Volume 20, Issue 4 (April 2022)                   IJRM 2022, 20(4): 331-338 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Maghsoumi-Norouzabad L, Labibzadeh M, Zare Javid A, Hosseini S A, Kaydani G A, Dastoorpur M. The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study. IJRM 2022; 20 (4) :331-338
URL: http://ijrm.ir/article-1-2084-en.html
The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study
Leila Maghsoumi-Norouzabad * 1, Maryam Labibzadeh2 , Ahmad Zare Javid3 , Seyed Ahmad Hosseini4 , Gholam Abbas Kaydani5 , Maryam Dastoorpur6
1- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , l.maghsumi55@gmail.com
2- Center of Therapy and Research Infertility Jahad Daneshgahi, Ahvaz, Iran.
3- Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6- Department of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Abstract:   (1415 Views)

 Background: The prevalence of vitamin D deficiency and male infertility is high in Iran.
Objective: The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men.
Materials and Methods: This was a cross-sectional study on 119 infertile men conducted between September 2018 and May 2019. Subjects were divided into 3 groups based on serum vitamin D levels: deficient (< 10 ng/mL), insufficient (10 ng/mL ≤ 25(OH)D ≤ 30 ng/mL), and sufficient (> 30 ng/mL). Body mass index and waist circumference were measured. 25(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed.
Results: The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p < 0.001). Also, in the sufficient group, serum LH (p < 0.001) and estradiol (p < 0.001, p = 0.01) were notably lower and serum sex hormone-binding globulin (p < 0.001) and the testosterone/LH ratio (p < 0.001) were considerably higher compared to the insufficient and deficient groups.
Conclusion: Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males.
Keywords: Infertility, Male, Vitamin D, Semen analysis, Gonadal hormones, Pituitary hormones.
Full-Text [PDF 277 kb]   (846 Downloads) |   |   Full-Text (HTML)  (238 Views)  
Type of Study: Original Article | Subject: Fertility & Infertility
References
1. Abbasihormozi Sh, Kouhkan A, Alizadeh AR, Shahverdi AH, Nasr-Esfahani MH, Sadighi Gilani MA, et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology 2017; 5: 113-118. [DOI:10.1111/andr.12280] [PMID]
2. Holick MF. Vitamin D deficiency. New Engl J Med 2007; 357: 266-281. [DOI:10.1056/NEJMra070553] [PMID]
3. Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 2012; 14: 855-859. [DOI:10.1038/aja.2012.77] [PMID] [PMCID]
4. Blomberg Jensen M, Gerner Lawaetz J, Andersson AM, Petersen JH, Nordkap L, Bang AK, et al. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Hum Reprod 2016; 31: 1875-1885. [DOI:10.1093/humrep/dew152] [PMID]
5. Zhu CL, Xu QF, Li SX, Wei YC, Zhu GC, Yang C, et al. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia 2016; 48: 1261-1266. [DOI:10.1111/and.12570] [PMID]
6. Jorde R, Grimnes G, Hutchinson MS, Kjærgaard M, Kamycheva E, Svartberg J. Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Horm Metab Res 2013; 45: 675-681. [DOI:10.1055/s-0033-1345139] [PMID]
7. Hasanpoor Azghdy SB, Simbar M, Vedadhir A, Hossein Rashidi B. [Psychological impact of infertility among infertile women]. Adv Nurs Midwife 2014; 83: 1-10. (in Persian)
8. Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril 2014; 101: 447-452. [DOI:10.1016/j.fertnstert.2013.10.008] [PMID]
9. Maghsoumi-Norouzabad L, Zare Javid A, Aiiashi S, Hosseini SA, Dadfar M, Bazyar H, et al. The impact of obesity on various semen parameters and sex hormones in Iranian men with infertility: A cross-sectional study. Res Rep Urol 2020; 12: 357-365. [DOI:10.2147/RRU.S258617] [PMID] [PMCID]
10. Catanzariti F, Cantoro U, Lacetera V, Muzzonigro G, Polito M. Comparison between WHO (World Health Organization) 2010 and WHO 1999 parameters for semen analysis: Interpretation of 529 consecutive samples. Arch Ital Urol Androl 2013; 85: 125-129. [DOI:10.4081/aiua.2013.3.125] [PMID]
11. Rehman R, Lalani S, Baig M, Nizami I, Rana Z, Gazzaz ZJ. Association between vitamin D, reproductive hormones and sperm parameters in infertile male subjects. Front Endocrinol 2018; 9: 607. [DOI:10.3389/fendo.2018.00607] [PMID] [PMCID]
12. Blomberg Jensen M. Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction 2012; 144: 135-152. e [DOI:10.1530/REP-12-0064] [PMID]
13. Jueraitetibaike K, Ding Zh, Wang DD, Peng LP, Jing J, Chen L, et al. The effect of vitamin D on sperm motility and the underlying mechanism. Asian J Androl 2019; 21: 400-407. [DOI:10.4103/aja.aja_105_18] [PMID] [PMCID]
14. Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011; 26: 1307-1317. [DOI:10.1093/humrep/der059] [PMID]
15. Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 2011; 95: 1000-1004. [DOI:10.1016/j.fertnstert.2010.11.002] [PMID]
16. Wang N, Han B, Li Q, Chen Y, Chen Y, Xia F, et al. Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from a cross-sectional SPECT-China study. Reprod Biol Endocrinol 2015; 13: 74. [DOI:10.1186/s12958-015-0068-2] [PMID] [PMCID]
17. Zhao D, Ouyang P, de Boer IH, Lutsey PL, Farag YMK, Guallar E, et al. Serum vitamin D and sex hormones levels in men and women: The multi-ethnic study of atherosclerosis (MESA). Maturitas 2017; 96: 95-102. [DOI:10.1016/j.maturitas.2016.11.017] [PMID] [PMCID]
18. Fu L, Chen YH, Xu S, Ji YL, Zhang C, Wang H, et al. Vitamin D deficiency impairs testicular development and spermatogenesis in mice. Reprod Toxicol 2017; 73: 241-249. [DOI:10.1016/j.reprotox.2017.06.047] [PMID]
19. Dufau ML, Catt KJ, Tsuruhara T. Gonadotrophin stimulation of testosterone production by the rat testis in vitro. Biochim Biophys Acta 1971; 252: 574-579. [DOI:10.1016/0304-4165(71)90161-9]
20. Välimäki VV, Alfthan H, Ivaska KK, Löyttyniemi E, Pettersson K, Stenman UH, et al. Serum estradiol, testosterone, and sex hormone-binding globulin as regulators of peak bone mass and bone turnover rate in young Finnish men. J Clin Endocrinol Metab 2004; 89: 3785-3789. [DOI:10.1210/jc.2003-032187] [PMID]
21. Lee DM, Tajar A, Pye SR, Boonen S, Vanderschueren D, Bouillon R, et al. Association of hypogonadism with vitamin D status: The european male ageing study. Eur J Endocrinol 2012; 166: 77-85. [DOI:10.1530/EJE-11-0743] [PMID]
22. Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D. Tissue-selective regulation of aromatase expression by calcitriol: Implications for breast cancer therapy. Endocrinology 2010; 151: 32-42. [DOI:10.1210/en.2009-0855] [PMID] [PMCID]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb