International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
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Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 185-185 |
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Sanamiri K, Soleimani Mehranjani M, Shahhoseini M, Shariatzadeh S. P-18 L-carnitine reduces inflammation and oxidative stress in mouse ovarian tissue following autotransplantation. IJRM 2021; 19 (5) :185-185
URL: http://ijrm.ir/article-1-2929-en.html
URL: http://ijrm.ir/article-1-2929-en.html
1- Department of Biology, Faculty of Science, Arak University, Arak, Iran.
2- Department of Biology, Faculty of Science, Arak University, Arak, Iran. ,m-soleimani@araku.ac.ir
3- Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
2- Department of Biology, Faculty of Science, Arak University, Arak, Iran. ,
3- Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Abstract: (276 Views)
Background: Transplantation of ovarian tissue is a fertility restoration technique in patients undergoing chemotherapy and radiotherapy. A major issue associated with ovarian transplantation is ischemia/reperfusion injury that leads to depletion and apoptosis of follicles. L-carnitine has antioxidant and anti-inflammation properties and can therefore be used to reduce ischemic damages.
Objective: The aim of this study was to investigate the effect of L-carnitine injection on transplanted mouse ovarian tissue.
Materials and Methods: The Naval Medical Research Institute (NMRI) mice at the age of 4-5 weeks, were divided randomly into groups of: Control, autograft and autograft + L-carnitine (200 mg/kg daily intrapritoneal injections). Seven days post ovary autografting, serum levels of Malondialdehyde (MDA), total antioxidant capacity, tumor necrosis factor alpha (TNF-α), interleukin (IL)-6 and IL-10 were measured. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey test, and the means were considered significantly different at p < 0.05.
Results: A significant increase was found in the serum level of IL-6, TNF-α and MDA in the autograft group compared to the control counterpart whereas the mentioned parameters reduced significantly in the autograft+L-carnitine group. The Total antioxidant capacity and the serum level of IL-10 also revealed a significant decrease in the autograft group when compared to the control while they significantly increased in the autograft+L-carnitine group.
Conclusion: L-carnitine could reduce oxidative stress and inflammation following mouse ovarian tissue transplantation.
Objective: The aim of this study was to investigate the effect of L-carnitine injection on transplanted mouse ovarian tissue.
Materials and Methods: The Naval Medical Research Institute (NMRI) mice at the age of 4-5 weeks, were divided randomly into groups of: Control, autograft and autograft + L-carnitine (200 mg/kg daily intrapritoneal injections). Seven days post ovary autografting, serum levels of Malondialdehyde (MDA), total antioxidant capacity, tumor necrosis factor alpha (TNF-α), interleukin (IL)-6 and IL-10 were measured. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey test, and the means were considered significantly different at p < 0.05.
Results: A significant increase was found in the serum level of IL-6, TNF-α and MDA in the autograft group compared to the control counterpart whereas the mentioned parameters reduced significantly in the autograft+L-carnitine group. The Total antioxidant capacity and the serum level of IL-10 also revealed a significant decrease in the autograft group when compared to the control while they significantly increased in the autograft+L-carnitine group.
Conclusion: L-carnitine could reduce oxidative stress and inflammation following mouse ovarian tissue transplantation.
Type of Study: Congress Abstract |
Subject:
Reproductive Pattology
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