International Journal of
Reproductive Biomedicine
Fri, Aug 22, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 204-204 |
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Emami N, Alizadeh AR, Moini A, Yaghmaei P, Shahhosseini M. P-37 The association between fatty acids and steroids gene expression in abdominal subcutaneous fat depot: A comparison between pregnant PCOS and non-PCOS pregnant women. IJRM 2021; 19 (5) :204-204
URL: http://ijrm.ir/article-1-2919-en.html
URL: http://ijrm.ir/article-1-2919-en.html
1- Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , neda.emami58@gmail.com
2- Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
3- Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran. Department of Gynecology and Obstetrics, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
5- Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
2- Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
3- Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran. Department of Gynecology and Obstetrics, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
5- Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
Abstract: (355 Views)
Background: It was reported that steroid-related gene expressions in the adipose tissue (AT) of women differ between women affected with polycystic ovary syndrome (PCOS) (case) and non-PCOS (control). Although association between PCOS in mother and offspring’s health is a crucial issue, there are few studies focusing on effectiveness of AT profiles on steroids genes expression in pregnant women suffering from PCOS.
Objective: Our objectives were to assess association between fatty acid (FA) and genes related to steroids metabolism expression in abdominal subcutaneous AT of 12 PCOS (case) vs. 32 non-PCOS (control) age- and BMI-matched pregnant women.
Materials and Methods: Twelve pregnant women with PCOS (case) and thirty two non-PCOS pregnant women (control) (age- and BMI-matched) undergoing cesarean section were enrolled for the present study. Expressions of fifteen genes related to steriodogenesis in abdominal subcutaneous AT were investigated using quantitative real-time PCR. Fatty acids profiles assessed by gas chromatography. Linear regression was performed to determine the association of FA and gene expression in subcutaneous AT.
Results: Age and BMI were similar among two groups at delivery day. Current study showed that omega-3 fatty acids had the highest association with steroids gene expression rate (r = 0.500; p < 0.05).
Conclusion: It seems that fatty acids, both direct and by metabolites, can play a role in many diseases through extensive signaling pathways, specifically in exacerbating PCOS, although pregnancy can double the role of nutrition in exacerbating these effects.
Objective: Our objectives were to assess association between fatty acid (FA) and genes related to steroids metabolism expression in abdominal subcutaneous AT of 12 PCOS (case) vs. 32 non-PCOS (control) age- and BMI-matched pregnant women.
Materials and Methods: Twelve pregnant women with PCOS (case) and thirty two non-PCOS pregnant women (control) (age- and BMI-matched) undergoing cesarean section were enrolled for the present study. Expressions of fifteen genes related to steriodogenesis in abdominal subcutaneous AT were investigated using quantitative real-time PCR. Fatty acids profiles assessed by gas chromatography. Linear regression was performed to determine the association of FA and gene expression in subcutaneous AT.
Results: Age and BMI were similar among two groups at delivery day. Current study showed that omega-3 fatty acids had the highest association with steroids gene expression rate (r = 0.500; p < 0.05).
Conclusion: It seems that fatty acids, both direct and by metabolites, can play a role in many diseases through extensive signaling pathways, specifically in exacerbating PCOS, although pregnancy can double the role of nutrition in exacerbating these effects.
Type of Study: Congress Abstract |
Subject:
Reproductive Pattology
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