International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 264-264 |
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Khazaei F, Niromand E, Ghanbari E, Geravandi E, Khazaei M. P-97 Improving effects of Trifolium pratense extract on histopathological changes in the testis of diabetic rats. IJRM 2021; 19 (5) :264-264
URL: http://ijrm.ir/article-1-2904-en.html
URL: http://ijrm.ir/article-1-2904-en.html
1- Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. , fatima.khazaei78@gmail.com
2- Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract: (197 Views)
Background: Diabetes is the most common endocrine disorders. It has adverse effects on male reproductive function. There are many natural agents available to treat and control diabetes Trifolium pratense L. (T. pratense) has traditionally been used for their anti-diabetic and antioxidant effects.
Objective: The purpose of the current study was to examine the effect of hydroalcoholic extract of T. pratense on testicular tissue changes in diabetic rats.
Materials and Methods: In this study, 42 male Wistar rats (200 ± 10 g) were divided into groups: control, diabetic, 100 and 200 mg/kg doses of T. pratense extract and diabetic treated groups by 100 and 200 mg/kg extract. Rats were treated for 21 days. Diabetes was induced by intraperitoneal injection of streptozotocin at a dose 55 mg/kg. The immunohistochemical expression of bcl-2 and p53 were assessed. Testicular tissue changes were also examined.
Results: The expression of p53 and bcl-2 were increased by diabetes, but it was decreased significantly (p < 0.001) in diabetic treated rats with T. pratense extract. Furthermore, the extract reduced the testicular tissue destruction induced by diabetes.
Conclusion: T. pratense extract improved the undesired side-effects of diabetes on reproductive indices by improved diabetes-induced impairment in testis.
Objective: The purpose of the current study was to examine the effect of hydroalcoholic extract of T. pratense on testicular tissue changes in diabetic rats.
Materials and Methods: In this study, 42 male Wistar rats (200 ± 10 g) were divided into groups: control, diabetic, 100 and 200 mg/kg doses of T. pratense extract and diabetic treated groups by 100 and 200 mg/kg extract. Rats were treated for 21 days. Diabetes was induced by intraperitoneal injection of streptozotocin at a dose 55 mg/kg. The immunohistochemical expression of bcl-2 and p53 were assessed. Testicular tissue changes were also examined.
Results: The expression of p53 and bcl-2 were increased by diabetes, but it was decreased significantly (p < 0.001) in diabetic treated rats with T. pratense extract. Furthermore, the extract reduced the testicular tissue destruction induced by diabetes.
Conclusion: T. pratense extract improved the undesired side-effects of diabetes on reproductive indices by improved diabetes-induced impairment in testis.
Type of Study: Congress Abstract |
Subject:
Fertility & Infertility
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