Volume 21, Issue 7 (July 2023)                   IJRM 2023, 21(7): 541-550 | Back to browse issues page


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Bahramian H, Sherafatmanesh S, Asadi N, Bakhshi A, Eftekhari M H, Ekramzadeh M. Effects of single-dose and co-supplementation of vitamin D and omega-3 on metabolic profile in women with polycystic ovary syndrome: An RCT. IJRM 2023; 21 (7) :541-550
URL: http://ijrm.ir/article-1-2569-en.html
1- Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Nutrition and Food Security Research Center, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5- Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
6- Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Division of Nephrology and Hypertension, Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. , mekramzade@gmail.com
Abstract:   (589 Views)
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous medical condition with a cluster of metabolic and endocrine disorders including dyslipidemia, insulin resistance, and hyperandrogenism.
Objective: The present study aimed to determine the effects of single-dose and co-supplementation of vitamin D (vit D) and omega-3 (O3) on anthropometric and several biochemical factors in women with PCOS.
Materials and Methods: In this double-blind, randomized clinical trial, 80 PCOS women referred to Shahid Motahhari Clinic, Shiraz, Iran, from April to October 2017 were studied in 4 groups (n = 20/each) for 8 wk. The placebo group received the placebo capsule (paraffin oil); 1 weekly and 2/daily; the vit D group received vit D (50,000 IU/weekly) + 2 placebo capsules daily, O3 group,    2, O3 capsules daily + 1 placebo capsule weekly, and vit D + O3 (50000 IU/weekly vit D + 2, O3 capsules daily). Before and after 8 wk of intervention, height, weight, body mass index, waist circumference, triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, homeostasis model of insulin resistance index, and sex hormone binding globulin were compared between groups.
Results: The significant reduction was detected in serum triglyceride (p = 0.002), TC (p = 0.04), fasting blood sugar (p = 0.02), insulin (p = 0.001), and homeostasis model of insulin resistance index (p = 0.001) concentrations in all vit D, O3, and vit D + O3 supplemented groups compared to the placebo group. Furthermore, in comparison with the placebo group, a significant increase was observed in serum sex hormone binding globulin levels after vit D, O3, and vit D + O3 treatments. Nevertheless, no significant changes were observed in serum high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and anthropometric indices in all treated participants.
Conclusion: The current study indicated that single dose and co-supplementation of vit D and O3 for 8 wk was associated with beneficial effects on serum triglyceride, TC, insulin, and sex hormone binding globulin concentrations among women suffering from PCOS.
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Type of Study: Original Article | Subject: Fertility & Infertility

