International Journal of
Reproductive Biomedicine
Wed, Aug 20, 2025
[Archive]
Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 261-261 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hatami S, Shariatzadeh SMA, Soleimani Mehranjani M. P-94 Alpha-lipoic acid reduces inflammation in the mouse ovarian tissue following transplantation. IJRM 2021; 19 (5) :261-261
URL: http://ijrm.ir/article-1-2901-en.html
URL: http://ijrm.ir/article-1-2901-en.html
1- Department of Biology, Faculty of Science, Arak University, Arak, Iran. , s.hatami69@gmail.com
2- Department of Biology, Faculty of Science, Arak University, Arak, Iran.
2- Department of Biology, Faculty of Science, Arak University, Arak, Iran.
Abstract: (432 Views)
Background: Ovarian tissue transplantation can restore fertility in cancerous patients. Ischemia-reperfusion injury and inflammation are major restrictions of ovarian tissue transplantation. Alpha-lipoic acid (ALA), as a potent anti-inflammatory and antioxidant agent, is capable of scavenging free radicals.
Objective: We aimed to evaluate the effect of ALA on the serum level of inflammatory factors such as interlukin6, 10 (IL6,10) and Tumor necrosis factor-α (TNF-α) following mouse ovarian tissue transplantation.
Materials and Methods: 24 Mice were divided into: control, autograft + saline (whole ovarian tissue transplanted in the gluteus superficialis muscle, receiving intraperitoneal injections of saline), autograft + ALA (receiving 100 mg/kg" intraperitoneal injections of ALA, 30 minutes before transplantation). 7 days after ovary transplantation, serum concentrations of IL-6, IL-10 and TNF-α were assayed. Data were analyzed using one-way ANOVA and Tuckey’s test and the means were considered significantly different at p-value < 0.05.
Results: Serum concentrations of TNF-α and IL-6 in the autograft group increased significantly compared to the control, while it showed a significant reduction in the autograft + ALA group compared to the autograft group. Moreover, the serum level of IL-10 was significantly lower in the autograft group when compared to the control counterpart. Whereas it showed a significant increase in the autograft + ALA group compared to the autograft group (p < 0.05).
Conclusion: ALA can decrease inflammation through its antioxidant effects, therefore can prevent ischemia-reperfusion induced damages and improve the function of the grafted ovary.
Objective: We aimed to evaluate the effect of ALA on the serum level of inflammatory factors such as interlukin6, 10 (IL6,10) and Tumor necrosis factor-α (TNF-α) following mouse ovarian tissue transplantation.
Materials and Methods: 24 Mice were divided into: control, autograft + saline (whole ovarian tissue transplanted in the gluteus superficialis muscle, receiving intraperitoneal injections of saline), autograft + ALA (receiving 100 mg/kg" intraperitoneal injections of ALA, 30 minutes before transplantation). 7 days after ovary transplantation, serum concentrations of IL-6, IL-10 and TNF-α were assayed. Data were analyzed using one-way ANOVA and Tuckey’s test and the means were considered significantly different at p-value < 0.05.
Results: Serum concentrations of TNF-α and IL-6 in the autograft group increased significantly compared to the control, while it showed a significant reduction in the autograft + ALA group compared to the autograft group. Moreover, the serum level of IL-10 was significantly lower in the autograft group when compared to the control counterpart. Whereas it showed a significant increase in the autograft + ALA group compared to the autograft group (p < 0.05).
Conclusion: ALA can decrease inflammation through its antioxidant effects, therefore can prevent ischemia-reperfusion induced damages and improve the function of the grafted ovary.
Keywords: Ovarian tissue transplantation, Alpha-lipoic acid, Ischemia-reperfusion, Inflammation, Free radicals
Type of Study: Congress Abstract |
Subject:
Fertility & Infertility
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
