International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 173-173 |
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Bazoobandi S, Tanideh N, Rahmanifar F, Zare S, Koohi-Hosseinabadi O, Razeghian-Jahromi I, et al . P-6 Prevention of uterine fibrosis in rabbit model by intrauterine stem cell conditioned media injection immediately after endometrial curettage. IJRM 2021; 19 (5) :173-173
URL: http://ijrm.ir/article-1-2877-en.html
URL: http://ijrm.ir/article-1-2877-en.html
Bazoobandi S1 
, Tanideh N2 , Rahmanifar F3 , Zare S1 , Koohi-Hosseinabadi O4 , Razeghian-Jahromi I5 , Dianatpour M1 , Ahmadi M1 , Khoradmehr A6 , Nabipour I6 , Khodabandeh Z1 , Tamadon A *7
, Tanideh N2 , Rahmanifar F3 , Zare S1 , Koohi-Hosseinabadi O4 , Razeghian-Jahromi I5 , Dianatpour M1 , Ahmadi M1 , Khoradmehr A6 , Nabipour I6 , Khodabandeh Z1 , Tamadon A *7
1- Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
4- Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
6- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
7- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. ,amintamaddon@gmail.com
2- Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
4- Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
6- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
7- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. ,
Abstract: (293 Views)
Background: Uterine fibrosis or Asherman's syndrome is a uterine acquired disorder with symptoms of implantation disturbances, menstrual irregularities and abortion.
Objective: The main goal of this study was evaluation of the effects of conditioned media of bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs) in prevention of uterine fibrosis immediately after uterine curettage in rabbit.
Materials and Methods: This study included 12 female rabbits (24 uterine horns in total) were randomly divided into four groups of intact negative control, curettage positive control, stem cell therapy, and stem cell conditioned media injection in the way that two corresponding uteri from a rabbit were assigned in different groups.
Results: The BM-MSC-conditioned media treated uterus showed regenerated endometrial layer compared with lower diameter of endometrium in the control group. It showed that BM-MSC-conditioned media play a positive role in the regeneration of the uterine wall. Area of fibrotic tissue in the treated groups was lower than the control groups.
Conclusion: Injected stem cell conditioned media had preventing effect on occurrence of uterine fibrosis. Therefore, BM-MSC-conditioned media can be suggested to be injected immediately after endometrial curettage.
Objective: The main goal of this study was evaluation of the effects of conditioned media of bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs) in prevention of uterine fibrosis immediately after uterine curettage in rabbit.
Materials and Methods: This study included 12 female rabbits (24 uterine horns in total) were randomly divided into four groups of intact negative control, curettage positive control, stem cell therapy, and stem cell conditioned media injection in the way that two corresponding uteri from a rabbit were assigned in different groups.
Results: The BM-MSC-conditioned media treated uterus showed regenerated endometrial layer compared with lower diameter of endometrium in the control group. It showed that BM-MSC-conditioned media play a positive role in the regeneration of the uterine wall. Area of fibrotic tissue in the treated groups was lower than the control groups.
Conclusion: Injected stem cell conditioned media had preventing effect on occurrence of uterine fibrosis. Therefore, BM-MSC-conditioned media can be suggested to be injected immediately after endometrial curettage.
Type of Study: Congress Abstract |
Subject:
Reproductive Endocrinology
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