Volume 10, Issue 5 (10-2012)                   IJRM 2012, 10(5): 441-452 | Back to browse issues page

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Amirzargar M A, Yavangi M, Basiri A, Hosseini Moghaddam S M, Babbolhavaeji H, Amirzargar N, et al . Comparison of recombinant human follicle stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on semen parameters after varicocelectomy: a randomized clinical trial. IJRM 2012; 10 (5) :441-452
URL: http://ijrm.ir/article-1-309-en.html
Comparison of recombinant human follicle stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on semen parameters after varicocelectomy: a randomized clinical trial
Mohammad Ali Amirzargar * 1, Mahnaz Yavangi2 , Abbass Basiri3 , Sayyed Mahdi Hosseini Moghaddam3 , Hooshang Babbolhavaeji4 , Nasibeh Amirzargar3 , Hossein Amirzargar3 , Leila Moadabshoar3
1- Department of Urology, Hamadan University of Medical Sciences, Hamadan, Iran , dr_amirzargar@yahoo.com
2- Department of Obstetrics and Gynecology, Fatemieh Infertility Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Department of Urology, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (5317 Views)
Background: The most frequent physical finding in infertile men is varicocele, in which one of the mechanisms that can affect seminal parameters is oxidative stress.
Objective: Our study aimed, for the first time, to compare the efficacy of recombinant human follicle-stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on sperm parameters and fertility after varicocelectomy.
Materials and Methods: 113 infertile men with varicocele were divided into four groups. Group A received HCG 5000 IU weekly, group B received HMG 75 IU three times a week, group C received rhFSH 75 IU three times a week and group D received no medical treatment after varicocelectomy.
Results: After three months, in group A sperm morphology improved (p=0.007), causing a 32% pregnancy rate. In group B, sperm motility (p=0.023) and morphology (p=0.014) improved, causing a 57% pregnancy rate. In group C, all of the investigated semen parameters increased (p<0.05), causing a 62.5% pregnancy rate. Only rhFSH improved sperm concentrations to >20×106 mL (p=0.027). In group D, sperm morphology increased (p=0.038), but other parameters remained unchanged and no pregnancies occurred.
Conclusion: It can be concluded that drugs can reduce induction time for spermatogenesis and fertility in comparison with varicocelectomy alone. For these purposes, rhFSH is more effective than other drugs.
Keywords: Male Infertility, Semen Analyses, Varicocele, Varicocelectomy, HCG, HMG, rhFSH
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Type of Study: Original Article |
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