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Volume 8, Issue 2 (7-2010)
IJRM 2010, 8(2): 55-59 |
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Rezakhaniha B, Sirosbakht S. Efficacy of selective serotonin reuptake inhibitor (SSRI) in patient with premature ejaculation. IJRM 2010; 8 (2) :55-59
URL: http://ijrm.ir/article-1-180-en.html
URL: http://ijrm.ir/article-1-180-en.html
1- Department of Urology, Emam Reza Hospital, Tehran, Iran , Reza.bijan@yahoo.com
2- Faculty of Medicine, Army University of Medical Sciences (AJA), Tehran, Iran
2- Faculty of Medicine, Army University of Medical Sciences (AJA), Tehran, Iran
Abstract: (2384 Views)
Background: Premature ejaculation (PE) is the most common sexual dysfunction compliant in about 35-40% of men younger than 40 years; therefore a study for survey and diagnosis of this disorder is very important.
Objective: In this study the efficacy of 2 drugs (fluoxetine and citalopram) for treatment of patients suffering from PE is compared. We studied the effectiveness of both drugs in PE with different protocols to find out the most effective drug with least side effects.
Materials and Methods: In total 77 patients referred to the Urology Clinic of Emam Reza Hospital Tehran from 2006 to 2008 for the treatment of PE including 25 patients with anxiety disorder were randomly divided into 2 study groups. Patients belonging to first group (N= 43) received 40 mg (2 capsules of 20 mg) fluoxetine daily for 4 weeks and patients of the group II (N=34) received 40 mg citalopram daily for 4 weeks.
Results: The mean Intra Vaginal Ejaculation Latency Time (IVELT) before treatment in patients of group I was 58.26±41.83 seconds while after treatment it raised to 466.2±10.85 seconds. In group II the mean IVELT before treatment was 51.76±34.39 seconds while after treatment it elevated to 403.8±7.58 seconds.
Conclusion: Difference was significant in mean IVELT before and after treatment with fluoxetine and citalopram (each drug separately). In this study both drugs improved ejaculation duration while difference between 2 drugs was not significant (p>0.05)
Objective: In this study the efficacy of 2 drugs (fluoxetine and citalopram) for treatment of patients suffering from PE is compared. We studied the effectiveness of both drugs in PE with different protocols to find out the most effective drug with least side effects.
Materials and Methods: In total 77 patients referred to the Urology Clinic of Emam Reza Hospital Tehran from 2006 to 2008 for the treatment of PE including 25 patients with anxiety disorder were randomly divided into 2 study groups. Patients belonging to first group (N= 43) received 40 mg (2 capsules of 20 mg) fluoxetine daily for 4 weeks and patients of the group II (N=34) received 40 mg citalopram daily for 4 weeks.
Results: The mean Intra Vaginal Ejaculation Latency Time (IVELT) before treatment in patients of group I was 58.26±41.83 seconds while after treatment it raised to 466.2±10.85 seconds. In group II the mean IVELT before treatment was 51.76±34.39 seconds while after treatment it elevated to 403.8±7.58 seconds.
Conclusion: Difference was significant in mean IVELT before and after treatment with fluoxetine and citalopram (each drug separately). In this study both drugs improved ejaculation duration while difference between 2 drugs was not significant (p>0.05)
Type of Study: Original Article |
References
1. Rezakhaniha B, Safarinejad MA. A survey of prevalence of sexual disorders and risk factors in patient who Reffered in Urology ward in 501 Army Medical center 1383- 84, JAMA 2008; 4: 1041-1045.
2. Waldinger MD. Premature ejaculation: definition and drug treatment. Drugs 2007; 67: 547-568. [DOI:10.2165/00003495-200767040-00005]
3. Giuliano F, Clément P. Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 2006; 50: 454-566. [DOI:10.1016/j.eururo.2006.05.055]
4. Giuliano F, Hellstrom WJ. The pharmacological treatment of premature ejaculation. BJU Int 2008; 102: 668-675. [DOI:10.1111/j.1464-410X.2008.07719.x]
5. Shabsigh R, Rowland D. The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision as an appropriate diagnostic for premature ejaculation. J Sex Med 2007; 4: 1468-1478. [DOI:10.1111/j.1743-6109.2007.00557.x]
6. Waldinger MD. Recent advances in the classification, neurobiology and treatment of premature ejaculation. Adv Psychosom Med 2008; 29: 50-69. [DOI:10.1159/000126624]
7. Madeo B, Bettica P, Milleri S, Balestrieri A, Granata AR, Carani C, et al. The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study. J Sex Med 2008; 5: 2431-2441. [DOI:10.1111/j.1743-6109.2008.00843.x]
8. Hellstrom WJ. Emerging treatments for premature ejaculation: focus on dapoxetin. Neuropsychiatr Dis Treat 2009; 5: 32-46.
9. Safarinejad MR, Hosseini SY. Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study. Int J Impot Res 2006; 18:164-169. [DOI:10.1038/sj.ijir.3901384]
10. Rama Raju GA, Usha Rani P, Naidu MUR, Ramesh T, Schobha JC. Evaluation of fluoxetine in premature ejaculation. Indian Journal of Pharmacology 1997; 29: 204-205.
11. Montejo-González AL, Llorca G, Izquierdo JA, Ledesma A, Bouso-o M, Calcedo A, et al. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997; 23:176-194. [DOI:10.1080/00926239708403923]
12. Dinsmore WW, Hackett G, Goldmeier D, Waldinger M, Dean J, Wright P, et al. Topical eutectic mixture for premature ejaculation (TEMPE); A novel aerosol delivery from of lidocaine-prilocain for treating premature ejaculation. BJU int 2007; 99: 369-375. [DOI:10.1111/j.1464-410X.2006.06583.x]
13. Atmaca M, Kuioglu M. The efficacy of citalopram in the treatment of premature ejaculation; a placebo-control study. Int J Impot Res 2002; 14:502-505. [DOI:10.1038/sj.ijir.3900918]
14. Sterassberg D, Roland D, Colmipramine in the treatment of rapid premature ejaculation. J Sex Marital Ther 1999; 25:89-101. [DOI:10.1080/00926239908403982]
15. Porest H. Premature ejaculation. J Urologe A 2009; 48: 663,664.
16. McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, et al. An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008; 5: 1590-1606. [DOI:10.1111/j.1743-6109.2008.00901.x]
17. Clement P, Giuliano F. Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 2006; 50:454-466. [DOI:10.1016/j.eururo.2006.05.055]
18. Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 1998; 18: 274-281. [DOI:10.1097/00004714-199808000-00004]
19. Waldinger MD. Premature ejaculation: state of the art. Urol Clin North Am 2007; 34:591-599. [DOI:10.1016/j.ucl.2007.08.011]
20. Mattos RM, Marmo lucan A, Srougi M.Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Urol Int 2008; 80: 162-165. [DOI:10.1159/000112607]
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