International Journal of
Reproductive Biomedicine
Wed, Jul 2, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 231-231 |
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Kheirollahi A. P-64 Polymorphism of hormone-sensitive lipase C-60G in obese and non-obese polycystic ovary syndrome patients. IJRM 2021; 19 (5) :231-231
URL: http://ijrm.ir/article-1-2865-en.html
URL: http://ijrm.ir/article-1-2865-en.html
Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. , kheirolahi_asma@ut.ac.ir
Abstract: (227 Views)
Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder in women of reproductive age. Since most PCOS patients are obese, abnormal lipid metabolism has an essential role in the pathological development of PCOS. Hormone-sensitive lipase (HSL) is an intracellular lipase that has a crucial role in normal lipid metabolism.
Objective: This study aimed to assess the frequency of C-60G polymorphism of HSL in healthy women and PCOS women.
Materials and Methods: 324 women with PCOS and 144 healthy controls were enrolled in this study. All subjects were further divided into Non-PCOS and body mass index (BMI) ≥ 25 (n = 72), PCOS and BMI ≥ 25 (n = 197), Non-PCOS and BMI < 25 (n = 67) and PCOS and BMI < 25 (n = 117) subgroups. Biochemical parameters were measured and the genotypes of C-60G polymorphism of the HSL gene were determined using PCR-restriction fragment length polymorphism techniques.
Results: Age, BMI, Insulin, HOMA-IR, FT, and follicle-stimulating hormone levels were significantly different between subgroups. Our results have shown that there was no significant difference between fasting blood sugar, triglyceride, serum total cholesterol, luteinizing hormone low-density lipoprotein, and high-density lipoproteins levels in cases and controls. The genotypic and allelic frequencies of HSL showed no significant differences between PCOS – with BMI ≥ 25 and/or BMI < 25- and non-PCOS subjects.
Conclusion: According to the obtained results, the C-60G polymorphism in the HSL promoter was not associated with PCOS and BMI.
Objective: This study aimed to assess the frequency of C-60G polymorphism of HSL in healthy women and PCOS women.
Materials and Methods: 324 women with PCOS and 144 healthy controls were enrolled in this study. All subjects were further divided into Non-PCOS and body mass index (BMI) ≥ 25 (n = 72), PCOS and BMI ≥ 25 (n = 197), Non-PCOS and BMI < 25 (n = 67) and PCOS and BMI < 25 (n = 117) subgroups. Biochemical parameters were measured and the genotypes of C-60G polymorphism of the HSL gene were determined using PCR-restriction fragment length polymorphism techniques.
Results: Age, BMI, Insulin, HOMA-IR, FT, and follicle-stimulating hormone levels were significantly different between subgroups. Our results have shown that there was no significant difference between fasting blood sugar, triglyceride, serum total cholesterol, luteinizing hormone low-density lipoprotein, and high-density lipoproteins levels in cases and controls. The genotypic and allelic frequencies of HSL showed no significant differences between PCOS – with BMI ≥ 25 and/or BMI < 25- and non-PCOS subjects.
Conclusion: According to the obtained results, the C-60G polymorphism in the HSL promoter was not associated with PCOS and BMI.
Type of Study: Congress Abstract |
Subject:
Pregnancy Health
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