International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 260-260 |
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Hatami S, Shariatzadeh SMA, Soleimani Mehranjani M. P-93 The effect of Alpha-lipoic acid on oxidative stress in mouse transplanted ovarian tissue. IJRM 2021; 19 (5) :260-260
URL: http://ijrm.ir/article-1-2900-en.html
URL: http://ijrm.ir/article-1-2900-en.html
1- Department of Biology, Faculty of Science, Arak University, Arak, Iran.
2- Department of Biology, Faculty of Science, Arak University, Arak, Iran. ,m-soleimani@araku.ac.ir
2- Department of Biology, Faculty of Science, Arak University, Arak, Iran. ,
Abstract: (236 Views)
Background: Although ovarian tissue transplantation is used to preserve fertility in young women undergoing chemotherapy, but due to the occurrence of ischemia-reperfusion injury and oxidative stress, ovarian function is disturbed and large amounts of follicles are lost. Alpha-lipoic acid (ALA) is a strong free radical scavenger used in the prevention of oxidative stress and cellular damage.
Objective: We aimed to investigate the effect of ALA on the serum level of malondialdehyde (MDA) and total antioxidant capacity (TAC) following mouse ovarian tissue transplantation.
Materials and Methods: 24 mice were randomly divided into: control, autograft (ovarian tissue transplanted to the gluteus superficialis muscle) and autograft + ALA (100 mg/kg intraperitoneal injections of ALA 30minutes prior to transplantation). Serum concentrations of MDA and TAC were measured 7 days after ovary transplantation. Data were analyzed using one-way ANOVA and Tuckey’s test and the means were considered significantly different at p-value < 0.05.
Results: The MDA level in the autograft group significantly increased in compare to the control, while it showed a significant decrease in the autograft + ALA group compared to the autograft group (p < 0.05). Moreover, the serum level of TAC decreased significantly in the autograft group compared to the control counterpart, whereas it increased significantly in the autograft + ALA group compared to the autograft group (p < 0.05).
Conclusion: ALA can reduce oxidative stress and cell damages following ovarian tissue transplantation which can improve the function of the grafted ovary.
Objective: We aimed to investigate the effect of ALA on the serum level of malondialdehyde (MDA) and total antioxidant capacity (TAC) following mouse ovarian tissue transplantation.
Materials and Methods: 24 mice were randomly divided into: control, autograft (ovarian tissue transplanted to the gluteus superficialis muscle) and autograft + ALA (100 mg/kg intraperitoneal injections of ALA 30minutes prior to transplantation). Serum concentrations of MDA and TAC were measured 7 days after ovary transplantation. Data were analyzed using one-way ANOVA and Tuckey’s test and the means were considered significantly different at p-value < 0.05.
Results: The MDA level in the autograft group significantly increased in compare to the control, while it showed a significant decrease in the autograft + ALA group compared to the autograft group (p < 0.05). Moreover, the serum level of TAC decreased significantly in the autograft group compared to the control counterpart, whereas it increased significantly in the autograft + ALA group compared to the autograft group (p < 0.05).
Conclusion: ALA can reduce oxidative stress and cell damages following ovarian tissue transplantation which can improve the function of the grafted ovary.
Type of Study: Congress Abstract |
Subject:
Fertility & Infertility
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