Volume 9, Issue 2 (7-2011)                   IJRM 2011, 9(2): 131-134 | Back to browse issues page

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Asnafi N, Sharbatdaran M, Hajian K. Comparison of maternal and neonatal serum leptin levels in preeclampsia and normal pregnancy. IJRM 2011; 9 (2) :131-134
URL: http://ijrm.ir/article-1-208-en.html
Comparison of maternal and neonatal serum leptin levels in preeclampsia and normal pregnancy
Nesa Asnafi * 1, Majid Sharbatdaran2 , Karimollah Hajian3
1- Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Rohani Hospital, Babol, Iran , swt_f@yahoo.com
2- Department of Clinical Pathology, Babol University of Medical Sciences, Babol, Iran
3- Department of Social and Health Medicine, Babol University of Medical Sciences, Babol, Iran
Abstract:   (2316 Views)
Background: Leptin is a protein product of obesity gene and is synthesized mainly by adipose tissue.
Objective: The aim of this study was to determine maternal and neonatal serum leptin levels in term preeclamptic and normal pregnancies.
Materials and Methods: This cross sectional study was performed on 37 preeclamptic and 40 normotensive term pregnant women without other disease. Serum level of leptin was measured in all of pregnant mothers and after delivery, their neonates. This study was performed in Babol Yahyanejad Hospital from March 2006 to December 2006.
Results: Infants with preeclamptic mothers had significantly lower leptin level than control group (p=0.02). There was no significant difference in serum leptin levels between normal and preeclamptic women (p=0.749).
Conclusion: According to the results, it would be concluded that leptin level in infants of preeclamptic mothers is lower than infants of normal mothers. This can only confirm the diagnosis of disease after birth but it cannot predict the preeclampsia
Keywords: Leptin, Newborn, Pre-eclampsia, Umbilical cord
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Type of Study: Original Article |
References
1. Chan TF, Su JH, Chung YF, Hsu YH, Yeh YT, Jong SB, et al. Amniotic fluid and maternal serum Leptin levels in pregnant women who subsequently develop preeclampsia. Eur J Obstet Gynecol Repord Biol 2003; 108: 50-53. [DOI:10.1016/S0301-2115(02)00414-1]
2. Domali E, Messinis IE. Leptin in pregnancy. J Matern Fetal Neonat Med 2002; 12: 222-230. [DOI:10.1080/jmf.12.4.222.230]
3. Laivuori H, Gallaher MJ, Collura L, Crombleholme WR, Markovic N, Rajakumar A, et al. Relationships between maternal plasma Leptin, Placental Leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. Mol Hum Reprod 2006; 12: 551-556. [DOI:10.1093/molehr/gal064]
4. Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Umbilical cord plasma Leptin is increased in preeclampsia. Am J Obstet Gynecol 2002; 186: 427-432. [DOI:10.1067/mob.2002.120486]
5. Cuningham FG, McDonald PC, Gant NF. Williams obstetrics. 22nd Ed. London; WB Saunders Co.; 2005; 761-798.
6. Baker PN, Kingdom JC: Preeclampsia. 1st Ed. A CRC press Co.; 2004; 119-130.
7. Lepercq J, Cuerre-Millo M, Andre J, Cauzac M, Hauguel-de Meuzon S. Leptin: a potential marker of placental insufficiency. Gynecol Obstet Invest 2003; 55:151-155. [DOI:10.1159/000071529]
8. Lepercq J, Catalano P, Hauguel de Mouzon S. Leptin in pregnancy, Facts questions and future. Gynecol Obstet Fertil 2007; 35:89-95. [DOI:10.1016/j.gyobfe.2006.12.015]
9. Laml T, Preyer O, Hartmann BW, Ruecklinger E , Soeregi G, Wagenbichler P. Decreased maternal serum Leptin in pregnancies complicated by preeclampsia. J Soc Gynecol Investing 2001; 8: 89-93. [DOI:10.1177/107155760100800205]
10. Kauma S, Takacs P, Scordalakes C, walsh S, Green K, Peng T. Increased endothelial monocyte chemoattractant protein -1 and inter-leukin -8 in preeclampsia. Obstet Gynecol 2002; 100: 706-714.
