International Journal of
Reproductive Biomedicine
Thu, Nov 21, 2024
[Archive]
Volume 20, Issue 1 (January 2022)
IJRM 2022, 20(1): 29-36 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Keikha F, Shahrokh Tehraninejad E, Rakhshkhorshid M, Afiat M, Hagholahi F, Ghasemi F. The association of the betatrophin level with metabolic and inflammatory parameters in infertile women with polycystic ovary syndrome: A case-control study. IJRM 2022; 20 (1) :29-36
URL: http://ijrm.ir/article-1-2045-en.html
URL: http://ijrm.ir/article-1-2045-en.html
Fatemeh Keikha1 
, Ensieh Shahrokh Tehraninejad1 , Marzieh Rakhshkhorshid2 , Malihe Afiat * 3, Fedyeh Hagholahi1 , Fatemeh Ghasemi1
, Ensieh Shahrokh Tehraninejad1 , Marzieh Rakhshkhorshid2 , Malihe Afiat * 3, Fedyeh Hagholahi1 , Fatemeh Ghasemi1
1- Health Reproductive Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Milad Infertility Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ,AfiatM@mums.ac.ir
2- Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Milad Infertility Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ,
Abstract: (1408 Views)
Background: Betatrophin may be associated with metabolic diseases.
Objective: To investigate the betatrophin level and its association with metabolic and inflammatory parameters in infertile women with polycystic ovary syndrome (PCOS) and other infertile women during the intrauterine insemination cycle.
Materials and Methods: This case-control study was conducted with 90 infertile women (45 with PCOS and 45 without) chosen by convenience sampling, in the infertility clinic of Imam Khomeini Hospital in Tehran, Iran. Participants were interviewed to obtain their age, body mass index, and reproductive history. Fasting brachial venous blood samples were obtained on the 3rd day of the menstrual cycle to measure the levels of betatrophin, fasting blood sugar, insulin, luteinizing hormone, follicle-stimulating hormone, low-density lipoprotein cholesterol, estradiol, and high-sensitivity C-reactive protein.
Results: The results showed that the level of betatrophin in women with PCOS was significantly higher than in the control group (p = 0.05). Based on multiple linear regression analyses, the effects of metabolic and inflammatory parameters on betatrophin were not significant (p = 0.19). The results showed no significant difference between groups in folliculogenesis (p = 0.57).
Conclusion: According to the results, betatrophin levels were higher in infertile women with PCOS than in those without. The findings suggest that there may be an association between increased betatrophin and increased incidence of PCOS. Further studies with a larger sample size are needed to investigate the role of betatrophin in insulin resistance and lipid metabolism, and its effects on infertility treatment outcomes.
Objective: To investigate the betatrophin level and its association with metabolic and inflammatory parameters in infertile women with polycystic ovary syndrome (PCOS) and other infertile women during the intrauterine insemination cycle.
Materials and Methods: This case-control study was conducted with 90 infertile women (45 with PCOS and 45 without) chosen by convenience sampling, in the infertility clinic of Imam Khomeini Hospital in Tehran, Iran. Participants were interviewed to obtain their age, body mass index, and reproductive history. Fasting brachial venous blood samples were obtained on the 3rd day of the menstrual cycle to measure the levels of betatrophin, fasting blood sugar, insulin, luteinizing hormone, follicle-stimulating hormone, low-density lipoprotein cholesterol, estradiol, and high-sensitivity C-reactive protein.
Results: The results showed that the level of betatrophin in women with PCOS was significantly higher than in the control group (p = 0.05). Based on multiple linear regression analyses, the effects of metabolic and inflammatory parameters on betatrophin were not significant (p = 0.19). The results showed no significant difference between groups in folliculogenesis (p = 0.57).
Conclusion: According to the results, betatrophin levels were higher in infertile women with PCOS than in those without. The findings suggest that there may be an association between increased betatrophin and increased incidence of PCOS. Further studies with a larger sample size are needed to investigate the role of betatrophin in insulin resistance and lipid metabolism, and its effects on infertility treatment outcomes.
Type of Study: Original Article |
Subject:
Reproductive Endocrinology
References
1. Naghi Jafarabadi M, Mosavi Vahed SH, Afiat M, Ebrahimi Z, Shiva ZS, Haghollahi F. Letrozole plus 2 different gonadotropins regimens for intrauterine insemination in polycystic ovary patients: A randomized clinical trial. Int J Women's Health Reprod Sci 2018; 6: 420-424. [DOI:10.15296/ijwhr.2018.70]
2. Erbag G, Eroglu M, Turkon H, Sen H, Binnetoglu E, Aylanc N, et al. Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome. Cell Mol Biol 2016; 62: 20-24.
