International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
[Archive]
Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 265-265 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Asadollahi S, Mazaheri Naeini M, Karimi Zarchi M, Fesahat F. P-98 The relationship between FOXR2 gene expression profile and epithelial ovarian cancer. IJRM 2021; 19 (5) :265-265
URL: http://ijrm.ir/article-1-2905-en.html
URL: http://ijrm.ir/article-1-2905-en.html
1- Departments of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Departments of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ,mazaheri54@yahoo.com
3- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Departments of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ,
3- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (255 Views)
Background: Several factors have been evaluated for their competency as applied biomarkers regarding diagnosis and therapy of ovarian cancer as one of the most causes of death due to gynecologic malignancies. However, some Fox-factors have been shown to modulate cancer progression primarily by their impacts on the proliferation of the cells, the expression and potential function of FOXR2 (Forkhead Box R2), newly identified as a probable oncogene in a few human cancers, remains undecided in ovarian cancer.
Objective: The aim was to evaluate the FOXR2 and some epithelial-mesenchymal transition (EMT) related genes expression profiles in epithelial ovarian cancer (EOC) tissues and their healthy samples as well as an ovarian cancer cell line (SKOV-3).
Materials and Methods: In this observational study, twenty epithelial ovarian adenocarcinoma (case group) and their marginal samples (controls), obtained from 20 patients with EOC, besides SKOV-3, were investigated for the relative gene expression levels of FOXR2, CDH1 (encoding E-cadherin), and FN1 (fibronectin-1) in two groups using qualitative real-time PCR (qRT-PCR) technique.
Results: The findings demonstrated a significant up-regulation of FOXR2 and FN1 despite the CDH1 down-regulation in case samples compared to controls (p < 0.05). There was a significant correlation between FOXR2 gene expression profile and EMT-related markers in high-grade tumors. Furthermore, the biomarker index of 0.772 was obtained for FOXR2 gene expression levels.
Conclusion: The findings indicated that the expression levels of FOXR2 have a significant association with ovarian cancer as far as it can be used as a diagnostic and therapeutic molecular biomarker in ovarian cancer.
Objective: The aim was to evaluate the FOXR2 and some epithelial-mesenchymal transition (EMT) related genes expression profiles in epithelial ovarian cancer (EOC) tissues and their healthy samples as well as an ovarian cancer cell line (SKOV-3).
Materials and Methods: In this observational study, twenty epithelial ovarian adenocarcinoma (case group) and their marginal samples (controls), obtained from 20 patients with EOC, besides SKOV-3, were investigated for the relative gene expression levels of FOXR2, CDH1 (encoding E-cadherin), and FN1 (fibronectin-1) in two groups using qualitative real-time PCR (qRT-PCR) technique.
Results: The findings demonstrated a significant up-regulation of FOXR2 and FN1 despite the CDH1 down-regulation in case samples compared to controls (p < 0.05). There was a significant correlation between FOXR2 gene expression profile and EMT-related markers in high-grade tumors. Furthermore, the biomarker index of 0.772 was obtained for FOXR2 gene expression levels.
Conclusion: The findings indicated that the expression levels of FOXR2 have a significant association with ovarian cancer as far as it can be used as a diagnostic and therapeutic molecular biomarker in ovarian cancer.
Type of Study: Congress Abstract |
Subject:
Fertility & Infertility
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
