International Journal of
Reproductive Biomedicine
Mon, Dec 30, 2024
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Volume 21, Issue 3 (March 2023)
IJRM 2023, 21(3): 237-244 |
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Uwejigho R E, Iteire K A, Enemali F U. Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study. IJRM 2023; 21 (3) :237-244
URL: http://ijrm.ir/article-1-2328-en.html
URL: http://ijrm.ir/article-1-2328-en.html
1- Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo State, Laje Campus, Ondo City, Ondo State, Nigeria. , ruwejigho@unimed.edu.ng
2- Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo State, Laje Campus, Ondo City, Ondo State, Nigeria.
2- Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo State, Laje Campus, Ondo City, Ondo State, Nigeria.
Abstract: (709 Views)
Background: Aerva lanata, a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities.
Objective: This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of Aerva lanata.
Materials and Methods: 25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg/kg body weight of Aerva lanata extract, respectively, beginning from 12th to 19th day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.
Results: No gross malformation was observed in the treatment groups, the number of pups/litter was significantly reduced in group E (p = 0.01), pups weight analysis showed a significant reduction in groups C and E (p = 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p = 0.03, 0.03, 0.01, and < 0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose dependent manner compared to the control.
Conclusion: The study revealed a testicular toxicity and possibly antifertility role of Aerva lanata in dams’ pups.
Objective: This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of Aerva lanata.
Materials and Methods: 25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg/kg body weight of Aerva lanata extract, respectively, beginning from 12th to 19th day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.
Results: No gross malformation was observed in the treatment groups, the number of pups/litter was significantly reduced in group E (p = 0.01), pups weight analysis showed a significant reduction in groups C and E (p = 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p = 0.03, 0.03, 0.01, and < 0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose dependent manner compared to the control.
Conclusion: The study revealed a testicular toxicity and possibly antifertility role of Aerva lanata in dams’ pups.
Type of Study: Original Article |
Subject:
Reproductive Biology
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