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Volume 21, Issue 5 (May 2023)
IJRM 2023, 21(5): 379-386 |
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Nasrolahei S, Hosseini S A, Hosseini S A, Hosseini S N K, Hosseini S S, Moradian Lotfi P. Effect of nifedipine with and without sildenafil citrate for the management of preterm labor in pregnant women: A randomized clinical trial. IJRM 2023; 21 (5) :379-386
URL: http://ijrm.ir/article-1-2511-en.html
URL: http://ijrm.ir/article-1-2511-en.html
Shahla Nasrolahei1 
, Seyedeh Arezoo Hosseini * 2, Seyedeh Azadeh Hosseini3 , Seyedeh Narjes Khatoon Hosseini4 , Seyedeh Sahar Hosseini4 , Parsa Moradian Lotfi5
, Seyedeh Arezoo Hosseini * 2, Seyedeh Azadeh Hosseini3 , Seyedeh Narjes Khatoon Hosseini4 , Seyedeh Sahar Hosseini4 , Parsa Moradian Lotfi5
1- Department of Obstetrics and Gynecology, School of Medicine Endometrium and Endometriosis Research Center, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Obstetrics and Gynecology, Zanjan University of Medical Sciences, Zanjan, Iran. , dr.seyedeh_arezoo_hoseini@yhoo.com
3- Iran University of Medical Sciences, Tehran, Iran.
4- Bahçeşehir Medical University Istanbul Turkey, Istanbul, Turkey.
5- Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Obstetrics and Gynecology, Zanjan University of Medical Sciences, Zanjan, Iran. , dr.seyedeh_arezoo_hoseini@yhoo.com
3- Iran University of Medical Sciences, Tehran, Iran.
4- Bahçeşehir Medical University Istanbul Turkey, Istanbul, Turkey.
5- Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract: (527 Views)
Background: Preterm labor is one of the main causes of neonatal mortality and its treatment is still challenging.
Objective: The study aimed to compare the effectiveness of nifedipine (Nif) with and without sildenafil citrate (SC) for the treatment of preterm labor in pregnant women.
Materials and Methods: In this clinical trial study, 126 pregnant women referred to the Fatemieh hospital, Hamadan, Iran with a complaint of preterm labor were evaluated. Participants were randomly divided into 2 groups of Nif 20 mg orally (single dose), then 10 mg every 6-hr, and at the same time vaginal SC 25 mg every 8 hr (Nif + SC) or Nif alone. Treatment was continued for 48-72 hr if uterine contractions did not resolve in both groups. Delivery rates at the time of hospitalization and neonatal outcome were compared between the 2 groups.
Results: No statistically significant difference was observed between the 2 study groups in terms of mean age, gestational age, body mass index, and parity. 76.2% of Nif + SC participants in the first 72 hr of hospitalization and 57.2% of Nif participants remained without delivery (p = 0.02). The neonatal hospitalization rate of the Nif + SC group in the neonatal intensive care unit was 25.4% and in the Nif group was 42.9% (p = 0.03).
Conclusion: Nif with SC is superior to Nif alone in women at risk of preterm labor due to increasing gestational age and better neonatal outcomes.
Objective: The study aimed to compare the effectiveness of nifedipine (Nif) with and without sildenafil citrate (SC) for the treatment of preterm labor in pregnant women.
Materials and Methods: In this clinical trial study, 126 pregnant women referred to the Fatemieh hospital, Hamadan, Iran with a complaint of preterm labor were evaluated. Participants were randomly divided into 2 groups of Nif 20 mg orally (single dose), then 10 mg every 6-hr, and at the same time vaginal SC 25 mg every 8 hr (Nif + SC) or Nif alone. Treatment was continued for 48-72 hr if uterine contractions did not resolve in both groups. Delivery rates at the time of hospitalization and neonatal outcome were compared between the 2 groups.
Results: No statistically significant difference was observed between the 2 study groups in terms of mean age, gestational age, body mass index, and parity. 76.2% of Nif + SC participants in the first 72 hr of hospitalization and 57.2% of Nif participants remained without delivery (p = 0.02). The neonatal hospitalization rate of the Nif + SC group in the neonatal intensive care unit was 25.4% and in the Nif group was 42.9% (p = 0.03).
Conclusion: Nif with SC is superior to Nif alone in women at risk of preterm labor due to increasing gestational age and better neonatal outcomes.
Type of Study: Original Article |
Subject:
Pregnancy Health
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