Volume 3, Issue 1 (7-2005)                   IJRM 2005, 3(1): 47-49 | Back to browse issues page

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Ilkhanizadeh B, Taghizadieh M, Mahzad-Sadaghiani M, Noroozinia F, Jahandideh B. Bilateral Leydig cell tumor and male infertility: A case report. IJRM 2005; 3 (1) :47-49
URL: http://ijrm.ir/article-1-25-en.html
Abstract:   (2368 Views)
Background: Leydig cell tumor is a rare form of testicular neoplasm which comprises 1-3% of all testicular tumors and only about 3% of these tumors are bilateral. A few Leydig all tumor have been described in patients with klinefelter�s syndrome so far. Case: The patient described in this case report was a 24 year-old man with chief complaint of infertility for one year. Physical examination, semen analysis, testes sonography and hormonal assay were done for him. Right side simple orchiectomy was performed for patient. Conclusion: This tumor is always benign in children and approximately 90% are benign in adults. Clinical presentation is testicular enlargement, gynecomastia, sexual activity disturbances such as decreased libido, infertility and azoospermia. We recommend complete exam and karyotype in patients with infertility and azoospermia.
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References
1. Rathjen J, Lake JA, Bettes MD, Washington JM, Chapman G, Rathjen PD. formation of a primitive ectoderm like cell population, EPL cells from ES cells in response to biologically derived factors. Journal of cell Science 1999; 112: 601-612.
2. Evan MJ, and Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292(9): 154-156. [DOI:10.1038/292154a0] [PMID]
5. Brook FA, and Gardner RL.The origin and efficient derivation of embryonic stem cells in the mouse. Proc. Natl Acad Sci 1997; 94:5709-5712. [DOI:10.1073/pnas.94.11.5709] [PMID] [PMCID]
8. Robertson EJ. Teratocarcinomas and embryonic stem cells: A practical approach. IRL press, Oxford UK 1987; 71-112.
9. Nagy A, Rossant J, Nagy R, Abramow-newerly W, Roder JC. Derivation of completely cell culture -derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 1993; 90:8424-8428. [DOI:10.1073/pnas.90.18.8424] [PMID] [PMCID]
12. Kim NM, Piaytyszk MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific associatian of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015. [DOI:10.1126/science.7605428] [PMID]
15. Doetschman TC, Elistter H, Katz M, Schmidt W, Kemler R. The in vitro development of blastocyst derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morph 1985; 87: 27-45.
16. Voss AK, Thomas T, Gruss P. Germ line chimeras from female ES cells. EXP. Cell Research 1997; 230: 45-49. [DOI:10.1006/excr.1996.3418] [PMID]
19. Thomson JA, Itskovitz-eldor J, Shapiro SS, Waknitz MA, Swieegiel JJ, Marshall VD, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282:1145-1147. [DOI:10.1126/science.282.5391.1145] [PMID]
22. Amit M, and Ltskovitz-Eldor J. Derivation and spontaneous differentiation of human embryonic stem cells. J Anat 2002;200(3):232-255. [DOI:10.1046/j.1469-7580.2002.00032.x] [PMID] [PMCID]
25. Hogan B, Bendington R, Costantini F, Lacy E. Manipulating the Mouse embryo: a laboratory Manual. 2nd Ed. Cold Spring Harbr Laboratory Press 1994; 194-195.
26. Abbondonzo SJ, Gadi I, Stewart CL. Derivation of embryonic stem cell lines. Method of Enzymology1993; 225:803-823. [DOI:10.1016/0076-6879(93)25052-4]
28. Bongso Aniff, Chui-Yee Fong, Soon-Chye Ng, Shan Ratnam. Isolation and culture of inner cell mass from human blastocysts. Human Reproduction 1994; 9:2110-2117. [DOI:10.1093/oxfordjournals.humrep.a138401] [PMID]
31. Schoonjans L, KreemersV, Danloy S, Moreadth W, LarocheY. Improved generation of germ line-competent embryonic stem cell lines from inbred mouse strains. Stem Cells 2003; 21:90-97. [DOI:10.1634/stemcells.21-1-90] [PMID]
34. Odorico JS, Kaufman DA, Thomson JA. Multilinage differentiation from human embryonic stem cell lines. Stem Cells 2001; 19: 193-204. [DOI:10.1634/stemcells.19-3-193] [PMID]
37. .Maya S, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci 2000; 97(21): 11307-11312. [DOI:10.1073/pnas.97.21.11307] [PMID] [PMCID]
40. Itskovitz-Eldor J, Schuldiner M, Karsenti1 D, Eden A, Yanuka A, Amit M, et al. Differentiation of Human Embryonic Stem Cells into Embryoid Bodies Comprising the Three Embryonic Germ Layers. Molecular Medicine 2000; 6(2): 88-95. [DOI:10.1007/BF03401776] [PMID] [PMCID]
43. Petersen BE, Terada N. Stem cells: A Journey into a new frontier. J Am Soc Nephrol 2001; 12: 1773-1780.

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