Volume 8, Issue 4 (7-2010)                   IJRM 2010, 8(4): 153-156 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Soltanghoraee H, Arefi S, Mohammadzadeh A, Taheri A, Zeraati H, Hashemi S B et al . Thyroid autoantibodies in euthyroid women with recurrent abortions and infertility. IJRM 2010; 8 (4) :153-156
URL: http://ijrm.ir/article-1-197-en.html
Abstract:   (1910 Views)
Background: Evidences suggest an association between the prevalence of thyroid peroxidase (anti-TPO) and anti thyroglobulin (anti-Tg) with recurrent abortions and infertility. Iodine deficiency was once endemic in Iran and little data is available about the prevalence of these antibodies in different groups of fertile or infertile individuals.
Objective: This case control study was designed to compare the presence of anti-TPO and anti-Tg in four groups of women to reveal their role in the etiology of recurrent abortion and infertility.
Materials and Methods: Four groups of euthyroid women referring to Avicenna Infertility Clinic in Tehran were selected; 95 cases as fertile controls and 70, 78 and 137 cases with male and female factor infertility and recurrent abortion respectively. TSH, anti-TPO and anti-Tg were evaluated by chemiluminescent immunoassay.
Results: The prevalence of the above mentioned autoantibodies in euthyroid controls was about 25% and the percentage of people with an anti-Tg >500 was two times bigger in the abortion group compared to the control group (p<0.05) and the proportion of people with an anti-Tg >500 in younger cases in the abortion group was significantly higher than the rest of the cases (p<0.05). Anti-TPO distribution had no significant differences. Conclusion: There were no statistically significant differences among four groups. It seems that more comprehensive studies are needed to reach a common conclusion about thyroid autoantibodies in women with recurrent abortions in different groups and different parts of Iran. In addition, dividing the recurrent abortion and infertility groups on the basis of their etiologies could be effective.
Full-Text [PDF 108 kb]   (399 Downloads) |   |   Full-Text (HTML)  (237 Views)  
Type of Study: Original Article |

References
1. Fox-Lee L, Schust D. Recurrent Pregnancy Loss. In: Berek JS. Berek and Novak's Gynecology. Philadelphia: Lippincott Williams & Wilkins; 2007; 1277-1282.
2. Matalon ST, Blank M, Ornoy A, Shoenfeld Y. The association between anti-thyroid antibodies and pregnancy loss. Am J Reprod Immunol 2001; 45:72-77. [DOI:10.1111/j.8755-8920.2001.450202.x]
3. Putowski L, Darmochwal-Kolarz D, Rolinski J, Oleszczuk J, Jakowicki J. The immunological profile of infertile women after repeated IVF failure (Preliminary study). Eur J Obstet Gynecol Reprod Biol 2004; 112: 192-196. [DOI:10.1016/j.ejogrb.2003.06.012]
4. Choudhury SR, Knapp LA. Human reproductive failure I: immunological factors. Hum Reprod Update 2001; 7: 113-134. [DOI:10.1093/humupd/7.2.113]
5. Stagnaro-Green A, Glinoer D. Thyroid autoimmunity and the risk of miscarriage. Best Pract Res Clin Endocrinol Metab 2004; 18: 167-181. [DOI:10.1016/j.beem.2004.03.007]
6. Kaprara A, Krassas GE. Thyroid autoimmunity and miscarriage. Hormones 2008; 7: 294-302. [DOI:10.14310/horm.2002.1210]
7. Heydarian P, Ordookhani A, Azizi F. Goiter rate, serum thyrotropin, thyroid autoantibodies and urinary iodine concentration in Tehranian adults before and after national salt iodization. J Endocrinol Invest 2007; 30: 404-410. [DOI:10.1007/BF03346318]
8. Azizi F, Hedayati M, Rahmani M, Sheikholeslam R, Allahverdian S, Salarkia N. Reappraisal of the risk of iodine-induced hyperthyroidism: an epidemiological population survey. J Endocrinol Invest 2005; 28: 23-29. [DOI:10.1007/BF03345525]
9. Li TC, Makris M, Tomsu M, Tuckerman E, Laird S. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update 2002; 8: 463-481. [DOI:10.1093/humupd/8.5.463]
10. Reznikoff-Etievant MF, Cayol V, Zou GM, Abuaf N, Robert A, Johanet C, et al. Habitual abortions in 678 healthy patients: investigation and prevention. Hum Reprod 1999; 14: 2106-2109. [DOI:10.1093/humrep/14.8.2106]
11. Marai I, Carp H, Shai S, Shabo R, Fishman G, Shoenfeld Y. Autoantibody panel screening in recurrent miscarriages. Am J Reprod Immunol 2004; 51: 235-240. [DOI:10.1111/j.1600-0897.2004.00153.x]
12. Khaleeli A. Prevalence of thyroid antibodies in Shiraz, Iran, an area with iodine deficiency. Postgrad Med J 1981; 57: 23-27. [DOI:10.1136/pgmj.57.663.23]
13. Stirrat GM. Recurrent miscarriage II: clinical associations, causes, and management. Lancet 1990; 336: 728-733. [DOI:10.1016/0140-6736(90)92215-4]
14. Aminorroaya A, Momenzadeh M, Hovsepian S, Haghighi S, Amini M. Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area. East Mediterr Health J 2008; 14: 325-332.
15. Zois C, Stavrou I, Kalogera C, Svarna E, Dimoliatis I, Seferiadis K, et al. High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece. Thyroid 2003; 13: 48548-48549. [DOI:10.1089/105072503322021151]
16. Liu N, Zuo A, Liang D, Zhang Z, Guo G, Chai Z. Effect of iodine supplement on iodine status and 5'-deiodinase activity in the brain of neonatal rats with iodine deficiency. Biol Trace Elem Res 2006; 114: 207-215. [DOI:10.1385/BTER:114:1:207]
17. Sarvghadi F, Hedayati M, Mehrabi Y, Azizi F. Follow up of patients with postpartum thyroiditis: a population-based study. Endocrine 2005; 27: 279-282. [DOI:10.1385/ENDO:27:3:279]
18. Shahbazian HB, Sarvghadi F, Azizi F. Prevalence and characteristics of postpartum thyroid dysfunction in Tehran. Eur J Endocrinol 2001; 145:397-401. [DOI:10.1530/eje.0.1450397]

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb