245-251. [DOI:10.1016/S0015-0282(02)03223-5]
7. Ahrens KA, Silver RM, Mumford SL, Sjaarda LA, Perkins NJ, Wactawski-Wende J, et al. Complications and safety of preconception low-dose aspirin among women with prior pregnancy losses. Obstet Gynecol 2016; 127: 689-698. [DOI:10.1097/AOG.0000000000001301] [PMID] [PMCID]
8. Schisterman EF, Silver RM, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, et al. Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Lancet 2014; 384: 29-36. [DOI:10.1016/S0140-6736(14)60157-4]
9. Zhao M, Chang C, Liu Z, Chen LM, Chen Q. Treatment with low-dose aspirin increased the level LIF and integrin beta3 expression in mice during the implantation window. Placenta 2010; 31: 1101-1105. [DOI:10.1016/j.placenta.2010.10.002] [PMID]
10. Wang L, Huang X, Li X, Lv F, He X, Pan Y, et al. Efficacy evaluation of low-dose aspirin in IVF/ICSI patients evidence from 13 RCTs: A systematic review and meta-analysis. Medicine 2017; 96: e7720-e7726. [DOI:10.1097/MD.0000000000007720] [PMID] [PMCID]
11. Madani T, Ahmadi F, Jahangiri N, Bahmanabadi A, Bagheri Lankarani N. Does low-dose aspirin improve pregnancy rate in women undergoing frozen-thawed embryo transfer cycle? A pilot double-blind, randomized placebo-controlled trial. J Obstet Gynaecol Res 2019; 45: 156-163. [DOI:10.1111/jog.13802] [PMID]
12. Fatemi HM, Popovic-Todorovic B. Implantation in assisted reproduction: a look at endometrial receptivity. Reprod Biomed Online 2013; 27: 530-538. [DOI:10.1016/j.rbmo.2013.05.018] [PMID]
13. Haapsamo M, Martikainen H, Rasanen J. Low-dose aspirin and uterine haemodynamics on the day of embryo transfer in women undergoing IVF/ICSI: a randomized, placebo-controlled, double-blind study. Hum Reprod 2009; 24: 861-866. [DOI:10.1093/humrep/den489] [PMID]
14. Haapsamo M, Martikainen H, Rasanen J. Low-dose aspirin reduces uteroplacental vascular impedance in early and mid gestation in IVF and ICSI patients: a randomized, placebo-controlled double-blind study. Ultrasound Obstet Gynecol 2008; 32: 687-693. [DOI:10.1002/uog.6215] [PMID]
15. Khairy M, Banerjee K, El-Toukhy T, Coomarasamy A, Khalaf Y. Aspirin in women undergoing in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2007; 88: 822-831. [DOI:10.1016/j.fertnstert.2006.12.080] [PMID]
16. Siristatidis CS, Dodd SR, Drakeley AJ. Aspirin is not recommended for women undergoing IVF. Hum Reprod Update 2012; 18: 233. [DOI:10.1093/humupd/dmr049] [PMID]
17. Ruopp MD, Collins TC, Whitcomb BW, Schisterman EF. Evidence of absence or absence of evidence? A reanalysis of the effects of low-dose aspirin in in vitro fertilization. Fertil Steril 2008; 90: 71-76. [DOI:10.1016/j.fertnstert.2007.06.033] [PMID] [PMCID]
18. Duvan CI, Ozmen B, Satiroglu H, Atabekoglu CS, Berker B. Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study. J Assist Reprod Genet 2006; 23: 15-21. [DOI:10.1007/s10815-005-9003-3] [PMID] [PMCID]
19. Frattarelli JL, McWilliams GD, Hill MJ, Miller KA, Scott RT Jr. Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders. Fertil Steril 2008; 89: 1113-1117. [DOI:10.1016/j.fertnstert.2007.05.007] [PMID]
20. Imudia AN, Goldman RH, Awonuga AO, Wright DL, Styer AK, Toth TL. The impact of supraphysiologic serum estradiol levels on peri-implantation embryo development and early pregnancy outcome following in vitro fertilization cycles. J Assist Reprod Genet 2014; 31: 65-71. [DOI:10.1007/s10815-013-0117-8] [PMID] [PMCID]
21. Teh WT, McBain J, Rogers P. What is the contribution of embryo-endometrial asynchrony to implantation failure? J Assist Reprod Genet 2016; 33: 1419-1430. [DOI:10.1007/s10815-016-0773-6] [PMID] [PMCID]
22. Hsieh YY, Tsai HD, Chang CC, Lo HY, Chen CL. Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: a prospective, randomized study. J Assist Reprod Genet 2000; 17: 174-177. https://doi.org/10.1023/A:1009474307376 https://doi.org/10.1023/A:1009458215962 [DOI:10.1023/A:1009426303742]
23. Siristatidis CS, Basios G, Pergialiotis V, Vogiatzi P. Aspirin for in vitro fertilisation. Cochrane Database Syst Rev 2016; 11: CD004832. [DOI:10.1002/14651858.CD004832.pub4] [PMID] [PMCID]
24. Check JH, Dietterich C, Lurie D, Nazari A, Chuong J. A matched study to determine whether low-dose aspirin without heparin improves pregnancy rates following frozen embryo transfer and/or affects endometrial sonographic parameters. J Assist Reprod Genet 1998; 15: 579-582. [DOI:10.1023/A:1020373009043] [PMID] [PMCID]
25. Gelbaya TA, Kyrgiou M, Li TC, Stern C, Nardo LG. Low-dose aspirin for in vitro fertilization: a systematic review and meta-analysis. Hum Reprod Update 2007; 13: 357-364. [DOI:10.1093/humupd/dmm005] [PMID]
26. Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994; 9: 1954-1957. [DOI:10.1093/oxfordjournals.humrep.a138366] [PMID]
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