References
1. Koneru A, Priyanka S. Polycystic ovary syndrome (PCOS) and sexual dysfunctions. J Psychosexual Health 2019; 1: 154-158. [DOI:10.1177/2631831819861471]
2. Sherafatmanesh S, Ekramzadeh M, Tanideh N, Golmakani M-T, Koohpeyma F. The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. BMC Complement Med Ther 2020; 20: 249. [DOI:10.1186/s12906-020-03044-w] [PMID] [PMCID]
3. Walters KA, Gilchrist RB, Ledger WL, Teede HJ, Handelsman DJ, Campbell RE. New perspectives on the pathogenesis of PCOS: Neuroendocrine origins. Trends Endocrinol Metab 2018; 29: 841-852. [DOI:10.1016/j.tem.2018.08.005] [PMID]
4. Maktabi M, Jamilian M, Asemi Z. Magnesium-zinc-calcium-vitamin D co-supplementation improves hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Biol Trace Elem Res 2018; 182: 21-28. [DOI:10.1007/s12011-017-1085-0] [PMID]
5. Menichini D, Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: A review. Gynecol Endocrinol 2020; 36: 1-5. [DOI:10.1080/09513590.2019.1625881] [PMID]
6. Renke G, Starling-Soares B, Baesso T, Petronio R, Aguiar D, Paes R. Effects of vitamin D on cardiovascular risk and oxidative stress. Nutrients 2023; 15: 769. [DOI:10.3390/nu15030769] [PMID] [PMCID]
7. He C, Lin Z, Robb SW, Ezeamama AE. Serum vitamin D levels and polycystic ovary syndrome: A systematic review and meta-analysis. Nutrients 2015; 7: 4555-4577. [DOI:10.3390/nu7064555] [PMID] [PMCID]
8. Li HWR, Brereton RE, Anderson RA, Wallace AM, Ho CKM. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism 2011; 60: 1475-1481. [DOI:10.1016/j.metabol.2011.03.002] [PMID]
9. El-Bahya AAZ, Radwanb RA, Gadc MZ, Abdel Maksoudc SM. A closer insight into the role of vitamin D in polycystic ovary syndrome (Pcos). Global J Pharmaceu Sci 2018; 6: 79-87. [DOI:10.19080/GJPPS.2018.06.555692]
10. Phelan N, O'Connor A, Kyaw Tun T, Correia N, Boran G, Roche HM, et al. Hormonal and metabolic effects of polyunsaturated fatty acids in young women with polycystic ovary syndrome: Results from a cross-sectional analysis and a randomized, placebo-controlled, crossover trial. Am J Clin Nutr 2011; 93: 652-662. [DOI:10.3945/ajcn.110.005538] [PMID]
11. Yang K, Zeng L, Bao T, Ge J. Effectiveness of omega-3 fatty acid for polycystic ovary syndrome: A systematic review and meta-analysis. Reprod Biol Endocrinol 2018; 16: 27. [DOI:10.1186/s12958-018-0346-x] [PMID] [PMCID]
12. Monk JM, Turk HF, Liddle DM, De Boer AA, Power KA, Ma DWL, et al. n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer. Nutrients 2014; 6: 4760-4793. [DOI:10.3390/nu6114760] [PMID] [PMCID]
13. Mohammadi E, Rafraf M, Farzadi L, Asghari-Jafarabadi M, Sabour S. Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Asia Pac J Clin Nutr 2012; 21: 511-518.
14. Irani M, Seifer DB, Grazi RV, Julka N, Bhatt D, Kalgi B, et al. Vitamin D supplementation decreases TGF-β1 bioavailability in PCOS: A randomized placebo-controlled trial. J Clin Endocrinol Metab 2015; 100: 4307-4314. [DOI:10.1210/jc.2015-2580] [PMID]
15. Hallal PC, Victora CG. Reliability and validity of the international physical activity questionnaire (IPAQ). Med Sci Sports Exerc 2004; 36: 556. [DOI:10.1249/01.MSS.0000117161.66394.07] [PMID]
16. Rashidi H, Ghaderian SB, Moradi L. The effect of vitamin D3 on improving lipid profile, fasting glucose and insulin resistance in polycystic ovary syndrome women with vitamin D deficiency. Middle East Fertil Soc J 2018; 23: 178-183. [DOI:10.1016/j.mefs.2017.11.002]
17. Wehr E, Trummer O, Giuliani A, Gruber H-J, Pieber TR, Obermayer-Pietsch B. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol 2011; 164: 741-749. [DOI:10.1530/EJE-11-0134] [PMID]
18. Li S, He Y, Lin S, Hao L, Ye Y, Lv L, et al. Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig‐2/SREBP‐2 pathway. Mol Nutr Food Res 2016; 60: 798-809. [DOI:10.1002/mnfr.201500425] [PMID]
19. Kayaniyil S, Vieth R, Harris SB, Retnakaran R, Knight JA, Gerstein HC, et al. Association of 25 (OH) D and PTH with metabolic syndrome and its traditional and nontraditional components. J Clin Endocrinol Metab 2011; 96: 168-175. [DOI:10.1210/jc.2010-1439] [PMID]
20. Gao H, Li Y, Yan W, Gao F. The effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome: A meta-analysis of randomized controlled trials. Int J Endocrinol 2021; 2021: 8849688. [DOI:10.1155/2021/8849688] [PMID] [PMCID]
21. Gerveieeha Z, Siassi F, Qorbani M, Ziaeian F, Sotoudeh G. The effect of different amounts of vitamin D supplementation on serum calcidiol, anthropometric status, and body composition in overweight or obese nursing women: A study protocol for a randomized placebo-controlled clinical trial. Trials 2019; 20: 542. [DOI:10.1186/s13063-019-3622-y] [PMID] [PMCID]
22. Nasiri N, Moini A, Eftekhari-Yazdi P, Karimian L, Salman-Yazdi R, Zolfaghari Z, et al. Abdominal obesity can induce both systemic and follicular fluid oxidative stress independent from polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2015; 184: 112-116. [DOI:10.1016/j.ejogrb.2014.11.008] [PMID]
23. Berry S, Seidler K, Neil J. Vitamin D deficiency and female infertility: A mechanism review examining the role of vitamin D in ovulatory dysfunction as a symptom of polycystic ovary syndrome. J Reprod Immunol 2022; 151: 103633. [DOI:10.1016/j.jri.2022.103633] [PMID]
24. Wimalawansa SJ. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J Steroid Biochem Mol Biol 2018; 175: 177-189. [DOI:10.1016/j.jsbmb.2016.09.017] [PMID]
25. Jamilian M, Samimi M, Mirhosseini N, Afshar Ebrahimi F, Aghadavod E, Talaee R, et al. The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. J Affect Disord 2018; 238: 32-38. [DOI:10.1016/j.jad.2018.05.027] [PMID]
26. Flachs P, Rossmeisl M, Kopecky J. The effect of n-3 fatty acids on glucose homeostasis and insulin sensitivity. Physiol Res 2014; 63 (Suppl.): S93-S119. [DOI:10.33549/physiolres.932715] [PMID]
27. Oner G, Muderris II. Efficacy of omega-3 in the treatment of polycystic ovary syndrome. J Obstet Gynaecol 2013; 33: 289-291. [DOI:10.3109/01443615.2012.751365] [PMID]
28. Jamilian M, Samimi M, Afshar Ebrahimi F, Hashemi T, Taghizadeh M, Razavi M, et al. The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes. J Clin Lipidol 2017; 11: 459-468. [DOI:10.1016/j.jacl.2017.01.011] [PMID]
29. Gurol AO, Okten-Kursun A, Kasapoglu P, Suzergoz F, Kucuksezer UC, Cevik A, et al. The synergistic effect of ω3 and Vit D3 on glycemia and TNF-α in islet transplantation. Cell Mol Biol 2016; 62: 90-98.
30. Davis W, Rockway S, Kwasny M. Effect of a combined therapeutic approach of intensive lipid management, omega-3 fatty acid supplementation, and increased serum 25 (OH) vitamin D on coronary calcium scores in asymptomatic adults. Am J Ther 2009; 16: 326-332. [DOI:10.1097/MJT.0b013e31817a8f3c] [PMID]

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