11. Diaz E , Halhali A, Luna C, Diaz L, Avila E, Larrea F. Newborn birth weight correlates with placental zinc, umbilical insulin– like growth factor I ,and Leptin levels in preeclampsia. Arch Med Res 2002; 33: 40-47. [DOI:10.1016/S0188-4409(01)00364-2]
12. Bartha JL, Romero-carmona R, Escobar-Liompart M, Comino-Delgado R. The relationships between Leptin and inflammatory cytkines in women with pre-eclampsia. Br J Obstet Gynecol 2001; 108: 1272-1276. [DOI:10.1016/S0306-5456(01)00284-4]
13. Salvatores M, Gennarelli G, Menato G, Massobrio M. Leptin as apossible marker of augmented metabolic risk during pregnancy. Minerva Ginecol 2006; 58: 1-10.
14. McCarthy JF, Misra DN, Roberts JM. Maternal plasma Leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 1999; 180: 731-736. [DOI:10.1016/S0002-9378(99)70280-2]
15. Adali E, Yildizhan R, Kolusari A, Kurdoglu M, Bugdayci G, Sahin HG, et al. Increased visfatin and leptin in pregnancies complicated by pre-eclampsia. J Matern Fetal Neonatal Med 2009; 22: 873-879. [DOI:10.1080/14767050902994622]
16. Iftikhar U, Iqbal A, Shakoor S. Relationship between leptin and lipids during pre-eclampsia. J Pak Med Assoc 2010; 60: 432-435.
17. Sugathadasa BH, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundere AP. Association of -2548 G/A Polymorphism in the Leptin Gene with Preeclampsia/Pregnancy-induced Hypertension. Hypertens Pregnancy 2010; 29: 366-374. [DOI:10.3109/10641950903214617]
18. Sucak A, Kanat-Pektas M, Gungor T, Mollamahmutoglu L. Leptin levels and antihypertensive treatment in preeclampsia. Singapore Med J 2010; 5: 39-43.
19. Salomon LJ, Benattar C, Audibert F, Fernandez H, Duyme M, Taieb J, et al. Severe preeclampsia is associated with high inhibin a levels and normal Leptin levels 7 to 13 weeks into pregnancy. Am J Obstet Gynecol 2003; 189: 1517- 1522. [DOI:10.1016/S0002-9378(03)00902-5]
20. Martinez-Abundis E, Gonzalez-Ortiz M, Pascoe-Gonzalez S. Serum Leptin levels and the severity of preeclampsia. Arch Gynecol Obstet 2000; 264: 71-73. [DOI:10.1007/s004040000081]
21. Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden AC. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2005; 119: 60-66. [DOI:10.1016/j.ejogrb.2004.06.033]
22. Vitoratos N, Chrystodoulacos G, Kouskouni E, Salamalekis E, Creatsas G. Alterations of maternal and fetal Leptin concentrations in hypertensive disorders of pregnancy. Eur J Obstet Gynecol Repord Biol 2001; 96: 59-62. [DOI:10.1016/S0301-2115(00)00401-2]
23. Hassink SG, de Lancey E, Sheslow DV, Smith-Kirwin SM, O'Connor DM, Considine RV,et al. Placental Leptin: an important new growth factor in intrauterine and neonatal development. Pediatrics 1997; 100:E1. [DOI:10.1542/peds.100.1.e1]
24. Yura S, Sagawa N, Mise H, Mori T, Masuzaki H, Ogawa Y, et al. A positive umbilical venous-arterial difference of Leptin level and its rapid decline after birth. Am J Obstet Gynecol 1998; 178: 926-930. [DOI:10.1016/S0002-9378(98)70525-3]
25. Mise H, Sagawa N, Matsumoto T, Yura S, Nanno H, Itoh H, et al. Augmented placental production of Leptin in pre-eclampsia possible involvement of placental hypoxia. J Clin Endoerinol Metab 1998; 83: 3225-3229.
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