International Journal of
Reproductive Biomedicine
Tue, May 13, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 221-221 |
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Bahrami-Asl Z, Hajipour H, Rastgar Rezaei Y, Novinbahador T, Latifi Z, Nejabati HR, et al . P-54 Cytokines as biomarkers for embryo selection. IJRM 2021; 19 (5) :221-221
URL: http://ijrm.ir/article-1-2852-en.html
URL: http://ijrm.ir/article-1-2852-en.html
Bahrami-Asl Z1 
, Hajipour H2 , Rastgar Rezaei Y *3 , Novinbahador T4 , Latifi Z5 , Nejabati HR6 , Farzadi L7 , Fattahi A8 , Nouri M9 , Dominguez F10
, Hajipour H2 , Rastgar Rezaei Y *3 , Novinbahador T4 , Latifi Z5 , Nejabati HR6 , Farzadi L7 , Fattahi A8 , Nouri M9 , Dominguez F10
1- Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran ,yeganerastgar@gmail.com
4- Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
5- Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6- Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
7- Womenʼs Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
8- Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Womenʼs Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
9- Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
10- Fundacion Instituto Valenciano de Infertilidad (FIVI), Instituto Universitario IVI (IUIVI), ISS LaFe, Valencia, Spain
2- Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran ,
4- Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
5- Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6- Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
7- Womenʼs Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
8- Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Womenʼs Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
9- Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
10- Fundacion Instituto Valenciano de Infertilidad (FIVI), Instituto Universitario IVI (IUIVI), ISS LaFe, Valencia, Spain
Abstract: (277 Views)
Background: Studies have shown that the morphological assessments to select the best embryo for transfer could not provide satisfactory outcomes. Therefore, many studies have been conducted to find predictive biomarkers that can distinguish embryos with high implantation potential.
Objective: In the current study, we comprehensively reviewed the possibility of using embryo-secreted cytokines as potential biomarkers for embryo selection in assisted reproductive technology.
Materials and Methods: The present review involved published research articles that have investigated cytokines in the embryo secretome. A search in Google Scholar and PubMed was performed with no limitation on the date of publication using a combination of the following search terms: “secretome”, “culture media”, and “cytokine (s)”.
Results: It can be postulated that the embryo secretome can well reflect the embryo condition. Since the immune system has an indubitable role in implantation and also the immunological factors are involved in the embryo-endometrial crosstalk, the embryo-secreted cytokines can be used as potential biomarkers.
Conclusion: In conclusion, the following three points should take into consideration while using embryo-secreted factors as biomarkers: 1) The culture media should be evaluated at a certain stage of embryo development (e.g. cleavage and blastocyst), 2) The measurement method should be able to detect very small levels of factors, and 3) Changing in the concentration of several embryo-secreted factors in combination should be evaluated to propose an appropriate embryo selection method.
Objective: In the current study, we comprehensively reviewed the possibility of using embryo-secreted cytokines as potential biomarkers for embryo selection in assisted reproductive technology.
Materials and Methods: The present review involved published research articles that have investigated cytokines in the embryo secretome. A search in Google Scholar and PubMed was performed with no limitation on the date of publication using a combination of the following search terms: “secretome”, “culture media”, and “cytokine (s)”.
Results: It can be postulated that the embryo secretome can well reflect the embryo condition. Since the immune system has an indubitable role in implantation and also the immunological factors are involved in the embryo-endometrial crosstalk, the embryo-secreted cytokines can be used as potential biomarkers.
Conclusion: In conclusion, the following three points should take into consideration while using embryo-secreted factors as biomarkers: 1) The culture media should be evaluated at a certain stage of embryo development (e.g. cleavage and blastocyst), 2) The measurement method should be able to detect very small levels of factors, and 3) Changing in the concentration of several embryo-secreted factors in combination should be evaluated to propose an appropriate embryo selection method.
Type of Study: Congress Abstract |
Subject:
Pregnancy Health
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