Volume 10, Issue 5 (10-2012)                   IJRM 2012, 10(5): 465-472 | Back to browse issues page

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Bonakdaran S, Mazloom Khorasani Z, Davachi B, Mazloom Khorasani J. The effects of calcitriol on improvement of insulin resistance, ovulation and comparison with metformin therapy in PCOS patients: a randomized placebo- controlled clinical trial. IJRM 2012; 10 (5) :465-472
URL: http://ijrm.ir/article-1-312-en.html
The effects of calcitriol on improvement of insulin resistance, ovulation and comparison with metformin therapy in PCOS patients: a randomized placebo- controlled clinical trial
Shokoufeh Bonakdaran * 1, Zahra Mazloom Khorasani2 , Behrooz Davachi3 , Javad Mazloom Khorasani4
1- Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , bonakdaransh@mums.ac.ir
2- Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of Radiology, Radiology Center, Mashhad University of Medical Sciences, Mashhad, Iran
4- Imam Reza Hospital, Mashhad, Iran
Abstract:   (3226 Views)
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age. Insulin resistance is a frequent metabolic disturbance in PCOS. Vitamin D deficiency is a common problem. Accumulating evidence suggests that vitamin D has a role on insulin sensitivity so may contribute to reduction of hyperandrogenemia.
Objective: The aim was to determine the effects of vitamin D treatment in metabolic components and ovulation evidence in PCOS.
Materials and Methods: Fifty one untreated PCOS patients were randomly divided into three groups and treated with calcitriol, metformin, or placebo. Before and 3 months after treatment, ovulation evidence was assessed by ovarian trans abdominal sonography. Plasma fasting glucose, insulin, homeostasis model assessment insulin resistance (HOMA-IR), 25-hydroxyvitamin D, parathyroid hormone and androgen levels were measured before and after treatment. A 75gr glucose test was performed before and after treatment and two set of results was compared.
Results: Three patients did not continue this study. Only 11 patient (22.9%) had sufficient vitamin D levels (>30 ng/ml). Metformin caused a significant decrease in weight (p=0.027), insulin level (p=0.043), and insulin resistance (p=0.048). Systolic blood pressure and PTH significantly improved after calcitriol (p=0.029, p=0.009 respectively). An improvement in ovulation was detected after calcitriol and seven patients, without evidence of ovulation before treatment, illustrated ovulation after 3 months. Difference with calcitriol in ovulation was significant versus other two methods (p=0.02). Conclusion: Calcitriol treatment in PCOS may be prior to metformin in ovulation induction.
Keywords: PCOS, Ovulation, Vitamin D, Insulin resistance
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Type of Study: Original Article |
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