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Reproductive Biomedicine
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Volume 10, Issue 2 (7-2012)
IJRM 2012, 10(2): 105-112 |
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Sharami S H, Tangestani A, Faraji R, Zahiri Z, Azam A. Role of dyslipidemia in preeclamptic overweight pregnant women. IJRM 2012; 10 (2) :105-112
URL: http://ijrm.ir/article-1-269-en.html
URL: http://ijrm.ir/article-1-269-en.html
1- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran
2- Reproductive Health Research Center, Guilan University of Medical Sciences, Guilan, Iran
3- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran ,drzibazahiri@yahoo.com
2- Reproductive Health Research Center, Guilan University of Medical Sciences, Guilan, Iran
3- Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran ,
Abstract: (2902 Views)
Background: Obesity is an independent risk factor of preeclampsia with unknown mechanism and hyperlipidemia might be a probable case of it. Objective: The objective of this study was to determine the role of hyper-triglyceridemi in association with high prepregnancy body mass index and the risk of preeclampsia.
Materials and Methods: The authors conducted this case-control study of 42 preeclamptic and 41 normotensive overweight pregnant women. The two groups were comparable with respect to age, gestational age, and body mass index. Blood samples were collected at the time of diagnosis of preeclampsia, after 14 hour fasting to determine plasma lipid concentrations. Enzymatic photometric tests were used to determine lipid profile. Data was analyzed with independent “t-test”, Chi-square and one-way ANOVA and post HOC Tukey HSD test. The statistical significance was set at 0.05 levels. Results: In the subjects with preeclampsia, serum triglyceride and total cholesterol levels were significantly increased and plasma HDL-cholesterol concentrations were decreased compared with the controls, (p<0.05), but plasma LDL cholesterol levels didn’t differ between the two groups. Women who developed severe preeclampsia had higher concentrations of TG and cholesterol and lower levels of HDL compared to noromotensive group. Mean TG: 375.16 vs. 202.85, p<0.001, Mean cholesterol: 245.64 vs. 214.32, p=0.04, Mean HDL: 40.80 vs. 48.95, p=0.03).
Conclusion: We noted that dyslipidemia, particularly hypertriglyceridemia was highly correlated with prepregnancy high BMI in preeclamptic women. These findings continue to support a role for dyslipidemia in BMI related preeclampsia.
Materials and Methods: The authors conducted this case-control study of 42 preeclamptic and 41 normotensive overweight pregnant women. The two groups were comparable with respect to age, gestational age, and body mass index. Blood samples were collected at the time of diagnosis of preeclampsia, after 14 hour fasting to determine plasma lipid concentrations. Enzymatic photometric tests were used to determine lipid profile. Data was analyzed with independent “t-test”, Chi-square and one-way ANOVA and post HOC Tukey HSD test. The statistical significance was set at 0.05 levels. Results: In the subjects with preeclampsia, serum triglyceride and total cholesterol levels were significantly increased and plasma HDL-cholesterol concentrations were decreased compared with the controls, (p<0.05), but plasma LDL cholesterol levels didn’t differ between the two groups. Women who developed severe preeclampsia had higher concentrations of TG and cholesterol and lower levels of HDL compared to noromotensive group. Mean TG: 375.16 vs. 202.85, p<0.001, Mean cholesterol: 245.64 vs. 214.32, p=0.04, Mean HDL: 40.80 vs. 48.95, p=0.03).
Conclusion: We noted that dyslipidemia, particularly hypertriglyceridemia was highly correlated with prepregnancy high BMI in preeclamptic women. These findings continue to support a role for dyslipidemia in BMI related preeclampsia.
Type of Study: Original Article |
References
1. Roberts JM. Pregnancy-related hypertension. In: Creasy K, Resnik R, eds. Maternal-fetal medicine. Philadelphia, PA: W B Saunders Company, 1998: 833-872.
2. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ 2001; 323: 1213-1217. [DOI:10.1136/bmj.323.7323.1213]
3. Bodnar LM, Ness RB, Harger GF, Roberts JM. Inflammation and triglycerides partially mediate the effect of prepregnancy body mass index on the risk of preeclampsia. Am J Epidemiol 2005; 162: 1198-1206. [DOI:10.1093/aje/kwi334]
4. Dekker G, Sibai B. Primary, secondary, and tertiary prevention of pre-eclampsia. Lancet 2001; 357: 209-215. [DOI:10.1016/S0140-6736(00)03599-6]
5. Baksu B, Baksu A, Davas I, Akyol A, Gülbaba G. Lipoprotein (a) levels in women with pre-eclampsia and in normotensive pregnant women. J Obstet Gynaecol Res 2005; 31: 277-282. [DOI:10.1111/j.1447-0756.2005.00276.x]
6. Winkler K, Wetzka B, Hoffmann MM, Friedrich I, Kinner M, Baumstark MW, et al. Triglyceride-rich lipoproteins are associated with hypertension in preeclampsia. J Clin Endocrinol Metab 2003; 88: 1162-1166. [DOI:10.1210/jc.2002-021160]
7. Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens 2004; 17: 574-581. [DOI:10.1016/j.amjhyper.2004.03.666]
8. Ogura K, Miyatake T, Fukui O, Nakamura T, Kameda T, Yoshino G. Low-density lipoprotein particle diameter in normal pregnancy and preeclampsia. J Atheroscler Thromb 2002; 9: 42-47. [DOI:10.5551/jat.9.42]
9. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19: 972-978. [DOI:10.1161/01.ATV.19.4.972]
10. Winkler K, Wetzka B, Hoffmann MM, Friedrich I, Kinner M, Baumstark MW, et al. Triglyceride-rich lipoproteins are associated with hypertension in preeclampsia. J Clin Endocrinol Metab 2003; 88: 1162-1166. [DOI:10.1210/jc.2002-021160]
11. Akhavan S, Modarres Gilani M, Borna S, Shahghaibi S, Yousefinejad V, Shahsavari S. Maternal plasma lipid concentrations in first trimester of pregnancy and risk of severe preeclapmsia. Pak J Med Sci 2009; 25: 563-567.
12. Baker AM, Klein RL, Moss KL, Haeri S, Boggess K. Maternal serum dyslipidemia occurs early in pregnancy in women with mild but not severe preeclampsia. Am J Obstet Gynecol 2009; 201: 293.e1-4. [DOI:10.1016/j.ajog.2009.05.037]
13. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard CJ. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol 1997; 89: 403-408. [DOI:10.1016/S0029-7844(96)00514-5]
14. Hypertensive disorders in pregnancy. In: Cunningham FG, MacDonald PC, Gant NF, et al. Williams Obstetrics, 20th Ed. Connecticut: Appletton and Lange 1997; 693-744.
15. Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia. BJOG 2001; 108: 1081-1087. [DOI:10.1111/j.1471-0528.2001.00247.x]
16. Walsh SW. Obesity: a risk factor for preeclampsia. Trends Endocrinol Metab 2007; 18: 365-370. [DOI:10.1016/j.tem.2007.09.003]
17. Sattar N, Greer IA, Louden J, Lindsay G, McConnell M, Shepherd J, et al. Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small, dense low density lipoprotein. J Clin Endocrinol Metab 1997; 82: 2483-2491. [DOI:10.1210/jc.82.8.2483]
18. Lorentzen B, Henriksen T. Plasma lipids and vascular dysfunction in preeclampsia. Semin Reprod Endocrinol 1998; 16: 33-39. [DOI:10.1055/s-2007-1016250]
19. Couillard C, Ruel G, Archer WR, Pomerleau S, Bergeron J, Couture P, et al. Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab 2005; 90: 6454-6459. [DOI:10.1210/jc.2004-2438]
20. de Man FH, Weverling-Rijnsburger AW, van der Laarse A, Smelt AH, Jukema JW, Blauw GJ. Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation: reversal after lipid-lowering therapy by atorvastatin. Arterioscler Thromb Vasc Biol 2000; 20: 744-750. [DOI:10.1161/01.ATV.20.3.744]
21. Hayman R, Brockelsby J, Kenny L, Baker P. Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J Soc Gynecol Investig 1999; 6: 3-10. [DOI:10.1177/107155769900600103]
22. Sattar N, Greer IA. Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening? BMJ 2002; 325: 157-160. [DOI:10.1136/bmj.325.7356.157]
23. Belogolovkin V, Eddleman KA, Malone FD, Sullivan L, Ball RH, Nyberg DA, et al. The effect of low body mass index on the development of gestational hypertension and preeclampsia. J Matern Fetal Neonatal Med 2007; 20: 509-513. [DOI:10.1080/14767050701420027]
24. Xiao R, Sorensen TK, Williams MA, Luthy DA. Influence of pre-eclampsia on fetal growth. J Matern Fetal Neonatal Med 2003; 13: 157-162. [DOI:10.1080/jmf.13.3.157.162]
25. Stone JL, Lockwood CJ, Berkowitz GS, Alvarez M, Lapinski R, Berkowitz RL. Risk factors for severee preeclampsia. Obstet Gynecol 1994; 83: 357-361.
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