International Journal of
Reproductive Biomedicine
Wed, Aug 20, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 235-235 |
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Asadi B, Seifi B, Rakhshan K, Kadkhodaee M, Abdi A, Vaziripour M. P-68 Evaluation the effects of polycystic ovarian syndrome-induced by estradiol valerat on ovaries function, oxidative stress and histological changes in female rats. IJRM 2021; 19 (5) :235-235
URL: http://ijrm.ir/article-1-2869-en.html
URL: http://ijrm.ir/article-1-2869-en.html
1- Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , b-asadi@razi.tums.ac.ir
2- Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract: (385 Views)
Background: Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder of women of reproductive age usually accompanied by polycystic ovarian morphology, hyperandrogenism and anovulation or oligomenorrhea.
Objective: The aim of this study is to clarify tissue changes and oxidative stress status in PCOS rats.
Materials and Methods: The PCOS rat model was developed by the once intra muscular injection of Estradiol valerat. Twelve wistar female rats were randomly assigned to two control and PCOS groups. Control group was without any manipulation; PCOS group was administered with Estradiol valerat (4 mg/kg) dissolved in sesame oil (0.2cc); Ovary functional parameters (folliculogenesis, corpora lutea, stage of follicles), SOD activity and MDA levels were measured in ovary samples.
Results: Significant changes were observed in ovary functional parameters, ovarian SOD activity and MDA levels in compared to control group.
Conclusion: This study showed that due to oxidative stress in ovary, the growth of follicles in the preantral stage, folliculogenesis and the number of corpora lutea were changed in PCOS. Therefore, in PCOS the chance of fertility may reduce.
Objective: The aim of this study is to clarify tissue changes and oxidative stress status in PCOS rats.
Materials and Methods: The PCOS rat model was developed by the once intra muscular injection of Estradiol valerat. Twelve wistar female rats were randomly assigned to two control and PCOS groups. Control group was without any manipulation; PCOS group was administered with Estradiol valerat (4 mg/kg) dissolved in sesame oil (0.2cc); Ovary functional parameters (folliculogenesis, corpora lutea, stage of follicles), SOD activity and MDA levels were measured in ovary samples.
Results: Significant changes were observed in ovary functional parameters, ovarian SOD activity and MDA levels in compared to control group.
Conclusion: This study showed that due to oxidative stress in ovary, the growth of follicles in the preantral stage, folliculogenesis and the number of corpora lutea were changed in PCOS. Therefore, in PCOS the chance of fertility may reduce.
Type of Study: Congress Abstract |
Subject:
Pregnancy Health
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