Volume 21, Issue 5 (May 2023)                   IJRM 2023, 21(5): 433-442 | Back to browse issues page

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Zohrabi T, Sheikhha M H, Jambarsang S, Nadjarzadeh A, Aflatoonian A, Mozaffari-Khosravi H. Effect of dietary approaches to stop hypertension, and standard diets with and without curcumin on interleukin-1 alpha, 5-alpha reductase gene expressions, and androgenic and glycemic profile in polycystic ovary syndrome women undergoing in vitro fertilization treatment: A study protocol. IJRM 2023; 21 (5) :433-442
URL: http://ijrm.ir/article-1-2608-en.html
Effect of dietary approaches to stop hypertension, and standard diets with and without curcumin on interleukin-1 alpha, 5-alpha reductase gene expressions, and androgenic and glycemic profile in polycystic ovary syndrome women undergoing in vitro fertilization treatment: A study protocol
Tayebeh Zohrabi1 , Mohammad Hasan Sheikhha2 , Sara Jambarsang3 , Azadeh Nadjarzadeh1 , Abbas Aflatoonian4 , Hassan Mozaffari-Khosravi * 5
1- Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences,Yazd, Iran.
2- Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5- Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences,Yazd, Iran. , h.mozaffari@ssu.ac.ir
Abstract:   (764 Views)
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases with major reproductive and metabolic complications with an impact on public health. Hyperandrogenism and chronic inflammation have been suggested as the leading cause of pathophysiology and clinical manifestations associated with PCOS. It seems that the altered expression of genes involved in the synthesis of pro-inflammatory cytokine and androgens contribute to the promotion of PCOS.
Objective: This trial aims to determine the effects of dietary approaches to stop hypertension (DASH) and standard diets with and without curcumin supplementation on the gene expression of     interleukin-1 alpha (IL1α), 5α reductase and androgenic and glycemic profile among PCOS patients, who are candidates for in vitro fertilization.
Materials and Methods: 96 infertile women with PCOS, aged 18-40 yr, will participate in this randomized, placebo-controlled clinical trial. Based on treatment conditions and body mass index, the participants will be randomly divided into 4 equal groups using a randomized block design. They will receive a DASH or standard diet containing 52% carbohydrate, 18% protein, and 30% total fat, with the same prescribed sodium, plus 500 mg twice daily curcumin or placebo for 12 wk. The mRNA expression of IL-1α, 5α reductase, and androgenic and glycemic profiles will be measured at baseline and at the end of the study.
Conclusion: Concomitant administration of DASH diet and curcumin supplementation may reduce IL-1α, 5α reductase gene expressions, and improve glycemic and androgenic profiles.
Keywords: Polycystic ovary syndrome, Dietary approaches to stop hypertension, Curcumin, Fertilization in vitro, Gene expression.
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Type of Study: Original Article | Subject: Reproductive Endocrinology
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