Volume 19, Issue 4 (April 2021)                   Int J Reprod BioMed. 2021, 19(4): 333-338 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mary A P, Nandeesha H, Papa D, Chitra T, Ganesh R N, Menon V. Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study. Int J Reprod BioMed. 2021; 19 (4) :333-338
URL: http://ijrm.ir/article-1-1803-en.html
Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study
Ann Prasad Mary1 , Hanumanthappa Nandeesha *2 , Dasari Papa3 , Thiagaraju Chitra3 , Rajesh Nachiappa Ganesh4 , Vikas Menon5
1- Biochemistry Department, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India., Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantrinagar, Dindivanam St., Puducherry, India. Postal code: 605006
2- Biochemistry Department, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India. , nandijipmer@gmail.com
3- Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India., Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantrinagar, Dindivanam St., Puducherry, India. Postal code: 605006
4- Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India., Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantrinagar, Dindivanam St., Puducherry, India. Postal code: 605006
5- Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India., Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantrinagar, Dindivanam St., Puducherry, India. Postal code: 605006
Abstract:   (2673 Views)
Background: Matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17) and psychological stress are known to play a role in the pathogenesis of male infertility.
Objective: To assess the association of MMP-9 with IL-17 and psychological stress in infertile men.
Materials and Methods: In this cross-sectional study, 39 men with infertility diagnosed based on semen analysis and 39 subjects with normal semen analysis were included in the study. MMP-9 and IL-17 were estimated in both groups by ELISA. Perceived stress scale was used to assess psychological stress in controls and cases.
Results: In infertile cases, MMP-9and IL-17 were significantly increased when compared with controls (p = 0.046, p = 0.041 respectively). A significant association of MMP-9 was observed with IL-17 (r = 0.335, p = 0.037) and perceived stress scale (r = 0.329, p = 0.041).
Conclusion: IL-17 and stress increase MMP- 9 levels in infertile men.
 
Keywords: Infertility, Interleukins, Peptide hydrolase.
Full-Text [PDF 274 kb]   (1770 Downloads) |   |   Full-Text (HTML)  (549 Views)  
Type of Study: Original Article | Subject: Reproductive Andrology
* Corresponding Author Address: Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantrinagar, Dindivanam St., Puducherry, India. Postal code: 605006
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb