Volume 10, Issue 6 (4-2012)                   IJRM 2012, 10(6): 561-566 | Back to browse issues page

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Khadem N, Rahmani M E, Sanaei A, Afiat M. Association between preterm and low-birth weight with periodontal disease: a case-control study. IJRM 2012; 10 (6) :561-566
URL: http://ijrm.ir/article-1-326-en.html
1- Women's Health Research Center, Department of Obstetrics and Gynecology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Periodontology, Mashhad University of Medical Sciences, Mashhad, Iran
3- Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , sanaeifa911@mums.ac.ir
Abstract:   (2420 Views)
Background: Since preterm delivery is an important problem in obstetrics, it is necessary to know the risk factors. Periodontal disease is an infectious disease and infection is risk factor for preterm delivery. Respecting to the mechanisms of preterm delivery and because involved mediators in this procedure are synthesized in periodontal disease, gum disease is investigated as risk factor for preterm delivery.
Objective: The aim of this study was to determine the association between preterm, low birth weight with periodontal diseases to improve the mothers’ and the children’s health.
Materials and Methods: This cases-control study was done on 70 women (mean age 25.01 yrs.) 35 women with preterm delivery, gestational age <37 weeks and birth weight <2500 gr as case group and 35 women with term delivery, gestational age >37 weeks and birth weight >2500 gr as control group referring to Imam Reza Hospital. Mean Probing Depth (MPD), percent of sites with more than 3 mm in probing, bleeding Index (BI), Plaque Index (PI), and Extent and Severity Index (Ext. and Sev.) were measured using a mirror and a standard William's periodontal probe.
Results: Significant difference was found in Mean Probing Deep (MPD), percentage of sites with more than 3 mm in probing, BI, PI, Ext. and Sev. indices in case and control groups. There was no significant difference in patient’s job, age, education, and husband’s job and education. No difference was observed between two groups in monthly income and gravidity.
Conclusion: Gum disease can be a risk factor for preterm delivery.
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Type of Study: Original Article |

References
1. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. Williams Obstetrics. 22nd Ed. New York: Mcgraw-Hill; 2005: 761-767.
2. Matijasevich A, Cesar JA, Santos IS, Barros AJ, Dode MA, Barros FC, et al. Hospitalizations during infancy in three population-based studies in Southern Brazil: trends and differentials. Cad Saude Publica 2008; 24 (Suppl.): 437-443. [DOI:10.1590/S0102-311X2008001500009]
3. Rocha JM, Chaves VR, Urbanetz AA, Baldissera Rdos S, Rösing CK. Obstetricians' knowledge of periodontal disease as a potential risk factor for preterm delivery and low birth weight. Braz Oral Res 2011; 25: 248-254. [DOI:10.1590/S1806-83242011000300010]
4. McCormick MC. The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 1985; 312: 82-90. [DOI:10.1056/NEJM198501103120204]
5. McGregor JA, French JI, Lawellin D, Todd JK. Preterm birth and infection: pathogenic possibilities. Am J Report Immunol Microbiol. 1988; 16: 123-132. [DOI:10.1111/j.1600-0897.1988.tb00181.x]
6. Galloway CE. Focal infection. Am J Surg 1931; 14: 643-645. [DOI:10.1016/S0002-9610(31)91140-9]
7. Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, et al. Periodontal infection as a possible risk factor for pre-term low birth weight. J periodontal 1996; 67: 1103-1113. [DOI:10.1902/jop.1996.67.10s.1103]
8. Radnai M, Gorzo I. Periodontal disease as a potential risk factor for preterm birth and low birth weight. Fogorv Sz 2002; 95: 241-244.
9. Jarjoura K, Devine PC, Perez-Delboy A, Herrera-Abreu M, D'Alton M, Papapanou PN. Markers of periodontal infection and preterm birth. Am J Obstet Gynecol 2005; 192: 513-519. [DOI:10.1016/j.ajog.2004.07.018]
10. Dannan A. The periodontal disease as a Risk Factor for preterm Birth and Low Birth weight: A Review of case control studies. The Internet Journal of Gynecology and Obstetrics 2008; 10: 5.
11. Carta G, Persia G, Falciglia K, Iovenitti P. Periodontal disease and poor obstetrical outcome. Clin Exp Obstet Gynecol 2004; 31: 47-49.
12. Tarannum F, Faizuddin M. Effect of periodontal therapy on pregnancy outcome in women affected by periodontitis. J Periodontol 2007; 78: 2095-2103. [DOI:10.1902/jop.2007.060388]
13. Crowther CA, Thomas N, Middleton P, Chua M, Esposito M. Treating periodontal disease for preventing preterm birth in pregnant women. (protocol) [Electronid version]. Cochrane Database of systematic Reviews 2005; 2: 1-8.
14. Dörtbudak O, Eberhardt R, Ulm M, Persson GR. Periodontitis, a marker of risk in pregnancy of preterm birth. J Clin Periodontol 2005; 32: 45-52. [DOI:10.1111/j.1600-051X.2004.00630.x]
15. Polyzos NP, Polyzos IP, Zavos A, Valachis A, Mauri D, Papanikolaou EG, et al. Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta-analysis. BMJ 2010; 341: c7017. [DOI:10.1136/bmj.c7017]
16. 1Mannem S, Chava VK. The relationship between maternal periodontitis and preterm low birth weight: A case-control study. Contemp Clin Dent 2011; 2: 88-93. [DOI:10.4103/0976-237X.83067]
17. Africa CW, Kayitenkore J, Bayingana C. Examination of maternal gingival crevicular fluid for the presence of selected periodontopathogens implicated in the pre-term delivery of low birthweight infants. Virulence 2010; 1: 254-259. [DOI:10.4161/viru.1.4.12004]
18. Calabrese N, Calabrese A, Nibali L, Rosati A, Fiengo S, Di Renzo GC. Is there any association between periodontitis and preterm low birth weight? J Matern Fetal Neonatal Med 2010; 23: 1288-1293. [DOI:10.3109/14767051003615467]
19. Goepfert AR, Jeffcoat MK, Andrews WW, Faye-Petersen O, Cliver SP, Goldenberg RL, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 2004; 104: 777-783. [DOI:10.1097/01.AOG.0000139836.47777.6d]
20. Moore S, Ide M, Coward PY, Randhawa M, Borkowska E, Baylis R, et al. A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome. Br Dent J 2004; 197: 251-258. [DOI:10.1038/sj.bdj.4811620]
21. Lunardelli AN, Peres MA. Is there an association between periodontal disease, prematurity and low birth weight? A population-based study. J clin Periodontol 2005; 32: 938-946. [DOI:10.1111/j.1600-051X.2005.00759.x]

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