Volume 21, Issue 3 (March 2023)                   IJRM 2023, 21(3): 255-262 | Back to browse issues page

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Marpaung F R, Priyanto A S, Kusumawati F A, Soehita S, Aryati A. Determination of serum anti-Mullerian hormone levels in a low-prognosis women treated in-vitro fertilization/intracytoplasmic sperm injection: A cohort study. IJRM 2023; 21 (3) :255-262
URL: http://ijrm.ir/article-1-2405-en.html
Determination of serum anti-Mullerian hormone levels in a low-prognosis women treated in-vitro fertilization/intracytoplasmic sperm injection: A cohort study
Ferdy Royland Marpaung * 1, Amang Surya Priyanto2 , Fitri Ayu Kusumawati2 , Sidarti Soehita3 , Aryati Aryati3
1- Department of Clinical Pathology, Faculty of Medicine, Dr Soetomo Academic Hospital, Universitas Airlangga, Surabaya, Indonesia. , ferdyoke@gmail.com
2- IVF Morula Clinic, National Hospital Surabaya, Indonesia.
3- Department of Clinical Pathology, Faculty of Medicine, Dr Soetomo Academic Hospital, Universitas Airlangga, Surabaya, Indonesia.
Abstract:   (729 Views)
Background: Outcome prediction of participants treated with in-vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) using anti-Mullerian hormone (AMH) concentration has been widely used. According to the patient-oriented strategies encompassing individualized oocyte number (POSEIDON) definition, low prognosis Bologna responders have changed from poor. This definition divides low prognosis into 4 groups.
Objective: The purpose of this study was to assess blood AMH levels in the group of women treated with IVF/ICSI who were thought to have a low prognosis.
Materials and Methods: A retrospective cohort study among 252 suspected low-prognosis group participants was assessed between January 2016 and December 2019 at Morula IVF, National hospital, Surabaya, Indonesia. Observed AMH serum levels and pregnancy rates were compared among 4 subgroups.
Results: The AMH cutoff value was 1.7 ng/mL with a sensitivity of 86.7 percent and a specificity of 70% for diagnosing low-prognosis women using POSEIDON criteria. There was no difference in the pregnancy rate between those groups (p > 0.05).
Conclusion: AMH levels may indicate a poor prognosis for women having IVF/ICSI in accordance with POSEIDON guidelines. To predict the poor prognosis in women, the cutoff value must be identified.
Keywords: Prognosis, Assisted reproductive technics, Gonadal hormone, Fertilization in vitro, Reproductive health.
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Type of Study: Original Article | Subject: Assisted Reproductive Technologies
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