Volume 19, Issue 8 (August 2021)                   IJRM 2021, 19(8): 733-740 | Back to browse issues page

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Kashani L, Moini A, Esfidani T, Yamini N, Mohiti S. Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate -to -severe endometriosis: An RCT. IJRM 2021; 19 (8) :733-740
URL: http://ijrm.ir/article-1-1992-en.html
Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate -to -severe endometriosis: An RCT
Ladan Kashani1 , Ashraf Moini1 , Tayebeh Esfidani1 , Nazila Yamini1 , Shima Mohiti * 2
1- Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Obstetrics and Gynecology, Arash Womens’ Hospital, Tehran University of Medical Sciences, Tehran, Iran. , shimamohiti56@gmail.com
Abstract:   (1421 Views)
Background: Nearly 25-50% of infertile women have endometriosis. There are reports of disorders in the expression of granulocyte colony-stimulating factor (G-CSF) receptors in women with endometriosis.
Objective: To examine the effect of intrauterine administration of G-CSF in in vitro fertilization (IVF) cycles on the fertility rate of infertile women with moderate-to-severe endometriosis.
Materials and Methods: This clinical trial was conducted on 66 infertile women with moderate-to-severe endometriosis, undergoing IVF and intracytoplasmic sperm injection (ICSI). The participants were allocated into two groups via simple randomization: the G-CSF (n = 27) and control (n = 39) groups. In the G-CSF intervention group, on the oocyte pick-up day, immediately after an ovarian puncture, 300 μg of G-CSF was injected through a transcervical catheter under abdominal ultrasound guide to visualize flushing into the uterine cavity. Women in the control group received no intervention. The two groups were evaluated for clinical pregnancy.
Results: No significant difference was noted in the demographic characteristics of the two groups. The rate of clinical pregnancy was 28.2% in the control group and 25.9% in the G-CSF group, indicating no significant difference (p = 0.83).
Conclusion: The results showed that the intrauterine injection of G-CSF had no effects on pregnancy in women with stage-3/4 endometriosis undergoing IVF.
Keywords: G-CSF, In vitro fertilization, Endometriosis, Pregnancy
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Type of Study: Original Article | Subject: Assisted Reproductive Technologies
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