Volume 19, Issue 8 (August 2021)                   IJRM 2021, 19(8): 681-688 | Back to browse issues page


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Jafari H, Mirzaei Najmabadi K, Latifnejad Roudsari R, Rakhshkhorshid M. The factors affecting male infertility: A systematic review. IJRM 2021; 19 (8) :681-688
URL: http://ijrm.ir/article-1-1889-en.html
1- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Nursing and Midwifery Care Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. , jafari.hamideh@yahoo.com
3- Nursing and Midwifery Care Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Department of Midwifery, Nursing and Midwifery School, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract:   (2400 Views)
Background: In recent years, the incidence of male infertility has increased worldwide. It is necessary to study the factors that influence male infertility in each area/region for better management.
Objective: To determine the factors affecting male infertility in the Iranian male population.
Materials and Methods: An online search was conducted in electronic databases including PubMed, Google Scholar, SID, and Scopus to identify articles on the factors associated with male infertility, published in English and Persian. The keywords used to perform the search included "factor", "epidemiology", "causes of infertility", and "male infertility. The search was conducted without a time restriction, up to April 2020.
Results: The search resulted in a total number of 691 studies. After an assessment of the articles, finally 14 studies were included in this study with a total number of 26,324 infertile males. The factors associated with male infertility included semen abnormalities, varicocele and testis disorder, smoking, exposure to heat, obesity, anabolic steroids, vascular abnormalities, anti-spermatogenesis factors, antidepressants, taking ranitidine and cimetidine, penile discharge and genital ulcers, painful micturition, occupational factors, alcohol, chronic disease, sexual disorder, Surgical and urological diseases, genetic factors and herpes infection. Among these, the semen and varicocele disorders were common in most studies.
Conclusion: The present review suggests that the factors affecting male infertility in Iran are similar to those reported from other countries. The results of this study can be used in adopting appropriate strategies for infertility management in Iran.
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Type of Study: Review Article | Subject: Fertility & Infertility

References
1. Latifnejad Roudsari R, Jafari H, Taghipour A, Khadem N, Ebrahimzdeh S. The association of religious beliefs in infertile couples' attitude towards donation procedures and its selection as a therapeutic approach to infertility. Iran J Obstet Gynecol Infertil 2013; 16: 1-10.
2. Latifnejad Roudsari R, Jafari H, Taghipour A. The relationship of sociocultural beliefs andinfertile couples' attitude toward reproductivedonation: A descriptive-correlational study. Int J Reprod BioMed 2018; 17: 315-324. [DOI:10.18502/ijrm.v17i5.4599] [PMID] [PMCID]
3. Gill K, Jakubik J, Kups M, Rosiak-Gill A, Kurzawa R, Kurpisz M, et al. The impact of sedentary work on sperm nuclear DNA integrity. Folia Histochem Cytobiol 2019; 57: 15-22.
4. Hadizadeh-Talasaz F, Simbar M, Latifnejad Roudsari R. Exploring infertile couples' decisions to disclose donor conception to the future child. Int J Fertil Steril 2020; 14: 240-246.
5. Direkvand Moghaddam A, Delpisheh A, Sayehmiri K. An investigation of the worldwide prevalence of infertility as a systematic review. Qom Univ Med Sci J 2016; 10: 76-87.
6. Kazemijaliseh H, Tehrani FR, Behboudi-Gandevani S, Hosseinpanah F, Khalili D, Azizi F. The prevalence and causes of primary infertility in Iran: A population-based study. Glob J Health Sci 2015; 7: 226-232. [DOI:10.5539/gjhs.v7n6p226] [PMID] [PMCID]
7. Schuppe HC, Pilatz A, Hossain H, Diemer T, Wagenlehner F, Weidner W. Urogenital infection as a risk factor for male infertility. Deutsches Arzteblatt Int 2017; 114: 339-346. [DOI:10.3238/arztebl.2017.0339] [PMID] [PMCID]
8. Jafari H, Latifnejad Roudsari R, Taghipour A, Khadem Ghaebi N, Ebrahim Zadeh S. Comparison of knowledge and attitude towards reproductive donation procedures between recipient and non-recipient infertile couples at Mashhad Infertility Center. J Torbat Heydariyeh Univ Med Sci 2015; 3: 16-25.
9. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrin 2015; 13: 1-9. [DOI:10.1186/s12958-015-0032-1] [PMID] [PMCID]
10. Bundhun PK, Janoo G, Bhurtu A, Teeluck AR, Soogund MZS, Pursun M, et al. Tobacco smoking and semen quality in infertile males: A systematic review and meta-analysis. BMC Public Health 2019; 19: 1-11. [DOI:10.1186/s12889-018-6319-3] [PMID] [PMCID]
11. Macaluso M, Wright-Schnapp TJ, Chandra A, Johnson R, Satterwhite CL, Pulver A, et al. A public health focus on infertility prevention, detection, and management. Fertil Steril 2010; 93: 1-10. [DOI:10.1016/j.fertnstert.2008.09.046] [PMID]
12. Masoumi SZ, Parsa P, Darvish N, Mokhtari S, Yavangi M, Roshanaei G. An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan. Iran J Reprod Med 2015; 13: 513-516.
13. Ombelet W. Global access to infertility care in developing countries: A case of human rights, equity and social justice. Facts Views Vis Obgyn 2011; 3: 257-266.
14. Taghipour A, Latifnejad Roudsari R. The association of socio-demographic characteristics of infertile men and women with their attitude towards donation procedures. Journal of Torbat Heydariyeh University of Medical Sciences 2019; 7: 65-76.
15. Critical appraisal tools 2018. Available at: https://jbi.global/critical-appraisal-tools.
16. Ahmadi MRH, Yasemi M, Peyman H, Hemati K, Khajavikhan J, Yaghoubi M, et al. Associated factors with male infertility: A case control study. J Clin Diagn Res 2014; 8: 11-13.
17. Safarinejad MR. Infertility among couples in a population-based study in Iran: Prevalence and associated risk factors. Int J Androl 2008; 31: 303-314. [DOI:10.1111/j.1365-2605.2007.00764.x] [PMID]
18. Kamali M, Baghestani AR, Kashfi F, Kashani H, Tavajohi S, Amir Chaghmaghi E. A survey on infertility in Royan Institute. Iran J Fertil Steril 2007; 1: 23-26.
19. Karimpur Malekshah A, Moghaddam AE, Moslemizadeh N, Peivandi S, Barzegarnejad A, Musanejad N, et al. Infertility in Mazandaran province-north of Iran: An etiological study. Iran J Reprod Med 2011; 9: 21-24.
20. Taghavi R, Tavakkoli Tabassi K, Mohammadi Sh, Kor K. Epidemiologic study 2000 infertile males in urology clinic of Imam Reza Hospital of Mashhad. J Zabol Univ Med Sci 2011; 3: 11-16.
21. Choobineh H, Sadighi Gilani M, Hassanzadeh G, Saeepour N, Habibi M, Falahi P, et al. Assessment of socio-demographic characteristics of infertile men who referred to Shariati Hospital, Tehran, Iran. Iran J Obstet Gynecol Infertil 2013; 16: 6-12.
22. Keshavarzi F, Borna MHO, Bakhtiari F. [The survey of infertility risk factors in admitted men to infertility center of Mo'tazedi hospital in Kermanshah, 2012-2013]. J Clin Res Paramed Sci 2016; 5: 78-85. (in Persian)
23. Mahboubi M, Foroughi F, Ghahramani F, Shahandeh H, Moradi S, Shirzadian T. A case-control study of the factors affecting male infertility. Turkish J Med Sci 2014; 44: 862-865. [DOI:10.3906/sag-1304-35] [PMID]
24. Hashemzadeh M, Tagizadeh Z, Behboodi Mogadam Z, Montazeri A, Rashidi B, Shams M, et al. Relationship between obesity and sperm parameters in men with idiopathic infertility. Iran J Obstet Gynecol Infertil 2018; 21: 35-41.
25. Sohrabvand F, Jafari M, Shariat M, Haghollahi F, Lotfi M. Frequency and epidemiologic aspects of male infertility. Acta Medica Iranica 2015; 53: 231-235.
