چگونه سرب منجر به ناباروری مردان می شود؟

ویژه, محسن; اسمیت, درک- آر; هو, پلینگ چی

دوره 9، شماره 1 - ( 4-1390 ) جلد 9 شماره 1 صفحات 0-0 | برگشت به فهرست نسخه ها

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Vigeh M, Derek R S, Hsu P. How does lead induce male infertility?. IJRM 2011; 9 (1)
URL: http://ijrm.ir/article-1-203-fa.html

ویژه محسن، اسمیت درک- آر، هو پلینگ چی. چگونه سرب منجر به ناباروری مردان می شود؟. International Journal of Reproductive BioMedicine. 1390; 9 (1)

URL: http://ijrm.ir/article-1-203-fa.html

چگونه سرب منجر به ناباروری مردان می شود؟

محسن ویژه^*

¹، درک- آر اسمیت²

، پلینگ چی هو³

1- گروه برآورد خطرات و تحقیقات اپیدمیولوژی، انستیتوی ملی سلامت ملی سلامت و ایمنی کار، کاوازاکی، ژاپن ، vigeh@h.jniosh.go.jp
2- مدرسه علوم بهداشتی، دانشکده بهداشت، دانشگاه بیوکاسل، اوریمبا، استرالیا
3- گروه ایمنی، بهداشت و مهندسی محیط، اولین دانشگاه ملی علوم و تکنولوژی کاوشینگ، تایوان

چکیده: (4947 مشاهده)

قسمت مهمی از ناباروری مردان با علت نامشخص ممکن است در ارتباط با محیط ها و شغلهای مختلفی باشد که باعث تماس با مواد سمی مانند سرب می شوند. اثرات سرب بر روی تولید مثل پیچیده بوده و مسیرهای مختلفی را در بر می گیرد که بسیاری از آنها هنوز کاملاً شناخته نشده اند. بعنوان مثال هنوز مشخص نیست که مشکلات تولید مثل مردان، تحت تاثیر اثر سرب در ارتباط با توزیع هورمونهای جنسی می باشد یا اینکه بر اثر تاثیر مستقیم سرب بر روی غدد جنسی است و یا هر دو؟
پاسخ به این سوال مشکل می باشد زیرا سرب بخصوص با غلظتهای بالا ممکن است اثرات سوئی بر بسیاری از ارگانهای بدن انسان داشته باشد. هرچند که سرب می تواند بوسیله کاهش در تعداد و حرکت اسپرم ها، بوجود آوردن اشکال غیر طبیعی و همچنین تاثیر بر پارامترهای عملکردی باعث ناباروری درمردان گردد، ولی تمام مطالعات قادر به نشان دادن این موضوع نشده اند. بعلاوه مطالعات نشان داده اند که سد خونی بیضه ها می تواند سلولهای بیضه را در مقابل اثرات مقادیر بالای سرب در خون حفظ نماید. بنا به دلایل ذکر شده و بادر نظر گرفتن اثرات وسیع سرب بر روی هورمونهای تولید مثل، این مطالعه مروری پیشنهاد می کند که اثر اصلی سرب بر روی تولید مثل مردان، احتمالاً بوسیله تغییر دادن محور هورمونهای تولید مثل و کنترل آنها بر روی تولید اسپرم، بجای اثر مستقیم بر روی لوله های اسپرم ساز بیضه عمل می کند. با توجه به آنکه حتی مقادیر کمتر از استاندارد های کاری از غلظت سرب نیز می تواند اثرات سوئی بر روی باروری مردان داشته باشد، لذا مطالعات آینده باید در پی اثبات رابطه بین تماس با سرب ( بخصوص در مقیاس کم) و ناباروری مردان باشند. مطالعات همچنین باید توجه بیشتری به اثرات سرب بر روی کاهش باروری مردان با توجه به تغییرات محور هورمونی و همچنین تغییرات مشخصات اسپرم داشته باشند.

واژه‌های کلیدی: سرب، تولید مثل مردان، ناباروری، هورمونهای تو لید مثل، تولید اسپرم.

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نوع مطالعه: Original Article |

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