International Journal of
Reproductive Biomedicine
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Volume 21, Issue 10 (October 2023)
Int J Reprod BioMed. 2023, 21(10): 777-788 |
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Bahreiny S S, Ahangarpour A, Hemmati A A, Kazemzadeh R, Bastani M, Dabbagh M R et al . Circulating nesfatin-1 levels in women with polycystic ovary syndrome: A systematic review and meta-analysis. Int J Reprod BioMed. 2023; 21 (10) :777-788
URL: http://ijrm.ir/article-1-3128-en.html
URL: http://ijrm.ir/article-1-3128-en.html
Seyed Sobhan Bahreiny1 
, Akram Ahangarpour *2 , Ali Asghar Hemmati3 , Razieh Kazemzadeh1 , Mohammad-Navid Bastani1 , Mohammad Reza Dabbagh4 , Mojtaba Aghaei1
, Akram Ahangarpour *2 , Ali Asghar Hemmati3 , Razieh Kazemzadeh1 , Mohammad-Navid Bastani1 , Mohammad Reza Dabbagh4 , Mojtaba Aghaei1
1- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Golestan St., Ahvaz, Iran. Postal Code: 61357-15794
2- Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,akramahangarpour@gmail.com
3- Marine Pharmaceutical Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ., Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Golestan St., Ahvaz, Iran. Postal Code: 61357-15794
4- Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Golestan St., Ahvaz, Iran. Postal Code: 61357-15794
2- Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,
3- Marine Pharmaceutical Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ., Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Golestan St., Ahvaz, Iran. Postal Code: 61357-15794
4- Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Golestan St., Ahvaz, Iran. Postal Code: 61357-15794
Abstract: (2131 Views)
Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in females. Nesfatin-1 is a neuropeptide synthesized in the hypothalamus and other peripheral organs, and there are conflicting opinions about its correlation with PCOS.
Objective: This study aims to investigate the correlation between nesfatin-1 and PCOS and evaluates the effectiveness of nesfatin-1 as a biomarker for the detection of PCOS in women.
Materials and Methods: A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science, Cochrane, EMBASE, Scopus, and Google Scholar. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity.
Results: The meta-analysis involved 12 studies with 1222 participants, and the findings revealed a significant relationship between PCOS and nesfatin-1 levels. The pooled (SMD = 0.54; 95% CI: 0.00-1.07; p = 0.04) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-1 levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 1.46; 95% CI: 0.92-2.00; p < 0.001).
Conclusion: Our meta-analysis indicates an association between high nesfatin-1 levels and PCOS. This suggests a potential role of nesfatin-1 in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings.
Objective: This study aims to investigate the correlation between nesfatin-1 and PCOS and evaluates the effectiveness of nesfatin-1 as a biomarker for the detection of PCOS in women.
Materials and Methods: A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science, Cochrane, EMBASE, Scopus, and Google Scholar. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity.
Results: The meta-analysis involved 12 studies with 1222 participants, and the findings revealed a significant relationship between PCOS and nesfatin-1 levels. The pooled (SMD = 0.54; 95% CI: 0.00-1.07; p = 0.04) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-1 levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 1.46; 95% CI: 0.92-2.00; p < 0.001).
Conclusion: Our meta-analysis indicates an association between high nesfatin-1 levels and PCOS. This suggests a potential role of nesfatin-1 in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings.
Type of Study: Review Article |
Subject:
Reproductive Endocrinology
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