26. Karimpur Malekshah A, Joursaraii GA, Mousanejad N, Mir MRA, Moghaddam AE. [The frequency of varicoceles in men with primary and secondary infertility referring to two infertility centers in Mazandaran during 2001-2005]. Feyz 2006; 10: 50-54. (in Persian)
27. Shafabakhsh M, Sadeghian HA, Ehramposh MH, Aflatoonian A, Dehghani A, Ghaneian MT. [The relationship of smoking, alcohol, and drugs consumption on the quality of semen parameters in males referring to the infertility center of Yazd in 2016]. Tolooebehdasht 2019; 17: 44-54. (in Persian)
28. Monavari SH, Vaziri MS, Khalili M, Shamsi-Shahrabadi M, Keyvani H, Mollaei H, et al. Asymptomatic seminal infection of herpes simplex virus: Impact on male infertility. J Biomed Res 2013; 27: 56-61.
29. Jarow JP. Effects of varicocele on male fertility. Hum Reprod Update 2001; 7: 59-64. [DOI:10.1093/humupd/7.1.59] [PMID]
30. Aubuchon M, Burney RO, Schust DJ, Yao MW. Infertility and assisted reproductive technology. Berek & Novak's Gynecology Fifteenth ed: Lippincott Williams & Wilkins, a Wolters KLuwer business. 2012.
31. Li Y, Lin H, Li Y, Cao J. Association between socio-psycho-behavioral factors and male semen quality: Systematic review and meta-analyses. Fertil Steril 2011; 95: 116-123. [DOI:10.1016/j.fertnstert.2010.06.031] [PMID]
32. Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, et al. Male reproductive disorders and fertility trends: Influences of environment and genetic susceptibility. Physiol Rev 2015; 96: 55-97. [DOI:10.1152/physrev.00017.2015] [PMID] [PMCID]
33. Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R, et al. Causes of male infertility: A 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod 2016; 32: 18-31. [DOI:10.1093/humrep/dew284] [PMID] [PMCID]
34. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, et al. European association of urology guidelines on male infertility: The 2012 update. Eur Urol 2012; 62: 324-332. [DOI:10.1016/j.eururo.2012.04.048] [PMID]
35. Junqing W, Ersheng G, Qiuying Y. The investigation on working and other lifestyles influencing semen quality of Chinese young men. Chinese J Fam Plan 2004; 12: 346-349.
36. Durairajanayagam D. Lifestyle causes of male infertility. Arab J Urol 2018; 16: 10-20. [DOI:10.1016/j.aju.2017.12.004] [PMID] [PMCID]
37. Yao DF, Mills JN. Male infertility: Lifestyle factors and holistic, complementary, and alternative therapies. Asian J Androl 2016; 18: 410-418. [DOI:10.4103/1008-682X.175779] [PMID] [PMCID]
38. Lotti F, Corona G, Vitale P, Maseroli E, Rossi M, Fino M, et al. Current smoking is associated with lower seminal vesicles and ejaculate volume, despite higher testosterone levels, in male subjects of infertile couples. Hum Reprod 2015; 30: 590-602. [DOI:10.1093/humrep/deu347] [PMID]
39. Ricci E, Al Beitawi S, Cipriani S, Candiani M, Chiaffarino F, Viganò P, et al. Semen quality and alcohol intake: A systematic review and meta-analysis. Reprod Biomed 2017; 34: 38-47. [DOI:10.1016/j.rbmo.2016.09.012] [PMID]
40. Tsao CW, Liu CY, Chou YC, Cha TL, Chen SC, Hsu CY. Exploration of the association between obesity and semen quality in a 7630 male population. PLoS One 2015; 10: 1-13. [DOI:10.1371/journal.pone.0119458] [PMID] [PMCID]
41. Dechanet C, Belaisch-Allart J, Hedon B. [Prognosis criteria for the management of the infertile couple]. J Gynecol Obstet Biol Reprod 2010; 39: 9-26. (in French). [DOI:10.1016/S0368-2315(10)70027-2]
42. Daumler D, Chan P, Lo KC, Takefman J, Zelkowitz P. Men's knowledge of their own fertility: A population-based survey examining the awareness of factors that are associated with male infertility. Hum Reprod 2016; 31: 2781-2790. [DOI:10.1093/humrep/dew265] [PMID] [PMCID]
43. Sharma R, Harlev A, Agarwal A, Esteves SC. Cigarette smoking and semen quality: A new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Eur Urol 2016; 70: 635-645. [DOI:10.1016/j.eururo.2016.04.010] [PMID]
44. Davar R, Sekhavat L, Naserzadeh N. Semen parameters of non-infertile smoker and non-smoker men. J Med Life 2012; 5: 465-468.
45. Lingappa HA, Govindashetty AM, Puttaveerachary AK, Manchaiah S, Krishnamurthy A, Bashir S, et al. Evaluation of effect of cigarette smoking on vital seminal parameters which influence fertility. J Clin Diag Res 2015; 9: 13-15. [DOI:10.7860/JCDR/2015/13295.6227] [PMID] [PMCID]
46. Elshal MF, El-Sayed IH, Elsaied MA, El-Masry SA, Kumosani TA. Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: Association with cigarette smoking. Clin Biochem 2009; 42: 589-594. [DOI:10.1016/j.clinbiochem.2008.11.012] [PMID]
47. Zenzes MT. Smoking and reproduction: Gene damage to human gametes and embryos. Hum Reprod Update 2000; 6: 122-131. [DOI:10.1093/humupd/6.2.122] [PMID]
48. Schagdarsurengin U, Western P, Steger K, Meinhardt A. Developmental origins of male subfertility: Role of infection, inflammation, and environmental factors. Seminars in Immunopath 2016; 38: 765-781. [DOI:10.1007/s00281-016-0576-y] [PMID]
49. Zeinab H, Zohreh S, Gelehkolaee KS. Lifestyle and outcomes of assisted reproductive techniques: A narrative review. Glob J Health Sci 2015; 7: 11-22. [DOI:10.5539/gjhs.v7n5p11] [PMID] [PMCID]
50. Joffe M. What has happened to human fertility? Hum Reprod 2009; 25: 295-307. [DOI:10.1093/humrep/dep390] [PMID]
51. Povey A, Stocks S. Epidemiology and trends in male subfertility. Hum Fertil 2010; 13: 182-188. [DOI:10.3109/14647273.2010.515700] [PMID]
52. Ghanei M, Rajaee M, Khateri S, Alaeddini F, Haines D. Assessment of fertility among mustard-exposed residents of Sardasht, Iran: A historical cohort study. Reprod Toxicol 2004; 18: 635-639. [DOI:10.1016/j.reprotox.2004.03.003] [PMID]
53. Boggia B, Carbone U, Farinaro E, Zarrilli S, Lombardi G, Colao A, et al. Effects of working posture and exposure to traffic pollutants on sperm quality. J Endocrin Invest 2009; 32: 430-434. [DOI:10.1007/BF03346481] [PMID]
54. Figà‐Talamanca I, Cini C, Varricchio G, Dondero F, Gandini L, Lenzi A, et al. Effects of prolonged autovehicle driving on male reproductive function: A study among taxi drivers. American J of Indust Med 1996; 30: 750-758. https://doi.org/10.1002/(SICI)1097-0274(199612)30:6<750::AID-AJIM12>3.0.CO;2-1 [DOI:10.1002/(SICI)1097-0274(199612)30:63.0.CO;2-1]
55. Støy J, Hjøllund NHI, Mortensen JT, Burr H, Bonde JP. Semen quality and sedentary work position. Int J Andr 2004; 27: 5-11. [DOI:10.1046/j.0105-6263.2003.00428.x] [PMID]
56. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th Ed. Switzerland: World Health Organization Press; 2010.
57. Jensen TK, Jacobsen R, Christensen K, Nielsen NC, Bostofte E. Good semen quality and life expectancy: A cohort study of 43,277 men. Am J Epidemiol 2009; 170: 559-565. [DOI:10.1093/aje/kwp168] [PMID]
58. Eisenberg ML, Li S, Behr B, Cullen MR, Galusha D, Lamb DJ, et al. Semen quality, infertility and mortality in the USA. Hum Reprod 2014; 29: 1567-1574. [DOI:10.1093/humrep/deu106] [PMID] [PMCID]
59. Parsanezhad M, Jahromi B, Zare N, Keramati P, Khalili A, Parsa-Nezhad M. Epidemiology and etiology of infertility in Iran, systematic review and meta-analysis. J Womens Health, Issues Care 2013; 2: 2-6. [DOI:10.4172/2325-9795.1000121]

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