3. Calan M, Yilmaz O, Kume T, Kocabas GU, Senses PY, Senses YM, et al. Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome. Endocrine 2016; 53: 271-279. [DOI:10.1007/s12020-016-0875-z] [PMID]
4. Wang H, Du L, Wu T, Yang G, Hu W, Wang H, et al. Circulating betatrophin is associated with insulin resistance in humans: Cross-sectional and interventional studies in vivo and in vitro. Oncotarget 2017; 8: 96604-96614. [DOI:10.18632/oncotarget.21852] [PMID] [PMCID]
5. Ersahin AA, Acet M, Ersahin SS, Acet T, Yardim M, Kenanoglu O, et al. Follicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome. Clin Exp Reprod Med 2017; 44: 33-39. [DOI:10.5653/cerm.2017.44.1.33] [PMID] [PMCID]
6. Haydardedeoglu FE, Bagir GS, Haydardedeoglu B, Bozkirli E, Bakiner O, Metin K, et al. Serum betatrophin levels are reduced in patients with full-blown polycystic ovary syndrome. Gynecol Endocrinol 2019; 35: 224-227. [DOI:10.1080/09513590.2018.1519791] [PMID]
7. Takebayashi K, Hara K, Terasawa T, Naruse R, Suetsugu M, Tsuchiya T, et al. Serum betatrophin levels and clinical features in patients with poorly controlled type 2 diabetes. J Clin Med Res 2017; 9: 782-787. [DOI:10.14740/jocmr3114w] [PMID] [PMCID]
8. Erol O, Özel MK, Ellidağ HY, Toptaş T, Derbent AU, Yılmaz N. Assessment of circulating betatrophin concentrations in lean glucose-tolerant women with polycystic ovary syndrome. J Obstet Gynaecol 2017; 37: 633-638. [DOI:10.1080/01443615.2017.1286464] [PMID]
9. Junjun HE, Honglin HU, Fang DAI. [Serum levels of betatrophin in patients with newly-diagnosed polycystic ovary syndrome and its influential factors]. Anhui Med J 2018; 2: 166-170. (in Chinese)
10. Hassan AB, Salih ShF, Hassan II, Saadi FS, Abdulah DM, Ahmed IH, et al. Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus. Diabetes Metab Syndr 2019; 13: 458-463. [DOI:10.1016/j.dsx.2018.11.016] [PMID]
11. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41-47. [DOI:10.1093/humrep/deh098] [PMID]
12. Knopfholz J, Disserol CCD, Pierin AJ, Schirr FL, Streisky L, Takito LL, et al. Validation of the friedewald formula in patients with metabolic syndrome. Cholesterol 2014; 2014: 261878. [DOI:10.1155/2014/261878] [PMID] [PMCID]
13. McLeod SA. (2019, May 20). What a p-value tells you about statistical significance. Simply Psychology. Available at: www.simplypsychology.org/p-value.html.
14. Qu Q, Zhao D, Zhang F, Bao H, Yang Q. Serum betatrophin levels are increased and associated with insulin resistance in patients with polycystic ovary syndrome. J Int Med Res 2017; 45: 193-202. [DOI:10.1177/0300060516680441] [PMID] [PMCID]
15. Song Sh, Wang J, Guo Ch, Jiang T. [Elevated serum levels of betatrophin in patients with polycystic ovary syndrome and the influential factors]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2016; 41: 969-974. (in Chinese)
16. Abu-Farha M, Sriraman D, Cherian P, AlKhairi I, Elkum N, Behbehani K, et al. Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training. PloS One 2016; 11: e0147367. [DOI:10.1371/journal.pone.0147367] [PMID] [PMCID]
17. Fu Zh, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep 2014; 4: 5013. [DOI:10.1038/srep05013] [PMID] [PMCID]
18. Gómez-Ambrosi J, Pascual E, Catalán V, Rodríguez A, Ramírez B, Silva C, et al. Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. J Clin Endocrinol Metab 2014; 99: E2004-E2009. [DOI:10.1210/jc.2014-1568] [PMID]
19. Battal F, Türkön H, Aylanç N, Aylanç H, Yıldırım Ş, Kaymaz N, et al. Investigation of blood betatrophin levels in obese children with non-alcoholic fatty liver disease. Pediatr Gastroenterol Hepatol Nutr 2018; 21: 111-117. [DOI:10.5223/pghn.2018.21.2.111] [PMID] [PMCID]
20. Abu-Farha M, Abubaker J, Al-Khairi I, Cherian P, Noronha F, Hu FB, et al. Higher plasma betatrophin/ANGPTL8 level in type 2 diabetes subjects does not correlate with blood glucose or insulin resistance. Sci Rep 2015; 5: 10949. [DOI:10.1038/srep10949] [PMID] [PMCID]
21. Duan Y, Liu D, Qu H, Wei H, Luo Y, Feng Zh, et al. Decreased circulating levels of betatrophin in Chinese women with polycystic ovary syndrome. Int J Clin Exp Med 2017; 10: 5196-5202.
22. Ghasemi H, Tavilani H, Khodadadi I, Saidijam M, Karimi J. Circulating betatrophin levels are associated with the lipid profile in type 2 diabetes. Chonnam Med J 2015; 51: 115-119. [DOI:10.4068/cmj.2015.51.3.115] [PMID] [PMCID]
23. Gao T, Jin K, Chen P, Jin H, Yang L, Xie X, et al. Circulating betatrophin correlates with triglycerides and postprandial glucose among different glucose tolerance statuses: A case-control study. PloS One 2015; 10: e0133640. [DOI:10.1371/journal.pone.0133640] [PMID] [PMCID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
