International Journal of
Reproductive Biomedicine
Wed, May 14, 2025
[Archive]
Volume 19, Issue 5 (Suppl- 2021)
IJRM 2021, 19(5): 316-316 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Aghajani Sh, Mehrafza M, Ahmad H, Salehzadeh A, Ghasemiyan F, Eftekhari A, et al . P-149 The impact of paternal age on sex chromosomes aneuploidy, blastocyst rate and quality with pregnancy outcomes. IJRM 2021; 19 (5) :316-316
URL: http://ijrm.ir/article-1-3059-en.html
URL: http://ijrm.ir/article-1-3059-en.html
Aghajani Sh *1 
, Mehrafza M2 , Ahmad H2 , Salehzadeh A3 , Ghasemiyan F4 , Eftekhari A2 , Vahabzadeh H2 , Porseifi G2
, Mehrafza M2 , Ahmad H2 , Salehzadeh A3 , Ghasemiyan F4 , Eftekhari A2 , Vahabzadeh H2 , Porseifi G2
1- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran. , shahrzadaghajani1987@gmail.com
2- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.
4- Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
2- Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.
4- Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
Abstract: (220 Views)
Background: Postponing childbirth by couples in developed countries is increasing. Paternal age has been ascending between all educational levels, races, and geographic regions. Over the past four decades, the percentage of fathers older than 40 years has doubled, from 4.1% to 8.9%. Therefore, investigating a possible correlation between chromosomal aneuploidy and paternal age, analyzing embryos derived from the frozen and fresh embryo transfer is questionable.
Objective: The present study aimed to evaluate the probable effect of paternal age on aneuploidy, blastocyst rate, embryo development, implantation potential, and pregnancy outcomes in preimplantation genetic testing (PGT) cycle with single blastomere biopsy on the day three by fluorescence in situ hybridization (FISH) for sex chromosomes.
Materials and Methods: The present study included 277 embryos between February 2018 and June 2020. Seventy-six women underwent intracytoplasmic sperm injection with preimplantation genetic testing for aneuploidy using fluorescence in situ hybridization method cycles were divided into four paternal age groups: ≤ 35, 36-40, 41-45, and ≥ 45 yr. Primary outcomes were the rate of aneuploidy, blastocyst, and pregnancy. Statistical analyzes were performed using SPSS software version 23 and the data were analyzed using the χ2 test. The p < 0.05 was considered statistically significant.
Results: Significant differences among four groups in chemical pregnancy (p < 0.001), clinical pregnancy (p < 0.001), ongoing pregnancy (p < 0.001) and live birth rate (p = 0.22) were found. There was no early pregnancy loss and clinical pregnancy loss in cycles with paternal age under 35 yr rate (p < 0.01). The rate of aneuploidy in sex chromosomes, embryo development in frozen embryo transfer, and fresh cycle were not significantly related to parental age.
Conclusion: We didn’t find any significant relationship between paternal age and embryo aneuploidy but an association was found between paternal age and pregnancy outcome in embryos from intracytoplasmic sperm injection cycles.
Objective: The present study aimed to evaluate the probable effect of paternal age on aneuploidy, blastocyst rate, embryo development, implantation potential, and pregnancy outcomes in preimplantation genetic testing (PGT) cycle with single blastomere biopsy on the day three by fluorescence in situ hybridization (FISH) for sex chromosomes.
Materials and Methods: The present study included 277 embryos between February 2018 and June 2020. Seventy-six women underwent intracytoplasmic sperm injection with preimplantation genetic testing for aneuploidy using fluorescence in situ hybridization method cycles were divided into four paternal age groups: ≤ 35, 36-40, 41-45, and ≥ 45 yr. Primary outcomes were the rate of aneuploidy, blastocyst, and pregnancy. Statistical analyzes were performed using SPSS software version 23 and the data were analyzed using the χ2 test. The p < 0.05 was considered statistically significant.
Results: Significant differences among four groups in chemical pregnancy (p < 0.001), clinical pregnancy (p < 0.001), ongoing pregnancy (p < 0.001) and live birth rate (p = 0.22) were found. There was no early pregnancy loss and clinical pregnancy loss in cycles with paternal age under 35 yr rate (p < 0.01). The rate of aneuploidy in sex chromosomes, embryo development in frozen embryo transfer, and fresh cycle were not significantly related to parental age.
Conclusion: We didn’t find any significant relationship between paternal age and embryo aneuploidy but an association was found between paternal age and pregnancy outcome in embryos from intracytoplasmic sperm injection cycles.
Type of Study: Congress Abstract |
Subject:
Reproductive Genetics
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
