Volume 20, Issue 7 (July 2022)                   IJRM 2022, 20(7): 549-560 | Back to browse issues page


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Dehghan-Manshadi M, Azarbayjani M, Atashak S, Peeri M, Rahmati-Ahmadabad S. Effect of resistance training with and without vitamin D calcium chitosan nanoparticle supplements on apoptosis markers in ovariectomized rats: An experimental study. IJRM. 2022; 20 (7) :549-560
URL: http://ijrm.ssu.ac.ir/article-1-2274-en.html
1- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
2- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. , m_azarbayjani@iauctb.ac.ir
3- Department of Exercise Physiology, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
4- Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
Abstract:   (117 Views)
Background: Hormone therapy is one of the most effective treatments for menopausal disorders, but it may increase the risk of breast cancer, coronary heart disease, and pulmonary embolism.
Objective: The present study investigated the effect of resistance training with and without vitamin D calcium (Ca++) chitosan nanoparticles on apoptosis markers in ovariectomized rats.
Materials and Methods: 42 female Wistar rats were divided into 7 groups (n = 6/each). One group was assigned as the healthy control to show the induction of menopause. The other 6 groups comprised ovariectomized (OVX) animals including: 1) vitamin D + calcium + chitosan + resistance training, 2) saline + estrogen + resistance training, 3) saline + resistance training, 4) vitamin D + calcium + chitosan, 5) saline + estrogen, and 6) OVX + control. 48 hr after the last intervention, the hippocampus tissue was extracted to measure the BCL-2-associated X (BAX), B-cell lymphoma 2 (BCL-2), and caspase-3 gene expression as well as the percentage of dead cells.
Results: OVX rats demonstrated increased BAX gene expression, the ratio of BAX gene expression to BCL-2, caspase-3 gene expression, and percentage of dead cells of hippocampal tissue, but decreased BCL-2 gene expression. Resistance training and vitamin D Ca++ chitosan nanoparticle supplements seemed to reverse these changes.
Conclusion: The combination of resistance training and vitamin D Ca++ chitosan nanoparticle supplements may be considered a non-pharmacological treatment for OVX-induced apoptosis.
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Type of Study: Original Article | Subject: Reproductive Physiology

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