International Journal of
Reproductive Biomedicine
Sat, Dec 21, 2024
[Archive]
Volume 18, Issue 7 (July 2020)
IJRM 2020, 18(7): 509-516 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Parsa E, Hoseini S M, Namayandeh S M, Akhavansales Z, Sheikhha M H. Investigating the rate of different ovarian response in in vitro fertilization cycles based on estrogen receptor beta +1730 polymorphism: A cross-sectional study. IJRM 2020; 18 (7) :509-516
URL: http://ijrm.ir/article-1-1956-en.html
URL: http://ijrm.ir/article-1-1956-en.html
Elham Parsa * 
1, Seyed Mehdi Hoseini2 , Seyedeh Mahdieh Namayandeh3 , Zhima Akhavansales2 , Mohammad Hasan Sheikhha4
1, Seyed Mehdi Hoseini2 , Seyedeh Mahdieh Namayandeh3 , Zhima Akhavansales2 , Mohammad Hasan Sheikhha4
1- Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
2- Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Afshar Research and Development Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Afshar Research and Development Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (2187 Views)
Background: The response to ovarian stimulation is different among women referring for assisted reproductive techniques. This difference could be due to different genotypes in genes related to reproduction such as estrogen receptor beta (ERβ or ESR2) gene.
Objective: In the present study, we explored the rate of ESR2 gene polymorphism in infertile women undergoing IVF treatment with different ovarian response to ovulation induction.
Materials and Methods: A cross-sectional study was performed among 91 infertile women. The relationship between genotype distribution of the +1730 G/A polymorphism in the ESR2 gene (rs4986938) and the mean number of follicles and oocytes, their mean ratio, mean number of embryos, mean size of the follicles and pregnancy rates were measured. The ESR2 gene +1730 G/A polymorphism were identified by the amplification-refractory mutation system-polymerase chain reaction.
Results: Genotypes GG, GA, and AA of the ESR2 gene presented frequencies of 27.5%, 67%, and 5.5%, respectively, in the infertile women. The results of the study showed that the mean number of follicles and oocytes, their mean ratio, mean number of embryos, mean size of the follicles, and pregnancy rates are not related to different genotypes.
Conclusion: According to the endocrine and paracrine factors which are involved in the ovulation induction and maturation of oocytes, more studies with higher number of participants are required to confirm the results of the present study; in addition, further studies are required to find out other gene polymorphisms affecting estrogen receptor efficacy in the infertile women.
Objective: In the present study, we explored the rate of ESR2 gene polymorphism in infertile women undergoing IVF treatment with different ovarian response to ovulation induction.
Materials and Methods: A cross-sectional study was performed among 91 infertile women. The relationship between genotype distribution of the +1730 G/A polymorphism in the ESR2 gene (rs4986938) and the mean number of follicles and oocytes, their mean ratio, mean number of embryos, mean size of the follicles and pregnancy rates were measured. The ESR2 gene +1730 G/A polymorphism were identified by the amplification-refractory mutation system-polymerase chain reaction.
Results: Genotypes GG, GA, and AA of the ESR2 gene presented frequencies of 27.5%, 67%, and 5.5%, respectively, in the infertile women. The results of the study showed that the mean number of follicles and oocytes, their mean ratio, mean number of embryos, mean size of the follicles, and pregnancy rates are not related to different genotypes.
Conclusion: According to the endocrine and paracrine factors which are involved in the ovulation induction and maturation of oocytes, more studies with higher number of participants are required to confirm the results of the present study; in addition, further studies are required to find out other gene polymorphisms affecting estrogen receptor efficacy in the infertile women.
Type of Study: Original Article |
References
1. Direkvand-Moghadam A, Sayehmiri K, Delpisheh A, Direkvand-Moghadam A. The global trend of infertility: an original review and meta-analysis. Int J Epidemiol Res 2014; 1: 35-43.
2. Parsanezhad ME, Namavar Jahromi B, Zare N, Keramati P, Khalili A, Parsa-Nezhad M. Epidemiology and Etiology of Infertility in Iran, Systematic Review and Meta-Analysis. J Womens Health 2013; 2: 1000121-1000126. [DOI:10.4172/2325-9795.1000121]
3. A.Al-Turki H. Prevalence of primary and secondary infertility from tertiary center in eastern Saudi Arabia. Middle East Fertil Soc J 2015; 20: 237-240. [DOI:10.1016/j.mefs.2015.02.001]
4. Adenike OB, Wasiu A, Sunday O, Olaniyan B, Olufemi O. Prevalence of Infertility and Acceptability of Assisted Reproductive Technology among Women Attending Gynecology Clinics in Tertiary Institutions in Southwestern Nigeria. Gynecol Obstet 2014; 4: 1-7.
5. Aflatoonian A, Seyedhassani SM, Tabibnejad N. The epidemiological and etiological aspects of infertility in Yazd province of Iran. Iran J Reprod Med 2009; 7: 117-122.
6. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J. Estimating the prevalence of infertility in Canada. Hum Reprod 2012; 27: 738-746. [DOI:10.1093/humrep/der465] [PMID] [PMCID]
7. Mascarenhas NM, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: A systematic analysis of 277 health surveys. PLOS Med 2012; 9: e1001356. [DOI:10.1371/journal.pmed.1001356] [PMID] [PMCID]
8. Vahidi S, Ardalan A, Mohammad K. Prevalence of primary infertility in the Islamic Republic of Iran in 2004-2005. Asia Pac J Public Health 2009; 21: 287-293. [DOI:10.1177/1010539509336009] [PMID]
9. Shah K, Sivapalan G, Gibbons N, Tempest H, Griffin KD. The genetic basis of infertility. Reproduction 2003; 126: 13-25. [DOI:10.1530/rep.0.1260013] [PMID]
10. Meldrum DR. Female reproductive aging ovarian and uterine factors. Fertil Sterli 1993; 59: 1-5. [DOI:10.1016/S0015-0282(16)55608-8]
11. Guo R, Zheng N, Ding S, Zheng Y, Feng L. Associations between estrogen receptor-beta polymorphisms and endometriosis risk:a meta-analysis. Diagn Pathol 2014; 9: 184. [DOI:10.1186/s13000-014-0184-x] [PMID] [PMCID]
12. Lee HR, Kim TH, Choi KC. Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse. Lab Anim Res 2012; 28: 71-76. [DOI:10.5625/lar.2012.28.2.71] [PMID] [PMCID]
13. Nott SL, Huang Y, Fluharty BR, Sokolov AM, Huang M, Cox C, et al. Do estrogen receptor β polymorphisms play a role in the pharmacogenetics of estrogen signaling? Curr Pharmacogenomics Person Med 2008; 6: 239-259. [DOI:10.2174/187569208786733820] [PMID] [PMCID]
14. Zulli K, Bianco B, Mafra AF, Teles JS, Christofolini DM, Barbosa CP. Polymorphism of the estrogen receptor b gene is related to infertility and infertility associated endometriosis. Arq Bras Endocrinol Metab 2010; 54: 567-571. [DOI:10.1590/S0004-27302010000600010] [PMID]
15. Seleem AK, Abdel Aziz AA, EL. Sayd EH, el Dahtory F, Basha EA. The progins progesterone receptor gene polymorphism and polymorphism of the estrogen receptor β gene in endometriosis. IOSR J Pharm Biol Sci 2014; 9: 16-22. [DOI:10.9790/3008-09311622]
16. Sundermann EE, Maki MP, Bishop RJ. A review of estrogen receptor α gene (ESR1) polymorphisms, mood, and cognition. Menopause 2010; 17: 874-886. [DOI:10.1097/gme.0b013e3181df4a19] [PMID] [PMCID]
17. Pettersson K, Gustafsson JA. Role of estrogen receptor beta in estrogen action. Ann Rev Physiol 2001; 63: 165-192. [DOI:10.1146/annurev.physiol.63.1.165] [PMID]
18. Drummond AE, Fuller PJ. The importance of ERb signalling in the ovary. J Endocrinol 2010; 205: 15-23. [DOI:10.1677/JOE-09-0379] [PMID]
19. Kim JJ, Choi YM, Choung SH, Yoon SH, Lee GH, Moon SY. Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome. Fertil Steril 2010; 93: 1942-1947. [DOI:10.1016/j.fertnstert.2008.12.040] [PMID]
20. de Mattos CS, Trevisan CM, Peluso C, Adami F, Cordts EB, Christofolini DM, et al. ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women. J Ovarian Res 2014; 7: 114. [DOI:10.1186/s13048-014-0114-2] [PMID] [PMCID]
21. Bianco B, Christofolini DM, Mafra FA, Brandes A, Zulli K, Barbosa CP. +1730 G/A polymorphism of the estrogen receptor b gene (ERb) may be an important genetic factor predisposing to endometriosis. Acta Obstet Gynecol Scand 2009; 88: 1397-1401. [DOI:10.3109/00016340903297168] [PMID]
22. Boudjenah R, Molina-Gomes D, Torre A, Bergere M, Baill M, Boitrelle F, et al. Genetic polymorphisms influence the ovarian response to rFSH stimulation in patients undergoing in vitro fertilization programs with ICSI. PLoS One 2012; 7: e38700. [DOI:10.1371/journal.pone.0038700] [PMID] [PMCID]
23. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, et al. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA 1998; 95: 15677-15682. [DOI:10.1073/pnas.95.26.15677] [PMID] [PMCID]
24. Sheikhha MH, Kalantar SM, Aflatoonian A. [The relationship between estrogen receptor alpha gene polymorphism and ovarian response to ovulation induction in women under IVF treatment.] Med J Reprod Infertil 2007; 7: 315-323. (in Persian)
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
