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Mon, May 13, 2024
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Volume 21, Issue 5 (May 2023)
IJRM 2023, 21(5): 387-394 |
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Soltani S, Aghaee A, Zakavi S R, Mottaghi M, Emadzadeh M, Rahmani S et al . Effects of radioiodine therapy on fertility indicators among men with differentiated thyroid cancer: A cohort study. IJRM 2023; 21 (5) :387-394
URL: http://ijrm.ir/article-1-2543-en.html
URL: http://ijrm.ir/article-1-2543-en.html
Salman Soltani1 
, Atena Aghaee2 , Seyed Rasoul Zakavi2 , Mahdi Mottaghi1 , Maryam Emadzadeh3 , Sahar Rahmani4 , Soheil Kasaeian Naeini * 5
, Atena Aghaee2 , Seyed Rasoul Zakavi2 , Mahdi Mottaghi1 , Maryam Emadzadeh3 , Sahar Rahmani4 , Soheil Kasaeian Naeini * 5
1- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , kasaeianns971@mums.ac.ir
2- Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , kasaeianns971@mums.ac.ir
Abstract: (545 Views)
Background: Following thyroidectomy, radioiodine therapy is the standard management of differentiated thyroid cancer. The effects of such treatment on testicular function remained a concern for cases and clinicians.
Objective: We aimed to observe changes in fertility indicators in men treated with ablation.
Materials and Methods: In this prospective cohort study, 18 men with differentiated thyroid cancer from June to December 2020 underwent thyroidectomy plus radioiodine therapy. Participants were grouped based on iodine dose (8 men with 30 mCi vs. 10 men with ≥ 150 mCi). Baseline values (VB) of the follicular stimulating hormone, luteinizing hormone, testosterone, and sperm analyses were measured 3 wk before iodine ablation and repeated 3 (V3) and 12 (V12) months later. They were analyzed once as a whole and once based on their groups via ANOVA and Friedman's tests where appropriate.
Results: The mean age of participants was 35.61 ± 9.74 yr. Follicular stimulating hormone levels showed a significant trend among all participants (VB: 12.51 ± 1.72, V3: 13.54 ± 1.41, and V12: 13.10 ± 1.67 IU/mL; p < 0.001). Luteinizing hormone showed a similar pattern (VB: 4.98 ± 1.27, V3: 5.65 ± 1.29, and V12: 5.21 ± 0.95 IU/mL; p < 0.001). Testosterone levels did not differ significantly from baseline. Sperm count decreased at the first checkpoint and returned to normal after 12 months (VB: 38.22 ± 19.40, V3: 32.05 ± 17.96, and V12: 36.66 ± 18.81 million/mL; p < 0.001). Sperm motility and morphology did not change significantly.
Conclusion: Our research showed that even less than 5 GBq irradiation could induce a transient testicular dysfunction in the first 3 months of therapy, but it was mostly reversible after 12 months.
Objective: We aimed to observe changes in fertility indicators in men treated with ablation.
Materials and Methods: In this prospective cohort study, 18 men with differentiated thyroid cancer from June to December 2020 underwent thyroidectomy plus radioiodine therapy. Participants were grouped based on iodine dose (8 men with 30 mCi vs. 10 men with ≥ 150 mCi). Baseline values (VB) of the follicular stimulating hormone, luteinizing hormone, testosterone, and sperm analyses were measured 3 wk before iodine ablation and repeated 3 (V3) and 12 (V12) months later. They were analyzed once as a whole and once based on their groups via ANOVA and Friedman's tests where appropriate.
Results: The mean age of participants was 35.61 ± 9.74 yr. Follicular stimulating hormone levels showed a significant trend among all participants (VB: 12.51 ± 1.72, V3: 13.54 ± 1.41, and V12: 13.10 ± 1.67 IU/mL; p < 0.001). Luteinizing hormone showed a similar pattern (VB: 4.98 ± 1.27, V3: 5.65 ± 1.29, and V12: 5.21 ± 0.95 IU/mL; p < 0.001). Testosterone levels did not differ significantly from baseline. Sperm count decreased at the first checkpoint and returned to normal after 12 months (VB: 38.22 ± 19.40, V3: 32.05 ± 17.96, and V12: 36.66 ± 18.81 million/mL; p < 0.001). Sperm motility and morphology did not change significantly.
Conclusion: Our research showed that even less than 5 GBq irradiation could induce a transient testicular dysfunction in the first 3 months of therapy, but it was mostly reversible after 12 months.
Type of Study: Original Article |
Subject:
Fertility & Infertility
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