International Journal of
Reproductive Biomedicine
Wed, Aug 20, 2025
[Archive]
Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 209-209 |
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Vatannejad A. P-42 Circulating level of plasma Complement C1q/tumor necrosis factor-related protein 15 in polycystic ovary syndrome. IJRM 2021; 19 (5) :209-209
URL: http://ijrm.ir/article-1-2926-en.html
URL: http://ijrm.ir/article-1-2926-en.html
Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran , vatannejad@ ut.ac.ir
Abstract: (316 Views)
Background: Poly-cystic ovarian syndrome (PCOS) is one of the frequent metabolic and endocrine disorder in women population that has a close relation with parameters of metabolic syndrome and obesity. Studies have shown perturbation of adipokines levels in PCOS patients. Complement C1q/tumor necrosis factor-related protein 15 (CTRP15) is a prologue of adiponectin that indicated a close relation with insulin, glucose and lipids metabolism.
Objective: In the present study we sought to evaluate the levels of this adipokines and its relation with cardiometabomic data.
Materials and Methods: This case-control study carried out on 120 PCOS patients and 60 controls. Serum levels of adiponectin and CTRP15 were determined using ELISA technique.
Results: Serum levels of CTRP15 elevated in patients with PCOS compared to controls while adiponectin decreased considerably. In addition, CTRP15 indicated a relation with BMI, insulin resistance and FSH levels.
Conclusion: Elevated levels of CTRP15 could be a compensatory response in patients with PCOS in response to obesity and insulin resistance, however further studies are needed to dissect the possible underlying mechanism.
Objective: In the present study we sought to evaluate the levels of this adipokines and its relation with cardiometabomic data.
Materials and Methods: This case-control study carried out on 120 PCOS patients and 60 controls. Serum levels of adiponectin and CTRP15 were determined using ELISA technique.
Results: Serum levels of CTRP15 elevated in patients with PCOS compared to controls while adiponectin decreased considerably. In addition, CTRP15 indicated a relation with BMI, insulin resistance and FSH levels.
Conclusion: Elevated levels of CTRP15 could be a compensatory response in patients with PCOS in response to obesity and insulin resistance, however further studies are needed to dissect the possible underlying mechanism.
Type of Study: Congress Abstract |
Subject:
Reproductive Pattology
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