Volume 9, Issue 3 (7-2011)                   IJRM 2011, 9(3): 223-228 | Back to browse issues page

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Hemati T, Moghadami-Tabrizi N, Davari-Tanha F, Salmanian B, Javadian P. High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome. IJRM 2011; 9 (3) :223-228
URL: http://ijrm.ir/article-1-231-en.html
High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome
Tayebe Hemati1 , Nasrin Moghadami-Tabrizi1 , Fateme Davari-Tanha * 2, Bahram Salmanian3 , Pouya Javadian3
1- Department of Obstetrics and Gynecology, Mirza Kouchak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, Mirza Kouchak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran , fatedavari@yahoo.com
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (3001 Views)
Background: Polycystic ovarian syndrome (PCOS) is a common disease among women in fertility ages and cause severe insulin resistance. Hyperhomocysteinaemia is said to be among the features of PCOS that could influence its outcome.
Objective: This study aimed to investigate whether hyperhomocysteinaemia exists in PCOS and if it is related to insulin resistance in the affected patients.
Materials and Methods: This prospective study was carried out in a university based fertility clinic. Sixty four PCOS patients and 50 normo ovulatory controls were reviewed for fasting glucose, insulin, homocysteine, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) plasma levels in the blood sample of the 3rd day of their menstrual cycle. Insulin resistance was determined with the fasting glucose (mmol/L) to insulin (mIU/L) ratio and HOMA-IR (Homeostasis model assessment-Insulin resistance). Independent-samples T-test and linear regression test were utilized to analyze the obtained data.
Results: Homocysteine levels compared between PCOS patients and control group showed a significant difference. PCOS group was divided into insulin resistant (IR) (LogHOMA-IR?0.57) and non insulin resistant (NIR) patients. The IR group had significantly higher homocysteine (p-value=0.02), fasting insulin and glucose levels (p-value<0.001) rather than NIR group.
Conclusion: PCOS patients have a leaning toward hyperhomocysteinaemia and insulin resistance. Insulin resistant patients are found to have higher homocysteine level.
Keywords: PCOS, Homocysteine, Insulin resistance, Infertility.
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Type of Study: Original Article |
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